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106 results

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Page 1
PDE5 inhibitor efficacy is estrogen dependent in female heart disease.
Sasaki H, Nagayama T, Blanton RM, Seo K, Zhang M, Zhu G, Lee DI, Bedja D, Hsu S, Tsukamoto O, Takashima S, Kitakaze M, Mendelsohn ME, Karas RH, Kass DA, Takimoto E. Sasaki H, et al. Among authors: bedja d. J Clin Invest. 2014 Jun;124(6):2464-71. doi: 10.1172/JCI70731. Epub 2014 May 16. J Clin Invest. 2014. PMID: 24837433 Free PMC article.
Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice.
Takimoto E, Koitabashi N, Hsu S, Ketner EA, Zhang M, Nagayama T, Bedja D, Gabrielson KL, Blanton R, Siderovski DP, Mendelsohn ME, Kass DA. Takimoto E, et al. Among authors: bedja d. J Clin Invest. 2009 Feb;119(2):408-20. doi: 10.1172/JCI35620. Epub 2009 Jan 5. J Clin Invest. 2009. PMID: 19127022 Free PMC article.
The mitochondrial regulator PGC1α is induced by cGMP-PKG signaling and mediates the protective effects of phosphodiesterase 5 inhibition in heart failure.
Zhu G, Ueda K, Hashimoto M, Zhang M, Sasaki M, Kariya T, Sasaki H, Kaludercic N, Lee DI, Bedja D, Gabrielson M, Yuan Y, Paolocci N, Blanton RM, Karas RH, Mendelsohn ME, O'Rourke B, Kass DA, Takimoto E. Zhu G, et al. Among authors: bedja d. FEBS Lett. 2022 Jan;596(1):17-28. doi: 10.1002/1873-3468.14228. Epub 2021 Nov 19. FEBS Lett. 2022. PMID: 34778969 Free PMC article.
Sildenafil stops progressive chamber, cellular, and molecular remodeling and improves calcium handling and function in hearts with pre-existing advanced hypertrophy caused by pressure overload.
Nagayama T, Hsu S, Zhang M, Koitabashi N, Bedja D, Gabrielson KL, Takimoto E, Kass DA. Nagayama T, et al. Among authors: bedja d. J Am Coll Cardiol. 2009 Jan 13;53(2):207-15. doi: 10.1016/j.jacc.2008.08.069. J Am Coll Cardiol. 2009. PMID: 19130990 Free PMC article.
Pathological cardiac hypertrophy alters intracellular targeting of phosphodiesterase type 5 from nitric oxide synthase-3 to natriuretic peptide signaling.
Zhang M, Takimoto E, Lee DI, Santos CX, Nakamura T, Hsu S, Jiang A, Nagayama T, Bedja D, Yuan Y, Eaton P, Shah AM, Kass DA. Zhang M, et al. Among authors: bedja d. Circulation. 2012 Aug 21;126(8):942-51. doi: 10.1161/CIRCULATIONAHA.112.090977. Epub 2012 Jul 24. Circulation. 2012. PMID: 22829024 Free PMC article.
Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease.
Lee DI, Zhu G, Sasaki T, Cho GS, Hamdani N, Holewinski R, Jo SH, Danner T, Zhang M, Rainer PP, Bedja D, Kirk JA, Ranek MJ, Dostmann WR, Kwon C, Margulies KB, Van Eyk JE, Paulus WJ, Takimoto E, Kass DA. Lee DI, et al. Among authors: bedja d. Nature. 2015 Mar 26;519(7544):472-6. doi: 10.1038/nature14332. Epub 2015 Mar 18. Nature. 2015. PMID: 25799991 Free PMC article.
106 results