Abstract
Whole-cell and isolated patch configurations of the patch clamp technique were used to distinguish K+-channels by their pharmacological characteristics in single, enzymatically dispersed, smooth muscle cells from the rabbit portal vein. Results suggest that spontaneous transient outward currents are carried mainly by large conductance Ca2+-activated K+-channels and outward current evoked by depolarization of the membrane is carried partially by these channels but also by a time- and potential-dependent K+-channel blocked by 4-aminopyridine.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
4-Aminopyridine
-
Aminopyridines / pharmacology
-
Animals
-
In Vitro Techniques
-
Ion Channels / drug effects*
-
Ion Channels / metabolism
-
Membrane Potentials / drug effects
-
Muscle, Smooth, Vascular / drug effects*
-
Muscle, Smooth, Vascular / metabolism
-
Potassium / metabolism*
-
Quinidine / pharmacology
-
Rabbits
-
Tetraethylammonium
-
Tetraethylammonium Compounds / pharmacology
Substances
-
Aminopyridines
-
Ion Channels
-
Tetraethylammonium Compounds
-
Tetraethylammonium
-
4-Aminopyridine
-
Quinidine
-
Potassium