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Perspective of cyclin-dependent kinase 9 (CDK9) as a drug target.
Krystof V, Baumli S, F├╝rst R. Krystof V, et al. Among authors: baumli s. Curr Pharm Des. 2012;18(20):2883-90. doi: 10.2174/138161212800672750. Curr Pharm Des. 2012. PMID: 22571657 Free PMC article. Review.
Herpes Simplex Virus 1 (HSV-1) ICP22 protein directly interacts with cyclin-dependent kinase (CDK)9 to inhibit RNA polymerase II transcription elongation.
Zaborowska J, Baumli S, Laitem C, O'Reilly D, Thomas PH, O'Hare P, Murphy S. Zaborowska J, et al. Among authors: baumli s. PLoS One. 2014 Sep 18;9(9):e107654. doi: 10.1371/journal.pone.0107654. eCollection 2014. PLoS One. 2014. PMID: 25233083 Free PMC article.
Substituted 4-(thiazol-5-yl)-2-(phenylamino)pyrimidines are highly active CDK9 inhibitors: synthesis, X-ray crystal structures, structure-activity relationship, and anticancer activities.
Shao H, Shi S, Huang S, Hole AJ, Abbas AY, Baumli S, Liu X, Lam F, Foley DW, Fischer PM, Noble M, Endicott JA, Pepper C, Wang S. Shao H, et al. Among authors: baumli s. J Med Chem. 2013 Feb 14;56(3):640-59. doi: 10.1021/jm301475f. Epub 2013 Jan 25. J Med Chem. 2013. PMID: 23301767 Free PMC article.
Comparative structural and functional studies of 4-(thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 inhibitors suggest the basis for isotype selectivity.
Hole AJ, Baumli S, Shao H, Shi S, Huang S, Pepper C, Fischer PM, Wang S, Endicott JA, Noble ME. Hole AJ, et al. Among authors: baumli s. J Med Chem. 2013 Feb 14;56(3):660-70. doi: 10.1021/jm301495v. Epub 2013 Jan 29. J Med Chem. 2013. PMID: 23252711 Free PMC article.
The CDK9 tail determines the reaction pathway of positive transcription elongation factor b.
Baumli S, Hole AJ, Wang LZ, Noble ME, Endicott JA. Baumli S, et al. Structure. 2012 Oct 10;20(10):1788-95. doi: 10.1016/j.str.2012.08.011. Epub 2012 Sep 6. Structure. 2012. PMID: 22959624 Free PMC article.
Halogen bonds form the basis for selective P-TEFb inhibition by DRB.
Baumli S, Endicott JA, Johnson LN. Baumli S, et al. Chem Biol. 2010 Sep 24;17(9):931-6. doi: 10.1016/j.chembiol.2010.07.012. Chem Biol. 2010. PMID: 20851342
The CDK9 C-helix exhibits conformational plasticity that may explain the selectivity of CAN508.
Baumli S, Hole AJ, Noble ME, Endicott JA. Baumli S, et al. ACS Chem Biol. 2012 May 18;7(5):811-6. doi: 10.1021/cb2004516. Epub 2012 Feb 10. ACS Chem Biol. 2012. PMID: 22292676 Free PMC article.
The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation.
Baumli S, Lolli G, Lowe ED, Troiani S, Rusconi L, Bullock AN, Debreczeni JE, Knapp S, Johnson LN. Baumli S, et al. EMBO J. 2008 Jul 9;27(13):1907-18. doi: 10.1038/emboj.2008.121. Epub 2008 Jun 19. EMBO J. 2008. PMID: 18566585 Free PMC article.
The binding of flavopiridol to blood serum albumin.
Myatt D, Johnson L, Baumli S, Siligardi G. Myatt D, et al. Among authors: baumli s. Chirality. 2010;22 Suppl 1:E40-3. doi: 10.1002/chir.20925. Chirality. 2010. PMID: 21038395
Structure of the mediator subunit cyclin C and its implications for CDK8 function.
Hoeppner S, Baumli S, Cramer P. Hoeppner S, et al. Among authors: baumli s. J Mol Biol. 2005 Jul 29;350(5):833-42. doi: 10.1016/j.jmb.2005.05.041. J Mol Biol. 2005. PMID: 15979093
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