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Page 1
Did you mean bastian opitz or o itz b schumann (88 results)?
ETB receptor deficiency amplifies allergic airway inflammation and hyperresponsiveness.
Tabeling C, González Calera CR, Gutbier B, Michalick L, Hocher CF, Ahrens K, Naujoks J, Herbert J, Savic LJ, Felten M, Opitz B, Schütte H, Kuebler WM, Tschernig T, Hocher B, Witzenrath M. Tabeling C, et al. Among authors: opitz b. ERJ Open Res. 2026 Jan 26;12(1):00489-2025. doi: 10.1183/23120541.00489-2025. eCollection 2026 Jan. ERJ Open Res. 2026. PMID: 41601581 Free PMC article.
Community-acquired pneumonia in diabetic patients is characterised by a distinct pathogen spectrum and enhanced inflammation: results from CAPNETZ, a prospective observational cohort study.
Millet Pascual-Leone B, Fiocca Vernengo F, Hillus D, Wernicke C, Krishnamoorthy G, Rupp J, Rohde G, Pletz MW, Witzenrath M; CAPNETZ-study group; Suttorp N, Sander LE, Vestergaard Jensen A, Opitz B, Thibeault C. Millet Pascual-Leone B, et al. Among authors: opitz b. Infection. 2026 Feb;54(1):275-285. doi: 10.1007/s15010-025-02659-w. Epub 2025 Oct 12. Infection. 2026. PMID: 41077620 Free PMC article.
Operating and Biocontainment Procedures of a Facility for Laboratory Mice with a Natural Microbiome: Immunophenotyping Procedure.
Drude N, Diederich K, Duerr CU, Haase N, Harms C, Heppner F, Jendrach M, Kahnau P, Kolesnichenko M, Lewejohann L, Kurreck C, Lohan A, Mall MA, Müller D, Nagel-Riedasch S, Opitz B, Schaupp L, Schönfelder G, Weber A, Willimsky G, Zang Y, Rosshart SP, Diefenbach A, Jordan S. Drude N, et al. Among authors: opitz b. J Vis Exp. 2024 Dec 13;(214). doi: 10.3791/67100. J Vis Exp. 2024. PMID: 39760355
Diabetes impairs IFNγ-dependent antibacterial defense in the lungs.
Fiocca Vernengo F, Röwekamp I, Boillot L, Caesar S, Dörner PJ, Tarnowski B, Gutbier B, Nouailles G, Fatykhova D, Hellwig K, Witzenrath M, Hocke AC, Klatt AB, Opitz B. Fiocca Vernengo F, et al. Among authors: opitz b. Mucosal Immunol. 2025 Apr;18(2):431-440. doi: 10.1016/j.mucimm.2024.12.015. Epub 2024 Dec 31. Mucosal Immunol. 2025. PMID: 39746547 Free article.
Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in COVID-19.
Essex M, Millet Pascual-Leone B, Löber U, Kuhring M, Zhang B, Brüning U, Fritsche-Guenther R, Krzanowski M, Fiocca Vernengo F, Brumhard S, Röwekamp I, Anna Bielecka A, Lesker TR, Wyler E, Landthaler M, Mantei A, Meisel C, Caesar S, Thibeault C, Corman VM, Marko L, Suttorp N, Strowig T, Kurth F, Sander LE, Li Y, Kirwan JA, Forslund SK, Opitz B. Essex M, et al. Among authors: opitz b. NPJ Biofilms Microbiomes. 2024 Aug 1;10(1):66. doi: 10.1038/s41522-024-00538-0. NPJ Biofilms Microbiomes. 2024. PMID: 39085233 Free PMC article.
IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota.
Röwekamp I, Maschirow L, Rabes A, Fiocca Vernengo F, Hamann L, Heinz GA, Mashreghi MF, Caesar S, Milek M, Fagundes Fonseca AC, Wienhold SM, Nouailles G, Yao L, Mousavi S, Bruder D, Boehme JD, Puzianowska-Kuznicka M, Beule D, Witzenrath M; CAPNETZ Study Group; Löhning M, Klose CSN, Heimesaat MM, Diefenbach A, Opitz B. Röwekamp I, et al. Among authors: opitz b. Proc Natl Acad Sci U S A. 2024 May 28;121(22):e2310864121. doi: 10.1073/pnas.2310864121. Epub 2024 May 23. Proc Natl Acad Sci U S A. 2024. PMID: 38781213 Free PMC article.
