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A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.
Serrano M, Hannon GJ, Beach D. Serrano M, et al. Nature. 1993 Dec 16;366(6456):704-7. doi: 10.1038/366704a0. Nature. 1993. PMID: 8259215
CDK4 exists, in part, as a multi-protein complex with a D-type cyclin, proliferating cell nuclear antigen and a protein, p21 (refs 7-9). ...Here we report the isolation of a human p16 complementary DNA and demonstrate that p16 binds to CDK4 and inhibits the catalytic activ …
CDK4 exists, in part, as a multi-protein complex with a D-type cyclin, proliferating cell nuclear antigen and a protein, p21 (refs 7- …
Polycomb CBX7 has a unifying role in cellular lifespan.
Gil J, Bernard D, Martínez D, Beach D. Gil J, et al. Nat Cell Biol. 2004 Jan;6(1):67-72. doi: 10.1038/ncb1077. Epub 2003 Nov 30. Nat Cell Biol. 2004. PMID: 14647293
Human HTm4 is a hematopoietic cell cycle regulator.
Donato JL, Ko J, Kutok JL, Cheng T, Shirakawa T, Mao XQ, Beach D, Scadden DT, Sayegh MH, Adra CN. Donato JL, et al. J Clin Invest. 2002 Jan;109(1):51-8. doi: 10.1172/JCI14025. J Clin Invest. 2002. PMID: 11781350 Free PMC article.
Targeting CDK4 and CDK6: From Discovery to Therapy.
Sherr CJ, Beach D, Shapiro GI. Sherr CJ, et al. Cancer Discov. 2016 Apr;6(4):353-67. doi: 10.1158/2159-8290.CD-15-0894. Epub 2015 Dec 11. Cancer Discov. 2016. PMID: 26658964 Free PMC article. Review.
Biochemical and genetic characterization of D-type cyclins, their cyclin D-dependent kinases (CDK4 and CDK6), and the polypeptide CDK4/6 inhibitor p16(INK4)over two decades ago revealed how mammalian cells regulate entry into the DNA synthetic (S) phase of the cell- …
Biochemical and genetic characterization of D-type cyclins, their cyclin D-dependent kinases (CDK4 and CDK6), and the polypept …
Role of the chromobox protein CBX7 in lymphomagenesis.
Scott CL, Gil J, Hernando E, Teruya-Feldstein J, Narita M, Martínez D, Visakorpi T, Mu D, Cordon-Cardo C, Peters G, Beach D, Lowe SW. Scott CL, et al. Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5389-94. doi: 10.1073/pnas.0608721104. Epub 2007 Mar 20. Proc Natl Acad Sci U S A. 2007. PMID: 17374722 Free PMC article.
Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts.
Alcorta DA, Xiong Y, Phelps D, Hannon G, Beach D, Barrett JC. Alcorta DA, et al. Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13742-7. doi: 10.1073/pnas.93.24.13742. Proc Natl Acad Sci U S A. 1996. PMID: 8943005 Free PMC article.
Alteration of cell cycle kinase complexes in human papillomavirus E6- and E7-expressing fibroblasts precedes neoplastic transformation.
Xiong Y, Kuppuswamy D, Li Y, Livanos EM, Hixon M, White A, Beach D, Tlsty TD. Xiong Y, et al. J Virol. 1996 Feb;70(2):999-1008. doi: 10.1128/JVI.70.2.999-1008.1996. J Virol. 1996. PMID: 8551641 Free PMC article.
Expression of both human papillomavirus type 16 oncoproteins, E6 and E7, in normal human fibroblasts completely dissociates p21 and proliferating cell nuclear antigen from the quarternary cyclin-cyclin-dependent kinase (CDK) complexes present in normal cells, causes disruption of …
Expression of both human papillomavirus type 16 oncoproteins, E6 and E7, in normal human fibroblasts completely dissociates p21 and prolifer …
Mutations associated with familial melanoma impair p16INK4 function.
Ranade K, Hussussian CJ, Sikorski RS, Varmus HE, Goldstein AM, Tucker MA, Serrano M, Hannon GJ, Beach D, Dracopoli NC. Ranade K, et al. Nat Genet. 1995 May;10(1):114-6. doi: 10.1038/ng0595-114. Nat Genet. 1995. PMID: 7647780
A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma.
Wölfel T, Hauer M, Schneider J, Serrano M, Wölfel C, Klehmann-Hieb E, De Plaen E, Hankeln T, Meyer zum Büschenfelde KH, Beach D. Wölfel T, et al. Science. 1995 Sep 1;269(5228):1281-4. doi: 10.1126/science.7652577. Science. 1995. PMID: 7652577
Myc activates telomerase.
Wang J, Xie LY, Allan S, Beach D, Hannon GJ. Wang J, et al. Genes Dev. 1998 Jun 15;12(12):1769-74. doi: 10.1101/gad.12.12.1769. Genes Dev. 1998. PMID: 9637678 Free PMC article.
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