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DNA hypomethylation leads to elevated mutation rates.
Chen RZ, Pettersson U, Beard C, Jackson-Grusby L, Jaenisch R. Chen RZ, et al. Among authors: beard c. Nature. 1998 Sep 3;395(6697):89-93. doi: 10.1038/25779. Nature. 1998. PMID: 9738504
Transgenic mice with defined combinations of drug-inducible reprogramming factors.
Markoulaki S, Hanna J, Beard C, Carey BW, Cheng AW, Lengner CJ, Dausman JA, Fu D, Gao Q, Wu S, Cassady JP, Jaenisch R. Markoulaki S, et al. Among authors: beard c. Nat Biotechnol. 2009 Feb;27(2):169-71. doi: 10.1038/nbt.1520. Epub 2009 Jan 18. Nat Biotechnol. 2009. PMID: 19151700 Free PMC article.
Proviruses carrying drug-inducible Oct4, Sox2, Klf4 and c-Myc used to derive 'primary' induced pluripotent stem (iPS) cells were segregated through germline transmission, generating mice and cells carrying subsets of the reprogramming factors. ...
Proviruses carrying drug-inducible Oct4, Sox2, Klf4 and c-Myc used to derive 'primary' induced pluripotent stem (iPS) cells were segr …
Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.
Opferman JT, Letai A, Beard C, Sorcinelli MD, Ong CC, Korsmeyer SJ. Opferman JT, et al. Among authors: beard c. Nature. 2003 Dec 11;426(6967):671-6. doi: 10.1038/nature02067. Nature. 2003. PMID: 14668867
Single-gene transgenic mouse strains for reprogramming adult somatic cells.
Carey BW, Markoulaki S, Beard C, Hanna J, Jaenisch R. Carey BW, et al. Among authors: beard c. Nat Methods. 2010 Jan;7(1):56-9. doi: 10.1038/nmeth.1410. Epub 2009 Dec 13. Nat Methods. 2010. PMID: 20010831 Free PMC article.
Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases.
Hockemeyer D, Soldner F, Beard C, Gao Q, Mitalipova M, DeKelver RC, Katibah GE, Amora R, Boydston EA, Zeitler B, Meng X, Miller JC, Zhang L, Rebar EJ, Gregory PD, Urnov FD, Jaenisch R. Hockemeyer D, et al. Among authors: beard c. Nat Biotechnol. 2009 Sep;27(9):851-7. doi: 10.1038/nbt.1562. Epub 2009 Aug 13. Nat Biotechnol. 2009. PMID: 19680244 Free PMC article.
Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency.
Hanna J, Markoulaki S, Schorderet P, Carey BW, Beard C, Wernig M, Creyghton MP, Steine EJ, Cassady JP, Foreman R, Lengner CJ, Dausman JA, Jaenisch R. Hanna J, et al. Among authors: beard c. Cell. 2008 Apr 18;133(2):250-64. doi: 10.1016/j.cell.2008.03.028. Cell. 2008. PMID: 18423197 Free PMC article.
We utilized transgenic and inducible expression of four transcription factors (Oct4, Sox2, Klf4, and c-Myc) to reprogram mouse B lymphocytes. ...However, reprogramming of mature B cells required additional interruption with the transcriptional state maintaining B cell iden …
We utilized transgenic and inducible expression of four transcription factors (Oct4, Sox2, Klf4, and c-Myc) to reprogram mouse B lymp …
Expression of oncogenic K-ras from its endogenous promoter leads to a partial block of erythroid differentiation and hyperactivation of cytokine-dependent signaling pathways.
Zhang J, Liu Y, Beard C, Tuveson DA, Jaenisch R, Jacks TE, Lodish HF. Zhang J, et al. Among authors: beard c. Blood. 2007 Jun 15;109(12):5238-41. doi: 10.1182/blood-2006-09-047050. Epub 2007 Feb 22. Blood. 2007. PMID: 17317860 Free PMC article.
Partial rescue of MeCP2 deficiency by postnatal activation of MeCP2.
Giacometti E, Luikenhuis S, Beard C, Jaenisch R. Giacometti E, et al. Among authors: beard c. Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1931-6. doi: 10.1073/pnas.0610593104. Epub 2007 Jan 31. Proc Natl Acad Sci U S A. 2007. PMID: 17267601 Free PMC article.
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