Clinically used broad-spectrum antibiotics compromise inflammatory monocyte-dependent antibacterial defense in the lung.
Dörner PJ, Anandakumar H, Röwekamp I, Fiocca Vernengo F, Millet Pascual-Leone B, Krzanowski M, Sellmaier J, Brüning U, Fritsche-Guenther R, Pfannkuch L, Kurth F, Milek M, Igbokwe V, Löber U, Gutbier B, Holstein M, Heinz GA, Mashreghi MF, Schulte LN, Klatt AB, Caesar S, Wienhold SM, Offermanns S, Mack M, Witzenrath M, Jordan S, Beule D, Kirwan JA, Forslund SK, Wilck N, Bartolomaeus H, Heimesaat MM, Opitz B. Dörner PJ, et al. Among authors: opitz b. Nat Commun. 2024 Mar 30;15(1):2788. doi: 10.1038/s41467-024-47149-z. Nat Commun. 2024. PMID: 38555356 Free PMC article.
Hepatobiliary long-term consequences of COVID-19: dramatically increased rate of secondary sclerosing cholangitis in critically ill COVID-19 patients.
Leonhardt S, Jürgensen C, Frohme J, Grajecki D, Adler A, Sigal M, Leonhardt J, Voll JM, Kruse JM, Körner R, Eckardt KU, Janssen HJ, Gebhardt V, Schmittner MD; Pa-COVID-19 collaborative study group; Frey C, Müller-Ide H, Bauer M, Thibeault C, Kurth F, Sander LE, Müller T, Tacke F. Leonhardt S, et al. Hepatol Int. 2023 Dec;17(6):1610-1625. doi: 10.1007/s12072-023-10521-0. Epub 2023 Apr 29. Hepatol Int. 2023. PMID: 37119516 Free PMC article.
Endothelin B Receptor Immunodynamics in Pulmonary Arterial Hypertension.
Tabeling C, González Calera CR, Lienau J, Höppner J, Tschernig T, Kershaw O, Gutbier B, Naujoks J, Herbert J, Opitz B, Gruber AD, Hocher B, Suttorp N, Heidecke H, Burmester GR, Riemekasten G, Siegert E, Kuebler WM, Witzenrath M. Tabeling C, et al. Among authors: opitz b. Front Immunol. 2022 Jun 9;13:895501. doi: 10.3389/fimmu.2022.895501. eCollection 2022. Front Immunol. 2022. PMID: 35757687 Free PMC article.
Characterization of antimicrobial use and co-infections among hospitalized patients with COVID-19: a prospective observational cohort study.
Lingscheid T, Lippert LJ, Hillus D, Kruis T, Thibeault C, Helbig ET, Tober-Lau P, Pfäfflin F, Müller-Redetzky H, Witzenrath M, Zoller T, Uhrig A, Opitz B, Suttorp N, Kramer TS, Sander LE, Stegemann MS, Kurth F. Lingscheid T, et al. Among authors: opitz b. Infection. 2022 Dec;50(6):1441-1452. doi: 10.1007/s15010-022-01796-w. Epub 2022 Apr 14. Infection. 2022. PMID: 35420370 Free PMC article.
Impact of dexamethasone on SARS-CoV-2 concentration kinetics and antibody response in hospitalized COVID-19 patients: results from a prospective observational study.
Mühlemann B, Thibeault C, Hillus D, Helbig ET, Lippert LJ, Tober-Lau P, Schwarz T, Müller MA; Pa-COVID-19 collaborative study group; Witzenrath M, Suttorp N, Sander LE, Drosten C, Jones TC, Corman VM, Kurth F. Mühlemann B, et al. Clin Microbiol Infect. 2021 Oct;27(10):1520.e7-1520.e10. doi: 10.1016/j.cmi.2021.06.008. Epub 2021 Jun 15. Clin Microbiol Infect. 2021. PMID: 34139335 Free PMC article.
A time-resolved proteomic and prognostic map of COVID-19.
