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The interactions of histidine-containing amphipathic helical peptide antibiotics with lipid bilayers. The effects of charges and pH.
Vogt TC, Bechinger B. Vogt TC, et al. Among authors: bechinger b. J Biol Chem. 1999 Oct 8;274(41):29115-21. doi: 10.1074/jbc.274.41.29115. J Biol Chem. 1999. PMID: 10506166
The peptide is oriented parallel to the membrane surface under acidic conditions, but transmembrane at physiological pH (Bechinger, B. (1996) J. Mol. Biol. 263, 768-775). LAH(4) exhibits antibiotic activities against Escherichia coli and Bacillus subtilis; the pepti …
The peptide is oriented parallel to the membrane surface under acidic conditions, but transmembrane at physiological pH (Bechinger, …
180 results