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Interferon regulatory factors in hematopoietic cell differentiation and immune regulation.
Battistini A. Battistini A. J Interferon Cytokine Res. 2009 Dec;29(12):765-80. doi: 10.1089/jir.2009.0030. J Interferon Cytokine Res. 2009. PMID: 19929577 Review.
Members of the interferon regulatory factor (IRF) family are transcription factors implicated in the regulation of a variety of biological processes. ...In this review the role of some members of the family more deeply involved in the differentiation of hematopoietic cells …
Members of the interferon regulatory factor (IRF) family are transcription factors implicated in the regulation of a variety of biolo …
A model of the three-dimensional structure of human interferon responsive factor 1 and its modifications upon phosphorylation or phosphorylation-mimicking mutations.
Storchi L, Remoli AL, Marsili G, Acchioni C, Acchioni M, Battistini A, Sgarbanti M, Marrone A. Storchi L, et al. J Biomol Struct Dyn. 2019 Oct;37(17):4632-4643. doi: 10.1080/07391102.2018.1557558. Epub 2019 Jan 19. J Biomol Struct Dyn. 2019. PMID: 30569833
In particular, a 5'-SXXXSXS-3' motif of the protein represents the target of the IκB-related kinases, TANK-binding kinase (TBK)-1 and inhibitor of nuclear factor kappa-B kinase (IKK)-ε. Here, a 3D model of human IRF-1 was determined by using multi-template comparati …
In particular, a 5'-SXXXSXS-3' motif of the protein represents the target of the IκB-related kinases, TANK-binding kinase (TBK)-1 and …
Interferon fundamentals: a tribute to the scientific vision of G B Rossi. Editorial.
Battistini A, Coccia EM, Belardelli F. Battistini A, et al. Cytokine Growth Factor Rev. 2015 Apr;26(2):95-7. doi: 10.1016/j.cytogfr.2014.12.003. Epub 2014 Dec 26. Cytokine Growth Factor Rev. 2015. PMID: 25578521 No abstract available.
HIV-1 Tat Recruits HDM2 E3 Ligase To Target IRF-1 for Ubiquitination and Proteasomal Degradation.
Remoli AL, Marsili G, Perrotti E, Acchioni C, Sgarbanti M, Borsetti A, Hiscott J, Battistini A. Remoli AL, et al. mBio. 2016 Oct 18;7(5):e01528-16. doi: 10.1128/mBio.01528-16. mBio. 2016. PMID: 27795392 Free PMC article.
Nevertheless, HIV-1 infection remains a challenge, and the identification of useful cellular targets for therapeutic intervention remains a major goal. ...Restoration of IRF-1 functionality may thus be regarded as a potential strategy to reinstate both a
Nevertheless, HIV-1 infection remains a challenge, and the identification of useful cellular targets for therapeutic intervention rem …
Interferon regulatory factor-1 acts as a powerful adjuvant in tat DNA based vaccination.
Castaldello A, Sgarbanti M, Marsili G, Brocca-Cofano E, Remoli AL, Caputo A, Battistini A. Castaldello A, et al. J Cell Physiol. 2010 Sep;224(3):702-9. doi: 10.1002/jcp.22169. J Cell Physiol. 2010. PMID: 20432465
There is, therefore, a pressing need for adjuvants capable of enhancing the immunogenicity and effectiveness of these vaccines. ...Balb/c mice were immunized by three intramuscular inoculations, using a DNA prime-protein boost protocol, with a DNA encoding ta …
There is, therefore, a pressing need for adjuvants capable of enhancing the immunogenicity and effectiveness of these vaccines. ...Ba …
Human papillomavirus type 16 E5 protein induces expression of beta interferon through interferon regulatory factor 1 in human keratinocytes.
Muto V, Stellacci E, Lamberti AG, Perrotti E, Carrabba A, Matera G, Sgarbanti M, Battistini A, Liberto MC, Focà A. Muto V, et al. J Virol. 2011 May;85(10):5070-80. doi: 10.1128/JVI.02114-10. Epub 2011 Mar 9. J Virol. 2011. PMID: 21389130 Free PMC article.