Demichev V, Tober-Lau P, Lemke O, Nazarenko T, Thibeault C, Whitwell H, Röhl A, Freiwald A, Szyrwiel L, Ludwig D, Correia-Melo C, Aulakh SK, Helbig ET, Stubbemann P, Lippert LJ, Grüning NM, Blyuss O, Vernardis S, White M, Messner CB, Joannidis M, Sonnweber T, Klein SJ, Pizzini A, Wohlfarter Y, Sahanic S, Hilbe R, Schaefer B, Wagner S, Mittermaier M, Machleidt F, Garcia C, Ruwwe-Glösenkamp C, Lingscheid T, Bosquillon de Jarcy L, Stegemann MS, Pfeiffer M, Jürgens L, Denker S, Zickler D, Enghard P, Zelezniak A, Campbell A, Hayward C, Porteous DJ, Marioni RE, Uhrig A, Müller-Redetzky H, Zoller H, Löffler-Ragg J, Keller MA, Tancevski I, Timms JF, Zaikin A, Hippenstiel S, Ramharter M, Witzenrath M, Suttorp N, Lilley K, Mülleder M, Sander LE; PA-COVID-19 Study group; Ralser M, Kurth F. Demichev V, et al. Cell Syst. 2021 Aug 18;12(8):780-794.e7. doi: 10.1016/j.cels.2021.05.005. Epub 2021 Jun 14. Cell Syst. 2021. PMID: 34139154 Free PMC article.
Clinical and virological characteristics of hospitalised COVID-19 patients in a German tertiary care centre during the first wave of the SARS-CoV-2 pandemic: a prospective observational study.
Thibeault C, Mühlemann B, Helbig ET, Mittermaier M, Lingscheid T, Tober-Lau P, Meyer-Arndt LA, Meiners L, Stubbemann P, Haenel SS, Bosquillon de Jarcy L, Lippert L, Pfeiffer M, Stegemann MS, Roehle R, Wiebach J, Hippenstiel S, Zoller T, Müller-Redetzky H, Uhrig A, Balzer F, von Kalle C, Suttorp N, Jones TC, Drosten C, Witzenrath M, Sander LE; Pa-COVID Study Group; Corman VM, Kurth F. Thibeault C, et al. Infection. 2021 Aug;49(4):703-714. doi: 10.1007/s15010-021-01594-w. Epub 2021 Apr 22. Infection. 2021. PMID: 33890243 Free PMC article.
Studying the pathophysiology of coronavirus disease 2019: a protocol for the Berlin prospective COVID-19 patient cohort (Pa-COVID-19).
Kurth F, Roennefarth M, Thibeault C, Corman VM, Müller-Redetzky H, Mittermaier M, Ruwwe-Glösenkamp C, Heim KM, Krannich A, Zvorc S, Schmidt S, Kretzler L, Dang-Heine C, Rose M, Hummel M, Hocke A, Hübner RH, Opitz B, Mall MA, Röhmel J, Landmesser U, Pieske B, Knauss S, Endres M, Spranger J, Mockenhaupt FP, Tacke F, Treskatsch S, Angermair S, Siegmund B, Spies C, Weber-Carstens S, Eckardt KU, Schürmann D, Uhrig A, Stegemann MS, Zoller T, Drosten C, Suttorp N, Witzenrath M, Hippenstiel S, von Kalle C, Sander LE. Kurth F, et al. Among authors: opitz b. Infection. 2020 Aug;48(4):619-626. doi: 10.1007/s15010-020-01464-x. Epub 2020 Jun 13. Infection. 2020. PMID: 32535877 Free PMC article.
Antibiotic treatment-induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia.
Robak OH, Heimesaat MM, Kruglov AA, Prepens S, Ninnemann J, Gutbier B, Reppe K, Hochrein H, Suter M, Kirschning CJ, Marathe V, Buer J, Hornef MW, Schnare M, Schneider P, Witzenrath M, Bereswill S, Steinhoff U, Suttorp N, Sander LE, Chaput C, Opitz B. Robak OH, et al. Among authors: opitz b. J Clin Invest. 2018 Aug 1;128(8):3535-3545. doi: 10.1172/JCI97065. Epub 2018 Jul 16. J Clin Invest. 2018. PMID: 29771684 Free PMC article.
Recognition of microbial viability via TLR8 drives TFH cell differentiation and vaccine responses.
Ugolini M, Gerhard J, Burkert S, Jensen KJ, Georg P, Ebner F, Volkers SM, Thada S, Dietert K, Bauer L, Schäfer A, Helbig ET, Opitz B, Kurth F, Sur S, Dittrich N, Gaddam S, Conrad ML, Benn CS, Blohm U, Gruber AD, Hutloff A, Hartmann S, Boekschoten MV, Müller M, Jungersen G, Schumann RR, Suttorp N, Sander LE. Ugolini M, et al. Among authors: opitz b. Nat Immunol. 2018 Apr;19(4):386-396. doi: 10.1038/s41590-018-0068-4. Epub 2018 Mar 19. Nat Immunol. 2018. PMID: 29556002
The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans.
