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Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death.
Garcia-Bermudez J, Baudrier L, Bayraktar EC, Shen Y, La K, Guarecuco R, Yucel B, Fiore D, Tavora B, Freinkman E, Chan SH, Lewis C, Min W, Inghirami G, Sabatini DM, Birsoy K. Garcia-Bermudez J, et al. Among authors: baudrier l. Nature. 2019 Mar;567(7746):118-122. doi: 10.1038/s41586-019-0945-5. Epub 2019 Feb 13. Nature. 2019. PMID: 30760928 Free PMC article.
Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours.
Garcia-Bermudez J, Baudrier L, La K, Zhu XG, Fidelin J, Sviderskiy VO, Papagiannakopoulos T, Molina H, Snuderl M, Lewis CA, Possemato RL, Birsoy K. Garcia-Bermudez J, et al. Among authors: baudrier l. Nat Cell Biol. 2018 Jul;20(7):775-781. doi: 10.1038/s41556-018-0118-z. Epub 2018 Jun 25. Nat Cell Biol. 2018. PMID: 29941933 Free PMC article.
ZBTB1 Regulates Asparagine Synthesis and Leukemia Cell Response to L-Asparaginase.
Williams RT, Guarecuco R, Gates LA, Barrows D, Passarelli MC, Carey B, Baudrier L, Jeewajee S, La K, Prizer B, Malik S, Garcia-Bermudez J, Zhu XG, Cantor J, Molina H, Carroll T, Roeder RG, Abdel-Wahab O, Allis CD, Birsoy K. Williams RT, et al. Among authors: baudrier l. Cell Metab. 2020 Apr 7;31(4):852-861.e6. doi: 10.1016/j.cmet.2020.03.008. Cell Metab. 2020. PMID: 32268116 Free PMC article.
Adaptive stimulation of macropinocytosis overcomes aspartate limitation in cancer cells under hypoxia.
Garcia-Bermudez J, Badgley MA, Prasad S, Baudrier L, Liu Y, La K, Soula M, Williams RT, Yamaguchi N, Hwang RF, Taylor LJ, de Stanchina E, Rostandy B, Alwaseem H, Molina H, Bar-Sagi D, Birsoy K. Garcia-Bermudez J, et al. Among authors: baudrier l. Nat Metab. 2022 Jun;4(6):724-738. doi: 10.1038/s42255-022-00583-z. Epub 2022 Jun 20. Nat Metab. 2022. PMID: 35726024 Free PMC article.
Dietary thiamine influences l-asparaginase sensitivity in a subset of leukemia cells.
Guarecuco R, Williams RT, Baudrier L, La K, Passarelli MC, Ekizoglu N, Mestanoglu M, Alwaseem H, Rostandy B, Fidelin J, Garcia-Bermudez J, Molina H, Birsoy K. Guarecuco R, et al. Among authors: baudrier l. Sci Adv. 2020 Oct 9;6(41):eabc7120. doi: 10.1126/sciadv.abc7120. Print 2020 Oct. Sci Adv. 2020. PMID: 33036978 Free PMC article.
Functional Genomics In Vivo Reveal Metabolic Dependencies of Pancreatic Cancer Cells.
Zhu XG, Chudnovskiy A, Baudrier L, Prizer B, Liu Y, Ostendorf BN, Yamaguchi N, Arab A, Tavora B, Timson R, Heissel S, de Stanchina E, Molina H, Victora GD, Goodarzi H, Birsoy K. Zhu XG, et al. Among authors: baudrier l. Cell Metab. 2021 Jan 5;33(1):211-221.e6. doi: 10.1016/j.cmet.2020.10.017. Epub 2020 Nov 4. Cell Metab. 2021. PMID: 33152324 Free PMC article.
CRISPR-based genome editing through the lens of DNA repair.
Nambiar TS, Baudrier L, Billon P, Ciccia A. Nambiar TS, et al. Among authors: baudrier l. Mol Cell. 2022 Jan 20;82(2):348-388. doi: 10.1016/j.molcel.2021.12.026. Mol Cell. 2022. PMID: 35063100 Free PMC article. Review.
11 results