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Page 1
Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition.
Crespo-Garcia S, Tsuruda PR, Dejda A, Ryan RD, Fournier F, Chaney SY, Pilon F, Dogan T, Cagnone G, Patel P, Buscarlet M, Dasgupta S, Girouard G, Rao SR, Wilson AM, O'Brien R, Juneau R, Guber V, Dubrac A, Beausejour C, Armstrong S, Mallette FA, Yohn CB, Joyal JS, Marquess D, Beltran PJ, Sapieha P. Crespo-Garcia S, et al. Among authors: beausejour c. Cell Metab. 2021 Apr 6;33(4):818-832.e7. doi: 10.1016/j.cmet.2021.01.011. Epub 2021 Feb 5. Cell Metab. 2021. PMID: 33548171 Free article.
The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis.
Sapieha P, Sirinyan M, Hamel D, Zaniolo K, Joyal JS, Cho JH, Honoré JC, Kermorvant-Duchemin E, Varma DR, Tremblay S, Leduc M, Rihakova L, Hardy P, Klein WH, Mu X, Mamer O, Lachapelle P, Di Polo A, Beauséjour C, Andelfinger G, Mitchell G, Sennlaub F, Chemtob S. Sapieha P, et al. Among authors: beausejour c. Nat Med. 2008 Oct;14(10):1067-76. doi: 10.1038/nm.1873. Epub 2008 Oct 5. Nat Med. 2008. PMID: 18836459
Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A.
Joyal JS, Sitaras N, Binet F, Rivera JC, Stahl A, Zaniolo K, Shao Z, Polosa A, Zhu T, Hamel D, Djavari M, Kunik D, Honoré JC, Picard E, Zabeida A, Varma DR, Hickson G, Mancini J, Klagsbrun M, Costantino S, Beauséjour C, Lachapelle P, Smith LE, Chemtob S, Sapieha P. Joyal JS, et al. Among authors: beausejour c. Blood. 2011 Jun 2;117(22):6024-35. doi: 10.1182/blood-2010-10-311589. Epub 2011 Feb 25. Blood. 2011. PMID: 21355092 Free PMC article.
Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis.
Joyal JS, Nim S, Zhu T, Sitaras N, Rivera JC, Shao Z, Sapieha P, Hamel D, Sanchez M, Zaniolo K, St-Louis M, Ouellette J, Montoya-Zavala M, Zabeida A, Picard E, Hardy P, Bhosle V, Varma DR, Gobeil F Jr, Beauséjour C, Boileau C, Klein W, Hollenberg M, Ribeiro-da-Silva A, Andelfinger G, Chemtob S. Joyal JS, et al. Among authors: beausejour c. Nat Med. 2014 Oct;20(10):1165-73. doi: 10.1038/nm.3669. Epub 2014 Sep 14. Nat Med. 2014. PMID: 25216639
R-2-hydroxyglutarate-mediated inhibition of KDM4A compromises telomere integrity.
Couteau F, Gagné LM, Boulay K, Rousseau P, Carbonneau M, McQuaid M, Sharma J, Sawchyn C, Fernandez E, Glatz D, Rizk R, Lalonde ME, Mehrjoo Y, Chu TW, Moquin-Beaudry G, Beauséjour C, Sergeev M, Costantino S, Avizonis D, Topisirovic I, Jabado N, Wurtele H, Autexier C, Mallette FA. Couteau F, et al. Among authors: beausejour c. Nucleic Acids Res. 2025 Jun 6;53(11):gkaf512. doi: 10.1093/nar/gkaf512. Nucleic Acids Res. 2025. PMID: 40498073 Free PMC article.
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