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Tolerance, not immunity, crucially depends on IL-2.
Malek TR, Bayer AL. Malek TR, et al. Nat Rev Immunol. 2004 Sep;4(9):665-74. doi: 10.1038/nri1435. Nat Rev Immunol. 2004. PMID: 15343366 Review.
Adoptive T Regulatory Cell Therapy for Tolerance Induction.
Cabello-Kindelan C, Mackey S, Bayer AL. Cabello-Kindelan C, et al. Curr Transplant Rep. 2015 Jun 1;2(2):191-201. doi: 10.1007/s40472-015-0058-5. Curr Transplant Rep. 2015. PMID: 25938011 Free PMC article.
Expansion of a restricted residual host T reg-cell repertoire is dependent on IL-2 following experimental autologous hematopoietic stem transplantation.
Bayer AL, Chirinos J, Cabello C, Yang J, Matsutani T, Malek TR, Levy RB. Bayer AL, et al. Eur J Immunol. 2011 Dec;41(12):3467-78. doi: 10.1002/eji.201141611. Epub 2011 Oct 31. Eur J Immunol. 2011. PMID: 21928285 Free PMC article.
Altered homeostasis and development of regulatory T cell subsets represent an IL-2R-dependent risk for diabetes in NOD mice.
Dwyer CJ, Bayer AL, Fotino C, Yu L, Cabello-Kindelan C, Ward NC, Toomer KH, Chen Z, Malek TR. Dwyer CJ, et al. Among authors: bayer al. Sci Signal. 2017 Dec 19;10(510):eaam9563. doi: 10.1126/scisignal.aam9563. Sci Signal. 2017. PMID: 29259102 Free PMC article.
The Expanding Role of Natural Killer Cells in Type 1 Diabetes and Immunotherapy.
Fraker C, Bayer AL. Fraker C, et al. Among authors: bayer al. Curr Diab Rep. 2016 Nov;16(11):109. doi: 10.1007/s11892-016-0806-7. Curr Diab Rep. 2016. PMID: 27664042 Review.
Host CD4+CD25+ T cells can expand and comprise a major component of the Treg compartment after experimental HCT.
Bayer AL, Jones M, Chirinos J, de Armas L, Schreiber TH, Malek TR, Levy RB. Bayer AL, et al. Blood. 2009 Jan 15;113(3):733-43. doi: 10.1182/blood-2008-08-173179. Epub 2008 Oct 2. Blood. 2009. PMID: 18832651 Free PMC article.
IL-2 family of cytokines in T regulatory cell development and homeostasis.
Malek TR, Yu A, Zhu L, Matsutani T, Adeegbe D, Bayer AL. Malek TR, et al. J Clin Immunol. 2008 Nov;28(6):635-9. doi: 10.1007/s10875-008-9235-y. Epub 2008 Aug 26. J Clin Immunol. 2008. PMID: 18726679
A function for IL-7R for CD4+CD25+Foxp3+ T regulatory cells.
Bayer AL, Lee JY, de la Barrera A, Surh CD, Malek TR. Bayer AL, et al. J Immunol. 2008 Jul 1;181(1):225-34. doi: 10.4049/jimmunol.181.1.225. J Immunol. 2008. PMID: 18566388 Free PMC article.
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