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Recent Progress in Lyme Disease and Remaining Challenges.
Bobe JR, Jutras BL, Horn EJ, Embers ME, Bailey A, Moritz RL, Zhang Y, Soloski MJ, Ostfeld RS, Marconi RT, Aucott J, Ma'ayan A, Keesing F, Lewis K, Ben Mamoun C, Rebman AW, McClune ME, Breitschwerdt EB, Reddy PJ, Maggi R, Yang F, Nemser B, Ozcan A, Garner O, Di Carlo D, Ballard Z, Joung HA, Garcia-Romeu A, Griffiths RR, Baumgarth N, Fallon BA. Bobe JR, et al. Front Med (Lausanne). 2021 Aug 18;8:666554. doi: 10.3389/fmed.2021.666554. eCollection 2021. Front Med (Lausanne). 2021. PMID: 34485323 Free PMC article. Review.
Antigen-Specific CD4 T Cell and B Cell Responses to Borrelia burgdorferi.
Hammond EM, Olsen KJ, Ram S, Tran GVV, Hall LS, Bradley JE, Lund FE, Samuels DS, Baumgarth N. Hammond EM, et al. J Immunol. 2023 Sep 15;211(6):994-1005. doi: 10.4049/jimmunol.2200890. J Immunol. 2023. PMID: 37556156
Long-lived T-dependent B cell responses fail to develop during persistent infection of mice with Borrelia burgdorferi, the causative agent of Lyme disease, raising questions about the induction and/or functionality of anti-B. burgdorferi adaptive immune responses. ...Flow …
Long-lived T-dependent B cell responses fail to develop during persistent infection of mice with Borrelia burgdorferi, the causative …
Borrelia burgdorferi Manipulates Innate and Adaptive Immunity to Establish Persistence in Rodent Reservoir Hosts.
Tracy KE, Baumgarth N. Tracy KE, et al. Front Immunol. 2017 Feb 20;8:116. doi: 10.3389/fimmu.2017.00116. eCollection 2017. Front Immunol. 2017. PMID: 28265270 Free PMC article. Review.
Borrelia burgdorferi sensu lato species complex is capable of establishing persistent infections in a wide variety of species, particularly rodents. ...
Borrelia burgdorferi sensu lato species complex is capable of establishing persistent infections in a wide variety of species, partic
CD4 T cell responses in persistent Borrelia burgdorferi infection.
Hammond EM, Baumgarth N. Hammond EM, et al. Curr Opin Immunol. 2022 Aug;77:102187. doi: 10.1016/j.coi.2022.102187. Epub 2022 May 9. Curr Opin Immunol. 2022. PMID: 35550259 Review.
Infection of mice with Borrelia burgdorferi (Bb), a tick-transmitted spirochete and the pathogen that causes Lyme disease in humans, triggers CD4 T cell activation in secondary lymphoid tissues, from which they disseminate into various infected tissues. ...
Infection of mice with Borrelia burgdorferi (Bb), a tick-transmitted spirochete and the pathogen that causes Lyme disease in humans, …
Immune Response to Borrelia: Lessons from Lyme Disease Spirochetes.
Bockenstedt LK, Wooten RM, Baumgarth N. Bockenstedt LK, et al. Curr Issues Mol Biol. 2021;42:145-190. doi: 10.21775/cimb.042.145. Epub 2020 Dec 8. Curr Issues Mol Biol. 2021. PMID: 33289684 Free PMC article.
The mammalian host responds to infection with Borrelia spirochetes through a highly orchestrated immune defense involving innate and adaptive effector functions aimed toward limiting pathogen burdens, minimizing tissue injury, and preventing subsequent reinfection. The evo …
The mammalian host responds to infection with Borrelia spirochetes through a highly orchestrated immune defense involving innate and …
Report of the Pathogenesis and Pathophysiology of Lyme Disease Subcommittee of the HHS Tick Borne Disease Working Group.
