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Extensive natural variation for cellular hydrogen peroxide release is genetically controlled.
Attar H, Bedard K, Migliavacca E, Gagnebin M, Dupré Y, Descombes P, Borel C, Deutsch S, Prokisch H, Meitinger T, Mehta D, Wichmann E, Delabar JM, Dermitzakis ET, Krause KH, Antonarakis SE. Attar H, et al. Among authors: bedard k. PLoS One. 2012;7(8):e43566. doi: 10.1371/journal.pone.0043566. Epub 2012 Aug 29. PLoS One. 2012. PMID: 22952707 Free PMC article.
NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action.
Jaquet V, Marcoux J, Forest E, Leidal KG, McCormick S, Westermaier Y, Perozzo R, Plastre O, Fioraso-Cartier L, Diebold B, Scapozza L, Nauseef WM, Fieschi F, Krause KH, Bedard K. Jaquet V, et al. Among authors: bedard k. Br J Pharmacol. 2011 Sep;164(2b):507-20. doi: 10.1111/j.1476-5381.2011.01439.x. Br J Pharmacol. 2011. PMID: 21501142 Free PMC article.
NOX enzymes in immuno-inflammatory pathologies.
Krause KH, Bedard K. Krause KH, et al. Among authors: bedard k. Semin Immunopathol. 2008 Jul;30(3):193-4. doi: 10.1007/s00281-008-0127-2. Semin Immunopathol. 2008. PMID: 18560833 No abstract available.
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