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How a Single 5 eV Electron Can Induce Double-Strand Breaks in DNA: A Time-Dependent Density Functional Theory Study.
Kumar A, Sevilla MD, Sanche L. Kumar A, et al. J Phys Chem B. 2024 Apr 23. doi: 10.1021/acs.jpcb.3c08367. Online ahead of print. J Phys Chem B. 2024. PMID: 38652830
The energy profile of each excited state and the corresponding PES are obtained by simultaneously stretching both C5'-O5' bonds of ds[5'-G-3']. From the nature of the PES, we find two dissociative (sigma*) states localized on the PO(4) groups at the C5' sites of ds[ …
The energy profile of each excited state and the corresponding PES are obtained by simultaneously stretching both C5'-O5' bonds of ds …
Dynamic Cervical Spinal Canal Stenosis: Identifying Imaging Risk Factors in Extended Positions.
Matsumoto S, Aoyama R, Yamane J, Ninomiya K, Takahashi Y, Kitamura K, Nori S, Suzuki S, Anazawa U, Shiraishi T. Matsumoto S, et al. Asian Spine J. 2024 Apr 23. doi: 10.31616/asj.2023.0262. Online ahead of print. Asian Spine J. 2024. PMID: 38650094
RESULTS: During extension, new stenosis frequently appeared caudal to the stenosis site in a neutral position, particularly at C5/C6 and C6/C7. A low SAC was identified as a significant risk factor for the development of new stenosis in both the upper and lower adjacent di …
RESULTS: During extension, new stenosis frequently appeared caudal to the stenosis site in a neutral position, particularly at C5/C6 …
Derivatization of 2,1,3-Benzothiadiazole via Regioselective C-H Functionalization and Aryne Reactivity.
Kunz S, Barnå F, Urrutia MP, Ingner FJL, Martínez-Topete A, Orthaber A, Gates PJ, Pilarski LT, Dyrager C. Kunz S, et al. J Org Chem. 2024 Apr 22. doi: 10.1021/acs.joc.4c00122. Online ahead of print. J Org Chem. 2024. PMID: 38648018
We show that regioselective Ir-catalyzed C-H borylation allows access to versatile 5-boryl or 4,6-diboryl BTD building blocks, which undergo functionalization at the C4, C5, C6, and C7 positions. The optimization and regioselectivity of C-H borylation are discussed. ...
We show that regioselective Ir-catalyzed C-H borylation allows access to versatile 5-boryl or 4,6-diboryl BTD building blocks, which undergo …
Sequential treatment of concomitant odontoid fracture and lower cervical fracture-dislocation: A case report.
Zhu Y, Qian J, Hu H, Zhou F, Yang H, Shi J. Zhu Y, et al. Int J Surg Case Rep. 2024 Apr 20;118:109636. doi: 10.1016/j.ijscr.2024.109636. Online ahead of print. Int J Surg Case Rep. 2024. PMID: 38643655
At the 4 months follow-up, a CT scan demonstrated solid bone fusion at C5-6, C6-7 segments, along with successful healing at the odontoid fracture site. However, spinal cord was necrosis at C5-7 segments, and the patient's neurological function had no improvement. . …
At the 4 months follow-up, a CT scan demonstrated solid bone fusion at C5-6, C6-7 segments, along with successful healing at the odon …
Deciphering proteomic mechanisms explaining the role of glutathione as an aid in improving plant fitness and tolerance against cadmium-toxicity in Brassica napus L.
Mittra PK, Rahman MA, Roy SK, Kwon SJ, Yun SH, Kun C, Zhou M, Katsube-Tanaka T, Shiraiwa T, Woo SH. Mittra PK, et al. J Hazard Mater. 2024 Apr 9;471:134262. doi: 10.1016/j.jhazmat.2024.134262. Online ahead of print. J Hazard Mater. 2024. PMID: 38640678
Interestingly, several key proteins including glutathione S-transferase F9 (A0A078GBY1), ATP sulfurylase 2 (A0A078GW82), cystine lyase CORI3 (A0A078FC13), ferredoxin-dependent glutamate synthase 1 (A0A078HXC0), glutaredoxin-C5 (A0A078ILU9), glutaredoxin-C2 (A0A078HHH4) act …
Interestingly, several key proteins including glutathione S-transferase F9 (A0A078GBY1), ATP sulfurylase 2 (A0A078GW82), cystine lyase CORI3 …
Expanding the adenovirus toolbox: reporter viruses for studying the dynamics of human adenovirus replication.
King CR, Dodge MJ, MacNeil KM, Tessier TM, Mymryk JS, Mehle A. King CR, et al. J Virol. 2024 Apr 19:e0020724. doi: 10.1128/jvi.00207-24. Online ahead of print. J Virol. 2024. PMID: 38639487
To streamline standard virological assays, we developed a suite of nine fluorescent or bioluminescent replication competent human species C5 adenovirus reporter viruses that mimic their parental wild-type counterpart. ...This suite of replication competent reporter viruses …
To streamline standard virological assays, we developed a suite of nine fluorescent or bioluminescent replication competent human species …
Monoclonal antibody therapies for aquaporin-4-immunoglobulin G-positive neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein antibody-associated disease.
Tisavipat N, Juan HY, Chen JJ. Tisavipat N, et al. Saudi J Ophthalmol. 2023 Oct 24;38(1):2-12. doi: 10.4103/sjopt.sjopt_102_23. eCollection 2024 Jan-Mar. Saudi J Ophthalmol. 2023. PMID: 38628414 Free PMC article.
In 2019, several randomized, placebo-controlled trials were completed that demonstrated the remarkable efficacy of eculizumab (anti-C5 complement inhibitor), inebilizumab (anti-CD19 B-cell-depleting agent), and satralizumab (anti-interleukin-6 receptor), leading to the Foo …
In 2019, several randomized, placebo-controlled trials were completed that demonstrated the remarkable efficacy of eculizumab (anti-C5 …
Eculizumab in myasthenia gravis: A review.
Zhou A, Ho S, Vickers A. Zhou A, et al. Saudi J Ophthalmol. 2024 Jan 6;38(1):34-40. doi: 10.4103/sjopt.sjopt_74_23. eCollection 2024 Jan-Mar. Saudi J Ophthalmol. 2024. PMID: 38628404 Free PMC article.
Eculizumab, a monoclonal antibody against complement C5, is a novel therapy to treat refractory myasthenia gravis (MG). ...
Eculizumab, a monoclonal antibody against complement C5, is a novel therapy to treat refractory myasthenia gravis (MG). ...
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