Bateman RJ - Search Results

1

A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system.

Bateman RJ, Siemers ER, Mawuenyega KG, Wen G, Browning KR, Sigurdson WC, Yarasheski KE, Friedrich SW, Demattos RB, May PC, Paul SM, Holtzman DM. Bateman RJ, et al. Ann Neurol. 2009 Jul;66(1):48-54. doi: 10.1002/ana.21623. Ann Neurol. 2009. PMID: 19360898 Free PMC article. Clinical Trial.

2

Matrix metalloproteinase-9 degrades amyloid-beta fibrils in vitro and compact plaques in situ.

Yan P, Hu X, Song H, Yin K, Bateman RJ, Cirrito JR, Xiao Q, Hsu FF, Turk JW, Xu J, Hsu CY, Holtzman DM, Lee JM. Yan P, et al. Among authors: bateman rj. J Biol Chem. 2006 Aug 25;281(34):24566-74. doi: 10.1074/jbc.M602440200. Epub 2006 Jun 20. J Biol Chem. 2006. PMID: 16787929 Free article.

3

Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo.

Bateman RJ, Munsell LY, Morris JC, Swarm R, Yarasheski KE, Holtzman DM. Bateman RJ, et al. Nat Med. 2006 Jul;12(7):856-61. doi: 10.1038/nm1438. Epub 2006 Jun 25. Nat Med. 2006. PMID: 16799555 Free PMC article.

4

Matrix metalloproteinases expressed by astrocytes mediate extracellular amyloid-beta peptide catabolism.

Yin KJ, Cirrito JR, Yan P, Hu X, Xiao Q, Pan X, Bateman R, Song H, Hsu FF, Turk J, Xu J, Hsu CY, Mills JC, Holtzman DM, Lee JM. Yin KJ, et al. J Neurosci. 2006 Oct 25;26(43):10939-48. doi: 10.1523/JNEUROSCI.2085-06.2006. J Neurosci. 2006. PMID: 17065436 Free PMC article.

5

Fluctuations of CSF amyloid-beta levels: implications for a diagnostic and therapeutic biomarker.

Bateman RJ, Wen G, Morris JC, Holtzman DM. Bateman RJ, et al. Neurology. 2007 Feb 27;68(9):666-9. doi: 10.1212/01.wnl.0000256043.50901.e3. Neurology. 2007. PMID: 17325273

6

Stable isotope labeling tandem mass spectrometry (SILT) to quantify protein production and clearance rates.

Bateman RJ, Munsell LY, Chen X, Holtzman DM, Yarasheski KE. Bateman RJ, et al. J Am Soc Mass Spectrom. 2007 Jun;18(6):997-1006. doi: 10.1016/j.jasms.2007.02.009. Epub 2007 Feb 22. J Am Soc Mass Spectrom. 2007. PMID: 17383190 Free PMC article.

7

Stable isotope labeling tandem mass spectrometry (SILT): integration with peptide identification and extension to data-dependent scans.

Elbert DL, Mawuenyega KG, Scott EA, Wildsmith KR, Bateman RJ. Elbert DL, et al. Among authors: bateman rj. J Proteome Res. 2008 Oct;7(10):4546-56. doi: 10.1021/pr800386u. Epub 2008 Sep 6. J Proteome Res. 2008. PMID: 18774841 Free PMC article.

8

Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle.

Kang JE, Lim MM, Bateman RJ, Lee JJ, Smyth LP, Cirrito JR, Fujiki N, Nishino S, Holtzman DM. Kang JE, et al. Among authors: bateman rj. Science. 2009 Nov 13;326(5955):1005-7. doi: 10.1126/science.1180962. Epub 2009 Sep 24. Science. 2009. PMID: 19779148 Free PMC article.

9

Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound.

Cook JJ, Wildsmith KR, Gilberto DB, Holahan MA, Kinney GG, Mathers PD, Michener MS, Price EA, Shearman MS, Simon AJ, Wang JX, Wu G, Yarasheski KE, Bateman RJ. Cook JJ, et al. Among authors: bateman rj. J Neurosci. 2010 May 12;30(19):6743-50. doi: 10.1523/JNEUROSCI.1381-10.2010. J Neurosci. 2010. PMID: 20463236 Free PMC article.

10

Decreased clearance of CNS beta-amyloid in Alzheimer's disease.

Mawuenyega KG, Sigurdson W, Ovod V, Munsell L, Kasten T, Morris JC, Yarasheski KE, Bateman RJ. Mawuenyega KG, et al. Among authors: bateman rj. Science. 2010 Dec 24;330(6012):1774. doi: 10.1126/science.1197623. Epub 2010 Dec 9. Science. 2010. PMID: 21148344 Free PMC article.

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