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UGA4 gene encoding the gamma-aminobutyric acid permease in Saccharomyces cerevisiae is an acid-expressed gene.
Moretti MB, Batlle A, Garcia SC. Moretti MB, et al. Int J Biochem Cell Biol. 2001 Dec;33(12):1202-7. doi: 10.1016/s1357-2725(01)00085-1. Int J Biochem Cell Biol. 2001. PMID: 11606256
METHODS: we analyzed the effect of pH on the expression of UGA4 gene measuring beta-galactosidase activity in cells carrying a UGA4::lacZ fusion gene. ...Using a strain lacking Uga43p we clearly showed that the effect of ambient pH on UGA4 expression is not a
METHODS: we analyzed the effect of pH on the expression of UGA4 gene measuring beta-galactosidase activity in cells carrying a UGA4:: …
Bilirubin: its role in cytoprotection against oxidative stress.
Tomaro ML, Batlle AM. Tomaro ML, et al. Int J Biochem Cell Biol. 2002 Mar;34(3):216-20. doi: 10.1016/s1357-2725(01)00130-3. Int J Biochem Cell Biol. 2002. PMID: 11849989 Review.
Bilirubin, the end product of heme catabolism in mammals, is generally regarded as a potentially cytotoxic, lipid-soluble waste product that needs to be excreted. ...Therefore, the idea of a beneficial and physiological role for bilirubin in cytoprotection against s …
Bilirubin, the end product of heme catabolism in mammals, is generally regarded as a potentially cytotoxic, lipid-soluble waste produ …
ALA and ALA hexyl ester in free and liposomal formulations for the photosensitisation of tumour organ cultures.
Casas A, Perotti C, Saccoliti M, Sacca P, Fukuda H, Batlle AM. Casas A, et al. Br J Cancer. 2002 Mar 4;86(5):837-42. doi: 10.1038/sj.bjc.6600144. Br J Cancer. 2002. PMID: 11875750 Free PMC article.
In a later stage, cytoplasmic and nuclear disintegration are observed. By electronic microscopy the involvement of the endocytic pathway in the incorporation of liposomal 5-aminolevulinic acid into the cells was shown....
In a later stage, cytoplasmic and nuclear disintegration are observed. By electronic microscopy the involvement of the endocytic path …
Ros production by endogenously generated Protoporphyrin IX in murine leukemia cells.
Diez B, Cordo Russo R, Teijo MJ, Hajos S, Batlle A, Fukuda H. Diez B, et al. Cell Mol Biol (Noisy-le-grand). 2009 Jul 1;55(2):15-9. Cell Mol Biol (Noisy-le-grand). 2009. PMID: 19656446
Photodynamic and light independent action of 8 to 2 carboxylic free porphyrins on some haem-enzymes.
Afonso SG, Enríquez de Salamanca R, Batlle A. Afonso SG, et al. Int J Biochem Cell Biol. 2001 Dec;33(12):1208-14. doi: 10.1016/s1357-2725(01)00084-x. Int J Biochem Cell Biol. 2001. PMID: 11606257
To better understand the relationship between the structure and physicochemical properties of porphyrins and their specific effect on protein configuration, the action of a whole range of 8 to 2 carboxylic porphyrins has been studied. ...
To better understand the relationship between the structure and physicochemical properties of porphyrins and their specific effect on protei …
On the promoting action of tamoxifen in a model of hepatocarcinogenesis induced by p-dimethylaminoazobenzene in CF1 mice.
Caballero F, Gerez E, Oliveri L, Falcoff N, Batlle A, Vazquez E. Caballero F, et al. Int J Biochem Cell Biol. 2001 Jul;33(7):681-90. doi: 10.1016/s1357-2725(01)00056-5. Int J Biochem Cell Biol. 2001. PMID: 11390276
TMX has been demonstrated to be an initiator and/or a promoter in the rat model of hepatocarcinogenesis. To document the long-term effect of TMX in mice treated with p-dimethylaminoazobenzene (DAB), we have investigated the time response action of these drugs on different …
TMX has been demonstrated to be an initiator and/or a promoter in the rat model of hepatocarcinogenesis. To document the long-term ef …
Delta-aminolevulinic acid transport through blood-brain barrier.
García SC, Moretti MB, Garay MV, Batlle A. García SC, et al. Gen Pharmacol. 1998 Oct;31(4):579-82. doi: 10.1016/s0306-3623(98)00038-x. Gen Pharmacol. 1998. PMID: 9792218
GABA transport (Km=3.2+/-0.1 microM and Vmax=0.299+/-0.045 micromol/mg protein min) is probably mediated by a permease similar to Saccharomyces cerevisiae PUT4; this result also indicates that the isolated capillaries are metabolically active. 3. ...
GABA transport (Km=3.2+/-0.1 microM and Vmax=0.299+/-0.045 micromol/mg protein min) is probably mediated by a permease similar to Sac …
Sequence and structure of the rat housekeeping PBG-D isoform.
Cardalda CA, Batlle A, Juknat AA. Cardalda CA, et al. Biochem Biophys Res Commun. 1998 Aug 19;249(2):438-43. doi: 10.1006/bbrc.1998.9021. Biochem Biophys Res Commun. 1998. PMID: 9712715
Porphobilinogen deaminase (PBG-D), a key enzyme in the tetrapyrrole biosynthetic pathway, is encoded by a single gene containing two different promoters. ...The cDNA encodes a 39,361 Da protein composed of 361 amino acids. Nucleotide sequence comparison betwe …
Porphobilinogen deaminase (PBG-D), a key enzyme in the tetrapyrrole biosynthetic pathway, is encoded by a single gene containi …
Rat harderian gland porphobilinogen deaminase: characterization studies and regulatory action of protoporphyrin IX.
Cardalda CA, Juknat AA, Princ FG, Batlle A. Cardalda CA, et al. Arch Biochem Biophys. 1997 Nov 1;347(1):69-77. doi: 10.1006/abbi.1997.0310. Arch Biochem Biophys. 1997. PMID: 9344466
The enzyme behaves as a monomer of Mr 38 +/- 2 kDa and is optimally active at pH 8.0-8.2. Its activation energy, determined by an Arrhenius plot, is 76.1 kJ/mol. Initial velocity studies showed a linear progress curve for uroporphyringen I formation and a hyp …
The enzyme behaves as a monomer of Mr 38 +/- 2 kDa and is optimally active at pH 8.0-8.2. Its activation energy, determined by an Arr …
Cell cycle arrest and modulation of HO-1 expression induced by acetyl salicylic acid in hepatocarcinogenesis.
Sacca P, Caballero F, Batlle A, Vazquez E. Sacca P, et al. Int J Biochem Cell Biol. 2004 Oct;36(10):1945-53. doi: 10.1016/j.biocel.2004.01.029. Int J Biochem Cell Biol. 2004. PMID: 15203109
We investigated the hepatic expression of cyclin D1, cyclin E, Cdk2, Cdk4, p21, p27, p53; the level of bcl-2, an antiapoptotic protein and of heme oxygenase-1 (HO-1), a marker of oxidative stress, by Western blot analysis. ...
We investigated the hepatic expression of cyclin D1, cyclin E, Cdk2, Cdk4, p21, p27, p53; the level of bcl-2, an antiapoptotic protein and o …
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