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Formatted anti-tumor necrosis factor alpha VHH proteins derived from camelids show superior potency and targeting to inflamed joints in a murine model of collagen-induced arthritis.
Coppieters K, Dreier T, Silence K, de Haard H, Lauwereys M, Casteels P, Beirnaert E, Jonckheere H, Van de Wiele C, Staelens L, Hostens J, Revets H, Remaut E, Elewaut D, Rottiers P. Coppieters K, et al. Among authors: beirnaert e. Arthritis Rheum. 2006 Jun;54(6):1856-66. doi: 10.1002/art.21827. Arthritis Rheum. 2006. PMID: 16736523 Free article.
The preclinical pharmacology of the high affinity anti-IL-6R Nanobody® ALX-0061 supports its clinical development in rheumatoid arthritis.
Van Roy M, Ververken C, Beirnaert E, Hoefman S, Kolkman J, Vierboom M, Breedveld E, 't Hart B, Poelmans S, Bontinck L, Hemeryck A, Jacobs S, Baumeister J, Ulrichts H. Van Roy M, et al. Among authors: beirnaert e. Arthritis Res Ther. 2015 May 20;17(1):135. doi: 10.1186/s13075-015-0651-0. Arthritis Res Ther. 2015. PMID: 25994180 Free PMC article.
Llama antibody fragments with cross-subtype human immunodeficiency virus type 1 (HIV-1)-neutralizing properties and high affinity for HIV-1 gp120.
Forsman A, Beirnaert E, Aasa-Chapman MM, Hoorelbeke B, Hijazi K, Koh W, Tack V, Szynol A, Kelly C, McKnight A, Verrips T, de Haard H, Weiss RA. Forsman A, et al. Among authors: beirnaert e. J Virol. 2008 Dec;82(24):12069-81. doi: 10.1128/JVI.01379-08. Epub 2008 Oct 8. J Virol. 2008. PMID: 18842738 Free PMC article.
Nanobodies®: new ammunition to battle viruses.
Vanlandschoot P, Stortelers C, Beirnaert E, Ibañez LI, Schepens B, Depla E, Saelens X. Vanlandschoot P, et al. Among authors: beirnaert e. Antiviral Res. 2011 Dec;92(3):389-407. doi: 10.1016/j.antiviral.2011.09.002. Epub 2011 Sep 10. Antiviral Res. 2011. PMID: 21939690 Review.
23 results