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Page 1
Effect of construct design on MAPKAP kinase-2 activity, thermodynamic stability and ligand-binding affinity.
Kervinen J, Ma H, Bayoumy S, Schubert C, Milligan C, Lewandowski F, Moriarty K, Desjarlais RL, Ramachandren K, Wang H, Harris CA, Grasberger B, Todd M, Springer BA, Deckman I. Kervinen J, et al. Among authors: bayoumy s. Arch Biochem Biophys. 2006 May 15;449(1-2):47-56. doi: 10.1016/j.abb.2006.03.018. Epub 2006 Mar 31. Arch Biochem Biophys. 2006. PMID: 16620770
Structural basis for elastolytic substrate specificity in rodent alpha-chymases.
Kervinen J, Abad M, Crysler C, Kolpak M, Mahan AD, Masucci JA, Bayoumy S, Cummings MD, Yao X, Olson M, de Garavilla L, Kuo L, Deckman I, Spurlino J. Kervinen J, et al. Among authors: bayoumy s. J Biol Chem. 2008 Jan 4;283(1):427-436. doi: 10.1074/jbc.M707157200. Epub 2007 Oct 31. J Biol Chem. 2008. PMID: 17981788 Free article.
Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation.
Scannevin RH, Alexander R, Haarlander TM, Burke SL, Singer M, Huo C, Zhang YM, Maguire D, Spurlino J, Deckman I, Carroll KI, Lewandowski F, Devine E, Dzordzorme K, Tounge B, Milligan C, Bayoumy S, Williams R, Schalk-Hihi C, Leonard K, Jackson P, Todd M, Kuo LC, Rhodes KJ. Scannevin RH, et al. Among authors: bayoumy s. J Biol Chem. 2017 Oct 27;292(43):17963-17974. doi: 10.1074/jbc.M117.806075. Epub 2017 Aug 31. J Biol Chem. 2017. PMID: 28860188 Free PMC article.
Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 Å resolution.
Schalk-Hihi C, Schubert C, Alexander R, Bayoumy S, Clemente JC, Deckman I, DesJarlais RL, Dzordzorme KC, Flores CM, Grasberger B, Kranz JK, Lewandowski F, Liu L, Ma H, Maguire D, Macielag MJ, McDonnell ME, Mezzasalma Haarlander T, Miller R, Milligan C, Reynolds C, Kuo LC. Schalk-Hihi C, et al. Among authors: bayoumy s. Protein Sci. 2011 Apr;20(4):670-83. doi: 10.1002/pro.596. Epub 2011 Mar 1. Protein Sci. 2011. PMID: 21308848 Free PMC article.
Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors.
Qiao L, Baumann CA, Crysler CS, Ninan NS, Abad MC, Spurlino JC, Desjarlais RL, Kervinen J, Neeper MP, Bayoumy SS, Williams R, Deckman IC, Dasgupta M, Reed RL, Huebert ND, Tomczuk BE, Moriarty KJ. Qiao L, et al. Among authors: bayoumy ss. Bioorg Med Chem Lett. 2006 Jan 1;16(1):123-8. doi: 10.1016/j.bmcl.2005.09.037. Epub 2005 Oct 19. Bioorg Med Chem Lett. 2006. PMID: 16236500
A novel fluorogenic substrate for the measurement of endothelial lipase activity.
Darrow AL, Olson MW, Xin H, Burke SL, Smith C, Schalk-Hihi C, Williams R, Bayoumy SS, Deckman IC, Todd MJ, Damiano BP, Connelly MA. Darrow AL, et al. Among authors: bayoumy ss. J Lipid Res. 2011 Feb;52(2):374-82. doi: 10.1194/jlr.D007971. J Lipid Res. 2011. PMID: 21062953 Free PMC article.
The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2.
Qi J, Lang W, Geisler JG, Wang P, Petrounia I, Mai S, Smith C, Askari H, Struble GT, Williams R, Bhanot S, Monia BP, Bayoumy S, Grant E, Caldwell GW, Todd MJ, Liang Y, Gaul MD, Demarest KT, Connelly MA. Qi J, et al. Among authors: bayoumy s. J Lipid Res. 2012 Jun;53(6):1106-16. doi: 10.1194/jlr.M020156. Epub 2012 Apr 3. J Lipid Res. 2012. PMID: 22493088 Free PMC article.
Potency variation of small-molecule chymase inhibitors across species.
Kervinen J, Crysler C, Bayoumy S, Abad MC, Spurlino J, Deckman I, Greco MN, Maryanoff BE, de Garavilla L. Kervinen J, et al. Among authors: bayoumy s. Biochem Pharmacol. 2010 Oct 1;80(7):1033-41. doi: 10.1016/j.bcp.2010.06.014. Epub 2010 Jun 23. Biochem Pharmacol. 2010. PMID: 20599788
BAD enables ceramide to signal apoptosis via Ras and Raf-1.
Basu S, Bayoumy S, Zhang Y, Lozano J, Kolesnick R. Basu S, et al. Among authors: bayoumy s. J Biol Chem. 1998 Nov 13;273(46):30419-26. doi: 10.1074/jbc.273.46.30419. J Biol Chem. 1998. PMID: 9804808 Free article.
In COS-7 cells, ceramide signals Raf-1 activation through Ras (Zhang, Y., Yao, B., Delikat, S., Bayoumy, S., Lin, X. H., Basu, S., McGinley, M., Chan-Hui, P. ...
In COS-7 cells, ceramide signals Raf-1 activation through Ras (Zhang, Y., Yao, B., Delikat, S., Bayoumy, S., Lin, X. H. …
29 results