Ruiz-Moreno JS, Hamann L, Shah JA, Verbon A, Mockenhaupt FP, Puzianowska-Kuznicka M, Naujoks J, Sander LE, Witzenrath M, Cambier JC, Suttorp N, Schumann RR, Jin L, Hawn TR, Opitz B; CAPNETZ Study Group. Ruiz-Moreno JS, et al. Among authors: opitz b. PLoS Pathog. 2018 Jan 3;14(1):e1006829. doi: 10.1371/journal.ppat.1006829. eCollection 2018 Jan. PLoS Pathog. 2018. PMID: 29298342 Free PMC article. Clinical Trial.
Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia.
Dietert K, Gutbier B, Wienhold SM, Reppe K, Jiang X, Yao L, Chaput C, Naujoks J, Brack M, Kupke A, Peteranderl C, Becker S, von Lachner C, Baal N, Slevogt H, Hocke AC, Witzenrath M, Opitz B, Herold S, Hackstein H, Sander LE, Suttorp N, Gruber AD. Dietert K, et al. Among authors: opitz b. PLoS One. 2017 Nov 20;12(11):e0188251. doi: 10.1371/journal.pone.0188251. eCollection 2017. PLoS One. 2017. PMID: 29155867 Free PMC article.
Correction: The Common R71H-G230A-R293Q Human TMEM173 Is a Null Allele.
Patel S, Blaauboer SM, Tucker HR, Mansouri S, Ruiz-Moreno JS, Hamann L, Schumann RR, Opitz B, Jin L. Patel S, et al. Among authors: opitz b. J Immunol. 2017 Jun 1;198(11):4547. doi: 10.4049/jimmunol.1700477. J Immunol. 2017. PMID: 28533283 No abstract available.
The Common R71H-G230A-R293Q Human TMEM173 Is a Null Allele.
Patel S, Blaauboer SM, Tucker HR, Mansouri S, Ruiz-Moreno JS, Hamann L, Schumann RR, Opitz B, Jin L. Patel S, et al. Among authors: opitz b. J Immunol. 2017 Jan 15;198(2):776-787. doi: 10.4049/jimmunol.1601585. Epub 2016 Dec 7. J Immunol. 2017. PMID: 27927967 Free PMC article.
IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid.
Naujoks J, Tabeling C, Dill BD, Hoffmann C, Brown AS, Kunze M, Kempa S, Peter A, Mollenkopf HJ, Dorhoi A, Kershaw O, Gruber AD, Sander LE, Witzenrath M, Herold S, Nerlich A, Hocke AC, van Driel I, Suttorp N, Bedoui S, Hilbi H, Trost M, Opitz B. Naujoks J, et al. Among authors: opitz b. PLoS Pathog. 2016 Feb 1;12(2):e1005408. doi: 10.1371/journal.ppat.1005408. eCollection 2016 Feb. PLoS Pathog. 2016. PMID: 26829557 Free PMC article.
Serotype 1 and 8 Pneumococci Evade Sensing by Inflammasomes in Human Lung Tissue.
Fatykhova D, Rabes A, Machnik C, Guruprasad K, Pache F, Berg J, Toennies M, Bauer TT, Schneider P, Schimek M, Eggeling S, Mitchell TJ, Mitchell AM, Hilker R, Hain T, Suttorp N, Hippenstiel S, Hocke AC, Opitz B. Fatykhova D, et al. Among authors: opitz b. PLoS One. 2015 Aug 28;10(8):e0137108. doi: 10.1371/journal.pone.0137108. eCollection 2015. PLoS One. 2015. PMID: 26317436 Free PMC article.
NOD-Like Receptors in Lung Diseases.
Chaput C, Sander LE, Suttorp N, Opitz B. Chaput C, et al. Among authors: opitz b. Front Immunol. 2013 Nov 21;4:393. doi: 10.3389/fimmu.2013.00393. Front Immunol. 2013. PMID: 24312100 Free PMC article. Review.
Streptococcus pneumoniae stimulates a STING- and IFN regulatory factor 3-dependent type I IFN production in macrophages, which regulates RANTES production in macrophages, cocultured alveolar epithelial cells, and mouse lungs.
