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Delineating the genetic basis of systemic lupus erythematosus.
Wakeland EK, Liu K, Graham RR, Behrens TW. Wakeland EK, et al. Among authors: behrens tw. Immunity. 2001 Sep;15(3):397-408. doi: 10.1016/s1074-7613(01)00201-1. Immunity. 2001. PMID: 11567630 Review.
Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus.
Cunninghame Graham DS, Graham RR, Manku H, Wong AK, Whittaker JC, Gaffney PM, Moser KL, Rioux JD, Altshuler D, Behrens TW, Vyse TJ. Cunninghame Graham DS, et al. Among authors: behrens tw. Nat Genet. 2008 Jan;40(1):83-9. doi: 10.1038/ng.2007.47. Epub 2007 Dec 2. Nat Genet. 2008. PMID: 18059267 Free PMC article.
CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation.
Manjarrez-Orduño N, Marasco E, Chung SA, Katz MS, Kiridly JF, Simpfendorfer KR, Freudenberg J, Ballard DH, Nashi E, Hopkins TJ, Cunninghame Graham DS, Lee AT, Coenen MJ, Franke B, Swinkels DW, Graham RR, Kimberly RP, Gaffney PM, Vyse TJ, Behrens TW, Criswell LA, Diamond B, Gregersen PK. Manjarrez-Orduño N, et al. Among authors: behrens tw. Nat Genet. 2012 Nov;44(11):1227-30. doi: 10.1038/ng.2439. Epub 2012 Oct 7. Nat Genet. 2012. PMID: 23042117 Free PMC article.
Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus.
Bentham J, Morris DL, Graham DSC, Pinder CL, Tombleson P, Behrens TW, Martín J, Fairfax BP, Knight JC, Chen L, Replogle J, Syvänen AC, Rönnblom L, Graham RR, Wither JE, Rioux JD, Alarcón-Riquelme ME, Vyse TJ. Bentham J, et al. Among authors: behrens tw. Nat Genet. 2015 Dec;47(12):1457-1464. doi: 10.1038/ng.3434. Epub 2015 Oct 26. Nat Genet. 2015. PMID: 26502338 Free PMC article.
Thinking differently about lupus.
Wuster A, Behrens TW. Wuster A, et al. Among authors: behrens tw. Elife. 2016 Mar 29;5:e15352. doi: 10.7554/eLife.15352. Elife. 2016. PMID: 27023642 Free PMC article.
Association of endogenous anti-interferon-α autoantibodies with decreased interferon-pathway and disease activity in patients with systemic lupus erythematosus.
Morimoto AM, Flesher DT, Yang J, Wolslegel K, Wang X, Brady A, Abbas AR, Quarmby V, Wakshull E, Richardson B, Townsend MJ, Behrens TW. Morimoto AM, et al. Among authors: behrens tw. Arthritis Rheum. 2011 Aug;63(8):2407-15. doi: 10.1002/art.30399. Arthritis Rheum. 2011. PMID: 21506093 Free PMC article.
Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus.
Cunninghame Graham DS, Morris DL, Bhangale TR, Criswell LA, Syvänen AC, Rönnblom L, Behrens TW, Graham RR, Vyse TJ. Cunninghame Graham DS, et al. Among authors: behrens tw. PLoS Genet. 2011 Oct;7(10):e1002341. doi: 10.1371/journal.pgen.1002341. Epub 2011 Oct 27. PLoS Genet. 2011. PMID: 22046141 Free PMC article.
Self-reactive B lymphocytes overexpressing Bcl-xL escape negative selection and are tolerized by clonal anergy and receptor editing.
Fang W, Weintraub BC, Dunlap B, Garside P, Pape KA, Jenkins MK, Goodnow CC, Mueller DL, Behrens TW. Fang W, et al. Among authors: behrens tw. Immunity. 1998 Jul;9(1):35-45. doi: 10.1016/s1074-7613(00)80586-5. Immunity. 1998. PMID: 9697834
Baseline autoantibody profiles predict normalization of complement and anti-dsDNA autoantibody levels following rituximab treatment in systemic lupus erythematosus.
Tew GW, Rabbee N, Wolslegel K, Hsieh HJ, Monroe JG, Behrens TW, Brunetta PG, Keir ME. Tew GW, et al. Among authors: behrens tw. Lupus. 2010 Feb;19(2):146-57. doi: 10.1177/0961203309350752. Epub 2009 Nov 27. Lupus. 2010. PMID: 19946034
Review of recent genome-wide association scans in lupus.
Graham RR, Hom G, Ortmann W, Behrens TW. Graham RR, et al. Among authors: behrens tw. J Intern Med. 2009 Jun;265(6):680-8. doi: 10.1111/j.1365-2796.2009.02096.x. J Intern Med. 2009. PMID: 19493061 Review.
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