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722 results
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Chemokine expression in IBD. Mucosal chemokine expression is unselectively increased in both ulcerative colitis and Crohn's disease.
Banks C, Bateman A, Payne R, Johnson P, Sheron N. Banks C, et al. J Pathol. 2003 Jan;199(1):28-35. doi: 10.1002/path.1245. J Pathol. 2003. PMID: 12474223
Thirty-nine patients were included, ten controls, 20 ulcerative colitis (UC), and nine Crohn's disease (CD), with a range of disease activity. ...Sections were analysed using a light microscope. Expression of all types of chemokine protein was detected in colonic mu …
Thirty-nine patients were included, ten controls, 20 ulcerative colitis (UC), and nine Crohn's disease (CD), with a range of disease …
Apoptosis and proliferation of acinar and islet cells in chronic pancreatitis: evidence for differential cell loss mediating preservation of islet function.
Bateman AC, Turner SM, Thomas KS, McCrudden PR, Fine DR, Johnson PA, Johnson CD, Iredale JP. Bateman AC, et al. Gut. 2002 Apr;50(4):542-8. doi: 10.1136/gut.50.4.542. Gut. 2002. PMID: 11889077 Free PMC article.
BACKGROUND: Chronic pancreatitis is characterised clinically by early exocrine insufficiency, with diabetes mellitus occurring as a late phenomenon. ...CONCLUSION: Apoptosis plays a significant role in acinar loss in chronic pancreatitis. Acinar Bcl-2 and islet Bax …
BACKGROUND: Chronic pancreatitis is characterised clinically by early exocrine insufficiency, with diabetes mellitus occurring as a l …
Expression of transforming growth factor-beta 1 by pancreatic stellate cells and its implications for matrix secretion and turnover in chronic pancreatitis.
Shek FW, Benyon RC, Walker FM, McCrudden PR, Pender SL, Williams EJ, Johnson PA, Johnson CD, Bateman AC, Fine DR, Iredale JP. Shek FW, et al. Am J Pathol. 2002 May;160(5):1787-98. doi: 10.1016/s0002-9440(10)61125-x. Am J Pathol. 2002. PMID: 12000730 Free PMC article.
Transforming growth factor-beta (TGF-beta) is a key regulator of extracellular matrix production and myofibroblast proliferation. ...
Transforming growth factor-beta (TGF-beta) is a key regulator of extracellular matrix production and myofibroblast proliferation. ...
Breast cancer in patients with germline TP53 pathogenic variants have typical tumour characteristics: the Cohort study of TP53 carrier early onset breast cancer (COPE study).
Packwood K, Martland G, Sommerlad M, Shaw E, Moutasim K, Thomas G, Bateman AC, Jones L, Haywood L, Evans DG, Birch JM, Alsalmi OA, Henderson A, Poplawski N, Eccles DM. Packwood K, et al. J Pathol Clin Res. 2019 Jul;5(3):189-198. doi: 10.1002/cjp2.133. Epub 2019 May 23. J Pathol Clin Res. 2019. PMID: 31041842 Free PMC article.
Germline TP53 pathogenic variants are rare but associated with a high risk of cancer; they are often identified in the context of clinically diagnosed Li-Fraumeni syndrome predisposing to a range of young onset cancers including sarcomas and breast cancer. The study …
Germline TP53 pathogenic variants are rare but associated with a high risk of cancer; they are often identified in the context of cli …
Primary Clear Cell Microcystic Adenoma of the Sinonasal Cavity: Pathological or Fortuitous Association?
Cooper R, Markham H, Theaker J, Bateman A, Bunyan D, Sommerlad M, Crawford G, Eccles D. Cooper R, et al. Case Rep Pathol. 2017;2017:9236780. doi: 10.1155/2017/9236780. Epub 2017 Feb 5. Case Rep Pathol. 2017. PMID: 28261513 Free PMC article.
Imaging demonstrated a mass in the ethmoid sinus. Initial clinical suspicion was of metastatic ccRCC. However, tumour morphology and immunoprofile were distinct from the previous ccRCC and supported a diagnosis of primary microcystic adenoma. ...Although this did no …
Imaging demonstrated a mass in the ethmoid sinus. Initial clinical suspicion was of metastatic ccRCC. However, tumour morphology and …
ROC-king onwards: intraepithelial lymphocyte counts, distribution & role in coeliac disease mucosal interpretation.