Donta ST, States LJ, Adams WA, Bankhead T, Baumgarth N, Embers ME, Lochhead RB, Stevenson B. Donta ST, et al. Front Med (Lausanne). 2021 Jun 7;8:643235. doi: 10.3389/fmed.2021.643235. eCollection 2021. Front Med (Lausanne). 2021. PMID: 34164410 Free PMC article. Review.
To better understand the various mechanisms underlying the infection caused by Borrelia burgdorferi, the Pathogenesis and Pathophysiology of Lyme Disease Subcommittee was formed to review what is currently known about the pathogenesis and pathophysiology of Lyme disease, f …
To better understand the various mechanisms underlying the infection caused by Borrelia burgdorferi, the Pathogenesis and Pathophysio …
Delays and diversions mark the development of B cell responses to Borrelia burgdorferi infection.
Hastey CJ, Elsner RA, Barthold SW, Baumgarth N. Hastey CJ, et al. J Immunol. 2012 Jun 1;188(11):5612-22. doi: 10.4049/jimmunol.1103735. Epub 2012 Apr 30. J Immunol. 2012. PMID: 22547698 Free PMC article.
B cell responses modulate disease during infection with Borrelia burgdorferi, the causative agent of Lyme disease, but are unable to clear the infection. ...
B cell responses modulate disease during infection with Borrelia burgdorferi, the causative agent of Lyme disease, but are unable to …
Suppression of Long-Lived Humoral Immunity Following Borrelia burgdorferi Infection.
Elsner RA, Hastey CJ, Olsen KJ, Baumgarth N. Elsner RA, et al. PLoS Pathog. 2015 Jul 2;11(7):e1004976. doi: 10.1371/journal.ppat.1004976. eCollection 2015 Jul. PLoS Pathog. 2015. PMID: 26136236 Free PMC article.
Lyme Disease caused by infection with Borrelia burgdorferi is an emerging infectious disease and already by far the most common vector-borne disease in the U.S. ...We show here that B. burgdorferi infected mice show a similar rapid disappearance of Borrelia-specific …
Lyme Disease caused by infection with Borrelia burgdorferi is an emerging infectious disease and already by far the most common vecto …
Borrelia burgdorferi Infection-Induced Persistent IgM Secretion Controls Bacteremia, but Not Bacterial Dissemination or Tissue Burden.
Hastey CJ, Olsen KJ, Elsner RA, Mundigl S, Tran GVV, Barthold SW, Baumgarth N. Hastey CJ, et al. J Immunol. 2023 Nov 15;211(10):1540-1549. doi: 10.4049/jimmunol.2300384. J Immunol. 2023. PMID: 37782044
Infection with Borrelia burgdorferi causes Lyme disease in humans. In small rodents, the natural reservoir species of this spirochete, infections lead to only modest disease manifestations, despite causing persistence infection. ...Although IgM was passively protective and …
Infection with Borrelia burgdorferi causes Lyme disease in humans. In small rodents, the natural reservoir species of this spirochete …
MyD88- and TRIF-independent induction of type I interferon drives naive B cell accumulation but not loss of lymph node architecture in Lyme disease.
Hastey CJ, Ochoa J, Olsen KJ, Barthold SW, Baumgarth N. Hastey CJ, et al. Infect Immun. 2014 Apr;82(4):1548-58. doi: 10.1128/IAI.00969-13. Epub 2014 Jan 22. Infect Immun. 2014. PMID: 24452685 Free PMC article.
Rapidly after infection, live Borrelia burgdorferi, the causative agent of Lyme disease, is found within lymph nodes, causing rapid and strong tissue enlargement, a loss of demarcation between B cell follicles and T cell zones, and an unusually large accumulation of B cell …
Rapidly after infection, live Borrelia burgdorferi, the causative agent of Lyme disease, is found within lymph nodes, causing rapid a …
12 results