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Hypomethylation and induction of retinoic acid receptor beta 2 by concurrent action of adenosine analogues and natural compounds in breast cancer cells.
Stefanska B, Rudnicka K, Bednarek A, Fabianowska-Majewska K. Stefanska B, et al. Eur J Pharmacol. 2010 Jul 25;638(1-3):47-53. doi: 10.1016/j.ejphar.2010.04.032. Epub 2010 May 3. Eur J Pharmacol. 2010. PMID: 20447390
All natural compounds improved the action of 2CdA and F-ara-A on RAR beta 2 methylation and/or expression. Combination of ATRA or vitamin D(3) with 2CdA was the most effective. In MDA-MB-231 cells, only 2CdA, F-ara-A, and ATRA induced RAR beta 2 expression without a …
All natural compounds improved the action of 2CdA and F-ara-A on RAR beta 2 methylation and/or expression. Combination of ATRA or vit …
Markers of epithelial-to-mesenchymal transition reflect tumor biology according to patient age and Gleason score in prostate cancer.
Jędroszka D, Orzechowska M, Hamouz R, Górniak K, Bednarek AK. Jędroszka D, et al. PLoS One. 2017 Dec 4;12(12):e0188842. doi: 10.1371/journal.pone.0188842. eCollection 2017. PLoS One. 2017. PMID: 29206234 Free PMC article.
It is well-known that androgen receptor (AR) plays a pivotal role in a vast majority of prostate tumors. However, recent evidence emerged stating that estrogen receptors (ERs) may also contribute to prostate tumor development. ...
It is well-known that androgen receptor (AR) plays a pivotal role in a vast majority of prostate tumors. However, recent evide …
The correlation analysis of WWOX expression and cancer related genes in neuroblastoma- a real time RT-PCR study.
Nowakowska M, Płuciennik E, Wujcicka WI, Sitkiewicz A, Kazanowska B, Zielińska E, Bednarek AK. Nowakowska M, et al. Acta Biochim Pol. 2014;61(1):91-7. Epub 2014 Jan 22. Acta Biochim Pol. 2014. PMID: 24455756
We found a positive correlation between WWOX gene and BCL2 and HER4 JM-a and negative with cyclin D1 and E1. Our observations are consistent with previous findings and emphasise the role of WWOX in cell cycle and apoptosis regulation. Moreover, strong positive assoc …
We found a positive correlation between WWOX gene and BCL2 and HER4 JM-a and negative with cyclin D1 and E1. Our observations …
Molecular analysis of WWOX expression correlation with proliferation and apoptosis in glioblastoma multiforme.
Kosla K, Pluciennik E, Kurzyk A, Jesionek-Kupnicka D, Kordek R, Potemski P, Bednarek AK. Kosla K, et al. J Neurooncol. 2011 Jan;101(2):207-13. doi: 10.1007/s11060-010-0254-1. Epub 2010 Jun 10. J Neurooncol. 2011. PMID: 20535528 Free PMC article.
WWOX is a tumor suppressor gene involved in carcinogenesis and cancer progression in many different neoplasms. Reduced WWOX expression is associated with more aggressive phenotype and poor patient outcome in several cancers. ...
WWOX is a tumor suppressor gene involved in carcinogenesis and cancer progression in many different neoplasms. Reduced WWOX expressio …
Effects of anthracycline derivatives on human leukemia K562 cell growth and differentiation.
Czyz M, Szulawska A, Bednarek AK, Düchler M. Czyz M, et al. Biochem Pharmacol. 2005 Nov 15;70(10):1431-42. doi: 10.1016/j.bcp.2005.08.010. Epub 2005 Sep 26. Biochem Pharmacol. 2005. PMID: 16185667
In cell cycle analysis, we have demonstrated that those anthracycline derivatives that exert the greatest cytostatic potential caused G(2)/M arrest, which in turn, might contribute to the development of a differentiating phenotype. ...
