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PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer.
Milella M, Falcone I, Conciatori F, Matteoni S, Sacconi A, De Luca T, Bazzichetto C, Corbo V, Simbolo M, Sperduti I, Benfante A, Del Curatolo A, Cesta Incani U, Malusa F, Eramo A, Sette G, Scarpa A, Konopleva M, Andreeff M, McCubrey JA, Blandino G, Todaro M, Stassi G, De Maria R, Cognetti F, Del Bufalo D, Ciuffreda L. Milella M, et al. Among authors: bazzichetto c. Sci Rep. 2017 Feb 21;7:43013. doi: 10.1038/srep43013. Sci Rep. 2017. PMID: 28220839 Free PMC article.
mTOR Cross-Talk in Cancer and Potential for Combination Therapy.
Conciatori F, Ciuffreda L, Bazzichetto C, Falcone I, Pilotto S, Bria E, Cognetti F, Milella M. Conciatori F, et al. Among authors: bazzichetto c. Cancers (Basel). 2018 Jan 19;10(1):23. doi: 10.3390/cancers10010023. Cancers (Basel). 2018. PMID: 29351204 Free PMC article. Review.
Therapeutic potential of combined BRAF/MEK blockade in BRAF-wild type preclinical tumor models.
Del Curatolo A, Conciatori F, Cesta Incani U, Bazzichetto C, Falcone I, Corbo V, D'Agosto S, Eramo A, Sette G, Sperduti I, De Luca T, Marabese M, Shirasawa S, De Maria R, Scarpa A, Broggini M, Del Bufalo D, Cognetti F, Milella M, Ciuffreda L. Del Curatolo A, et al. Among authors: bazzichetto c. J Exp Clin Cancer Res. 2018 Jul 9;37(1):140. doi: 10.1186/s13046-018-0820-5. J Exp Clin Cancer Res. 2018. PMID: 29986755 Free PMC article.
Role of mTOR Signaling in Tumor Microenvironment: An Overview.
Conciatori F, Bazzichetto C, Falcone I, Pilotto S, Bria E, Cognetti F, Milella M, Ciuffreda L. Conciatori F, et al. Among authors: bazzichetto c. Int J Mol Sci. 2018 Aug 19;19(8):2453. doi: 10.3390/ijms19082453. Int J Mol Sci. 2018. PMID: 30126252 Free PMC article. Review.
22 results