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BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice.
Nishitomi K, Sakaguchi G, Horikoshi Y, Gray AJ, Maeda M, Hirata-Fukae C, Becker AG, Hosono M, Sakaguchi I, Minami SS, Nakajima Y, Li HF, Takeyama C, Kihara T, Ota A, Wong PC, Aisen PS, Kato A, Kinoshita N, Matsuoka Y. Nishitomi K, et al. Among authors: becker ag. J Neurochem. 2006 Dec;99(6):1555-63. doi: 10.1111/j.1471-4159.2006.04178.x. Epub 2006 Nov 2. J Neurochem. 2006. PMID: 17083447 Free article.
Antibody against C-terminal Abeta selectively elevates plasma Abeta.
Gray AJ, Sakaguchi G, Shiratori C, Becker AG, LaFrancois J, Aisen PS, Duff K, Matsuoka Y. Gray AJ, et al. Among authors: becker ag. Neuroreport. 2007 Feb 12;18(3):293-6. doi: 10.1097/WNR.0b013e3280148e76. Neuroreport. 2007. PMID: 17314674
Deglycosylated anti-amyloid beta antibodies reduce microglial phagocytosis and cytokine production while retaining the capacity to induce amyloid beta sequestration.
Takata K, Hirata-Fukae C, Becker AG, Chishiro S, Gray AJ, Nishitomi K, Franz AH, Sakaguchi G, Kato A, Mattson MP, Laferla FM, Aisen PS, Kitamura Y, Matsuoka Y. Takata K, et al. Among authors: becker ag. Eur J Neurosci. 2007 Nov;26(9):2458-68. doi: 10.1111/j.1460-9568.2007.05852.x. Epub 2007 Oct 23. Eur J Neurosci. 2007. PMID: 17970733
24 results