Koppe U, Högner K, Doehn JM, Müller HC, Witzenrath M, Gutbier B, Bauer S, Pribyl T, Hammerschmidt S, Lohmeyer J, Suttorp N, Herold S, Opitz B. Koppe U, et al. Among authors: opitz b. J Immunol. 2012 Jan 15;188(2):811-7. doi: 10.4049/jimmunol.1004143. Epub 2011 Dec 12. J Immunol. 2012. PMID: 22156592
The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia.
Witzenrath M, Pache F, Lorenz D, Koppe U, Gutbier B, Tabeling C, Reppe K, Meixenberger K, Dorhoi A, Ma J, Holmes A, Trendelenburg G, Heimesaat MM, Bereswill S, van der Linden M, Tschopp J, Mitchell TJ, Suttorp N, Opitz B. Witzenrath M, et al. Among authors: opitz b. J Immunol. 2011 Jul 1;187(1):434-40. doi: 10.4049/jimmunol.1003143. Epub 2011 Jun 6. J Immunol. 2011. PMID: 21646297
Legionella pneumophila induces human beta defensin-3 in pulmonary cells.
Scharf S, Vardarova K, Lang F, Schmeck B, Opitz B, Flieger A, Heuner K, Hippenstiel S, Suttorp N, N'Guessan PD. Scharf S, et al. Among authors: opitz b. Respir Res. 2010 Jul 8;11(1):93. doi: 10.1186/1465-9921-11-93. Respir Res. 2010. PMID: 20615218 Free PMC article.
Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages.
Netea MG, Nold-Petry CA, Nold MF, Joosten LA, Opitz B, van der Meer JH, van de Veerdonk FL, Ferwerda G, Heinhuis B, Devesa I, Funk CJ, Mason RJ, Kullberg BJ, Rubartelli A, van der Meer JW, Dinarello CA. Netea MG, et al. Among authors: opitz b. Blood. 2009 Mar 5;113(10):2324-35. doi: 10.1182/blood-2008-03-146720. Epub 2008 Dec 22. Blood. 2009. PMID: 19104081 Free PMC article.
NAIP and Ipaf control Legionella pneumophila replication in human cells.
Vinzing M, Eitel J, Lippmann J, Hocke AC, Zahlten J, Slevogt H, N'guessan PD, Günther S, Schmeck B, Hippenstiel S, Flieger A, Suttorp N, Opitz B. Vinzing M, et al. Among authors: opitz b. J Immunol. 2008 May 15;180(10):6808-15. doi: 10.4049/jimmunol.180.10.6808. J Immunol. 2008. PMID: 18453601
Moraxella catarrhalis is internalized in respiratory epithelial cells by a trigger-like mechanism and initiates a TLR2- and partly NOD1-dependent inflammatory immune response.
Slevogt H, Seybold J, Tiwari KN, Hocke AC, Jonatat C, Dietel S, Hippenstiel S, Singer BB, Bachmann S, Suttorp N, Opitz B. Slevogt H, et al. Among authors: opitz b. Cell Microbiol. 2007 Mar;9(3):694-707. doi: 10.1111/j.1462-5822.2006.00821.x. Epub 2006 Oct 18. Cell Microbiol. 2007. PMID: 17054439
Moraxella catarrhalis induces inflammatory response of bronchial epithelial cells via MAPK and NF-kappaB activation and histone deacetylase activity reduction.
Slevogt H, Schmeck B, Jonatat C, Zahlten J, Beermann W, van Laak V, Opitz B, Dietel S, N'Guessan PD, Hippenstiel S, Suttorp N, Seybold J. Slevogt H, et al. Among authors: opitz b. Am J Physiol Lung Cell Mol Physiol. 2006 May;290(5):L818-26. doi: 10.1152/ajplung.00428.2005. Epub 2006 Jan 6. Am J Physiol Lung Cell Mol Physiol. 2006. PMID: 16399788 Free article.
Pneumococci induced TLR- and Rac1-dependent NF-kappaB-recruitment to the IL-8 promoter in lung epithelial cells.
Schmeck B, Huber S, Moog K, Zahlten J, Hocke AC, Opitz B, Hammerschmidt S, Mitchell TJ, Kracht M, Rosseau S, Suttorp N, Hippenstiel S. Schmeck B, et al. Among authors: opitz b. Am J Physiol Lung Cell Mol Physiol. 2006 Apr;290(4):L730-L737. doi: 10.1152/ajplung.00271.2005. Epub 2005 Nov 18. Am J Physiol Lung Cell Mol Physiol. 2006. PMID: 16299055 Free article.