Rostami K, Marsh MN, Johnson MW, Mohaghegh H, Heal C, Holmes G, Ensari A, Aldulaimi D, Bancel B, Bassotti G, Bateman A, Becheanu G, Bozzola A, Carroccio A, Catassi C, Ciacci C, Ciobanu A, Danciu M, Derakhshan MH, Elli L, Ferrero S, Fiorentino M, Fiorino M, Ganji A, Ghaffarzadehgan K, Going JJ, Ishaq S, Mandolesi A, Mathews S, Maxim R, Mulder CJ, Neefjes-Borst A, Robert M, Russo I, Rostami-Nejad M, Sidoni A, Sotoudeh M, Villanacci V, Volta U, Zali MR, Srivastava A. Rostami K, et al. Gut. 2017 Dec;66(12):2080-2086. doi: 10.1136/gutjnl-2017-314297. Epub 2017 Sep 11. Gut. 2017. PMID: 28893865 Free PMC article. Clinical Trial.
Additionally, there was a sufficiently high number of biopsies to explore IEL counts across the subclassification of the Marsh III lesion. ...No differences in IEL counts were found between Marsh III a, b and c lesions. There was an indication of a continuous …
Additionally, there was a sufficiently high number of biopsies to explore IEL counts across the subclassification of the Marsh III le …
Increased expression of the 5-lipoxygenase pathway and its cellular localization in Barrett's adenocarcinoma.
Boger PC, Shutt JD, Neale JR, Wilson SJ, Bateman AC, Holloway JW, Patel P, Sampson AP. Boger PC, et al. Histopathology. 2012 Sep;61(3):509-17. doi: 10.1111/j.1365-2559.2012.04258.x. Epub 2012 Jun 13. Histopathology. 2012. PMID: 22690932
Immunohistochemical analyses were performed on stromal and epithelial areas with optimized concentrations of primary antibodies for 5-LOX, 5-LOX-activating protein (FLAP), and the distal enzymes leukotriene (LT) A(4) hydrolase (LTA(4) H) and LTC(4) synthase (LTC(4) S). the …
Immunohistochemical analyses were performed on stromal and epithelial areas with optimized concentrations of primary antibodies for 5-LOX, 5 …
Colonic expression of leukotriene-pathway enzymes in inflammatory bowel diseases.
Jupp J, Hillier K, Elliott DH, Fine DR, Bateman AC, Johnson PA, Cazaly AM, Penrose JF, Sampson AP. Jupp J, et al. Inflamm Bowel Dis. 2007 May;13(5):537-46. doi: 10.1002/ibd.20094. Inflamm Bowel Dis. 2007. PMID: 17230539
BACKGROUND: Leukotrienes derived from the 5-lipoxygenase pathway are proinflammatory lipid mediators that possibly play a role in inflammatory bowel diseases. ...CONCLUSIONS: The 5-lipoxygenase data provide a cellular basis for increased tissue synthesis of the leuk …
BACKGROUND: Leukotrienes derived from the 5-lipoxygenase pathway are proinflammatory lipid mediators that possibly play a role in inf …
DNA mismatch repair enzyme immunohistochemistry in colorectal cancer: a comparison of biopsy and resection material.
Kumarasinghe AP, de Boer B, Bateman AC, Kumarasinghe MP. Kumarasinghe AP, et al. Pathology. 2010;42(5):414-20. doi: 10.3109/00313025.2010.493862. Pathology. 2010. PMID: 20632816
A single observer blindly examined intensity and distribution of staining and assessed MMRP expression. Two consultant histopathologists reviewed challenging cases. ...
A single observer blindly examined intensity and distribution of staining and assessed MMRP expression. Two consultant histopathologi
Prognostic significance of cyclooxygenase-2 (COX-2) expression in patients with surgically resectable adenocarcinoma of the oesophagus.
Bhandari P, Bateman AC, Mehta RL, Stacey BS, Johnson P, Cree IA, Di Nicolantonio F, Patel P. Bhandari P, et al. BMC Cancer. 2006 May 19;6:134. doi: 10.1186/1471-2407-6-134. BMC Cancer. 2006. PMID: 16712734 Free PMC article.
COX-2 protein expression was assessed by immunohistochemistry in all patients and COX-2 m-RNA expression was measured by quantitative RT-PCR in a small group of patients. ...A COX-2 score of >200 was associated with a median survival of 10 months compared …
COX-2 protein expression was assessed by immunohistochemistry in all patients and COX-2 m-RNA expression was measured by quantitative RT-PCR …
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