Our data show a new and unexpected role for HR-HPV E5 protein and indicate that HPV16 E5 may contribute to the mechanisms responsible for cervical carcinogenesis in part via stimulation of IFN-β and an IFN signature, with IRF-1 playing a pivotal role. ...
Our data show a new and unexpected role for HR-HPV E5 protein and indicate that HPV16 E5 may contribute to the mechanisms responsible …
Critical role of IRF-8 in negative regulation of TLR3 expression by Src homology 2 domain-containing protein tyrosine phosphatase-2 activity in human myeloid dendritic cells.
Fragale A, Stellacci E, Ilari R, Remoli AL, Lanciotti A, Perrotti E, Shytaj I, Orsatti R, Lawrence HR, Lawrence NJ, Wu J, Rehli M, Ozato K, Battistini A. Fragale A, et al. J Immunol. 2011 Feb 15;186(4):1951-62. doi: 10.4049/jimmunol.1000918. Epub 2011 Jan 10. J Immunol. 2011. PMID: 21220691 Free PMC article.
TLR3 plays a crucial role in the recognition of viral pathogens and induction of immune responses by myeloid DCs. IFN regulatory factor (IRF)-8, a member of the IRF family, is a transcriptional regulator that plays essential roles in the development and funct …
TLR3 plays a crucial role in the recognition of viral pathogens and induction of immune responses by myeloid DCs. IFN regulatory fact …
Analysis of the signal transduction pathway leading to human immunodeficiency virus-1-induced interferon regulatory factor-1 upregulation.
Sgarbanti M, Marsili G, Remoli AL, Ridolfi B, Stellacci E, Borsetti A, Ensoli B, Battistini A. Sgarbanti M, et al. Ann N Y Acad Sci. 2004 Dec;1030:187-95. doi: 10.1196/annals.1329.024. Ann N Y Acad Sci. 2004. PMID: 15659797
Interferon (IFN) regulatory factors (IRFs) constitute a family of transcriptional activators and repressors involved in the regulation of immune system, host defense, and cell growth. ...Moreover, a significant decrease in HIV-1 replication was observed upon de novo …
Interferon (IFN) regulatory factors (IRFs) constitute a family of transcriptional activators and repressors involved in the regulatio …
IRF-1 is required for full NF-kappaB transcriptional activity at the human immunodeficiency virus type 1 long terminal repeat enhancer.
Sgarbanti M, Remoli AL, Marsili G, Ridolfi B, Borsetti A, Perrotti E, Orsatti R, Ilari R, Sernicola L, Stellacci E, Ensoli B, Battistini A. Sgarbanti M, et al. J Virol. 2008 Apr;82(7):3632-41. doi: 10.1128/JVI.00599-07. Epub 2008 Jan 23. J Virol. 2008. PMID: 18216101 Free PMC article.
Human immunodeficiency virus type 1 (HIV-1) gene expression is controlled by a complex interplay between viral and host factors. ...We provide evidence that IRF-1 and NF-kappaB form a functional complex at the long terminal repeat (LTR) kappaB sites, which is abolis …
Human immunodeficiency virus type 1 (HIV-1) gene expression is controlled by a complex interplay between viral and host factors. ...W …
IRF-8 controls melanoma progression by regulating the cross talk between cancer and immune cells within the tumor microenvironment.
Mattei F, Schiavoni G, Sestili P, Spadaro F, Fragale A, Sistigu A, Lucarini V, Spada M, Sanchez M, Scala S, Battistini A, Belardelli F, Gabriele L. Mattei F, et al. Neoplasia. 2012 Dec;14(12):1223-35. doi: 10.1593/neo.121444. Neoplasia. 2012. PMID: 23308054 Free PMC article.
The transcription factor interferon regulatory factor-8 (IRF-8) is crucial for myeloid cell development and immune response and also acts as a tumor suppressor gene. ...Noticeably, primary tumors developing in IRF-8(-/-) mice displayed a clear-cut inhibition of IRF- …
The transcription factor interferon regulatory factor-8 (IRF-8) is crucial for myeloid cell development and immune response and also acts as …
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