In cell cycle analysis, we have demonstrated that those anthracycline derivatives that exert the greatest cytostatic potential caused G(2)/M …
Common profiles of Notch signaling differentiate disease-free survival in luminal type A and triple negative breast cancer.
Orzechowska M, Jędroszka D, Bednarek AK. Orzechowska M, et al. Oncotarget. 2017 Jan 24;8(4):6013-6032. doi: 10.18632/oncotarget.13451. Oncotarget. 2017. PMID: 27888801 Free PMC article.
The Notch pathway regulates such processes as organ modeling and epithelial-to-mesenchymal transition (EMT).The aim of the study was to determine the effect of differential expression of Notch members on disease-free survival (DFS) in luminal type A (lumA) and triple negat …
The Notch pathway regulates such processes as organ modeling and epithelial-to-mesenchymal transition (EMT).The aim of the study was to dete …
Genetic alterations of WWOX in Wilms' tumor are involved in its carcinogenesis.
Płuciennik E, Nowakowska M, Wujcicka WI, Sitkiewicz A, Kazanowska B, Zielińska E, Bednarek AK. Płuciennik E, et al. Oncol Rep. 2012 Oct;28(4):1417-22. doi: 10.3892/or.2012.1940. Epub 2012 Jul 27. Oncol Rep. 2012. PMID: 22842668
We revealed a positive correlation between WWOX expression and BCL2, BCL2/BAX ratio, EGFR, ERBB4 isoform JM-a, TP73 and negative correlation with both cyclins. ...
We revealed a positive correlation between WWOX expression and BCL2, BCL2/BAX ratio, EGFR, ERBB4 isoform JM-a, TP73 and negati …
Breast cancer relapse prediction based on multi-gene RT-PCR algorithm.
Pluciennik E, Krol M, Nowakowska M, Kusinska R, Potemski P, Kordek R, Bednarek AK. Pluciennik E, et al. Med Sci Monit. 2010 Mar;16(3):CR132-136. Med Sci Monit. 2010. PMID: 20190683
However, when patients were divided into 2 groups according to estrogen receptor status, this algorithm could be applied only for a group with estrogen receptor negative breast cancer. High algorithm value is a good prognostic factor of disease-free survival for pat …
However, when patients were divided into 2 groups according to estrogen receptor status, this algorithm could be applied only for a g …
Silencing of Wnt-1 by siRNA induces apoptosis of MCF-7 human breast cancer cells.
Wieczorek M, Paczkowska A, Guzenda P, Majorek M, Bednarek AK, Lamparska-Przybysz M. Wieczorek M, et al. Cancer Biol Ther. 2008 Feb;7(2):268-74. doi: 10.4161/cbt.7.2.5300. Epub 2007 Nov 14. Cancer Biol Ther. 2008. PMID: 18059186
Aberrant activation of the Wnt/beta-catenin signaling pathway is associated with a variety of human cancers. In human breast cancer, evidence of beta-catenin accumulation implies that the canonical Wnt signaling pathway is active in over 50% of carcinomas. ...CONCLUSION: O …
Aberrant activation of the Wnt/beta-catenin signaling pathway is associated with a variety of human cancers. In human breast cancer, …
Comparative effects of retinoic acid, vitamin D and resveratrol alone and in combination with adenosine analogues on methylation and expression of phosphatase and tensin homologue tumour suppressor gene in breast cancer cells.
Stefanska B, Salamé P, Bednarek A, Fabianowska-Majewska K. Stefanska B, et al. Br J Nutr. 2012 Mar;107(6):781-90. doi: 10.1017/S0007114511003631. Epub 2011 Aug 1. Br J Nutr. 2012. PMID: 21801466
It was associated with PTEN induction as well as DNA methyltransferase down-regulation and p21 up-regulation after treatments with vitamin D₃ and resveratrol, suggesting a complex regulation of the DNA methylation machinery. Vitamin D₃ and resveratrol improved the inhibito …
It was associated with PTEN induction as well as DNA methyltransferase down-regulation and p21 up-regulation after treatments with vitamin D …
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