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A functional variant in APOA5/A4/C3/A1 gene cluster contributes to elevated triglycerides and severity of CAD by interfering with microRNA 3201 binding efficiency.
Cui G, Li Z, Li R, Huang J, Wang H, Zhang L, Ding H, Wang DW. Cui G, et al. J Am Coll Cardiol. 2014 Jul 22;64(3):267-77. doi: 10.1016/j.jacc.2014.03.050. J Am Coll Cardiol. 2014. PMID: 25034063 Free article.
BACKGROUND: Recent genome-wide association studies identified the APOA5/A4/C3/A1 gene cluster polymorphisms influencing triglyceride level and risk of coronary artery disease (CAD). ...METHODS: We resequenced the APOA5/A4/C3/A1 gene cluster in 200 pati …
BACKGROUND: Recent genome-wide association studies identified the APOA5/A4/C3/A1 gene cluster polymorphisms influencing trigly …
Rs964184 (APOA5-A4-C3-A1) is related to elevated plasma triglyceride levels, but not to an increased risk for vascular events in patients with clinically manifest vascular disease.
van de Woestijne AP, van der Graaf Y, de Bakker PI, Asselbergs FW, Spiering W, Visseren FL; SMART Study Group. van de Woestijne AP, et al. PLoS One. 2014 Jun 30;9(6):e101082. doi: 10.1371/journal.pone.0101082. eCollection 2014. PLoS One. 2014. PMID: 24979386 Free PMC article.
BACKGROUND: Single nucleotide polymorphisms in the APOA5-A4-C3-A1 gene complex are associated with elevated plasma triglycerides and elevated vascular risk in healthy populations. ...CONCLUSION: The single nucleotide polymorphism rs964184 (APOA5-A4-C3-A1 …
BACKGROUND: Single nucleotide polymorphisms in the APOA5-A4-C3-A1 gene complex are associated with elevated plasma triglycerid …
APOA5 Q97X mutation identified through homozygosity mapping causes severe hypertriglyceridemia in a Chilean consanguineous family.
Dussaillant C, Serrano V, Maiz A, Eyheramendy S, Cataldo LR, Chavez M, Smalley SV, Fuentes M, Rigotti A, Rubio L, Lagos CF, Martinez JA, Santos JL. Dussaillant C, et al. BMC Med Genet. 2012 Nov 15;13:106. doi: 10.1186/1471-2350-13-106. BMC Med Genet. 2012. PMID: 23151256 Free PMC article.
However, a number of severe HTG cases are probably caused by as yet unidentified mutations. Very high triglyceride plasma levels (>112 mmol/L at diagnosis) were found in two sisters of a Chilean consanguineous family, which is strongly suggestive of a recessive highly p …
However, a number of severe HTG cases are probably caused by as yet unidentified mutations. Very high triglyceride plasma levels (>112 mm …
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD; ASCOT investigators; NORDIL investigators; BRIGHT Consortium. Talmud PJ, et al. Am J Hum Genet. 2009 Nov;85(5):628-42. doi: 10.1016/j.ajhg.2009.10.014. Am J Hum Genet. 2009. PMID: 19913121 Free PMC article.
SNPs associated with LDL cholesterol and apolipoprotein B were located in LDLR, PCSK9, APOB, CELSR2, HMGCR, CETP, the TOMM40-APOE-C1-C2-C4 cluster, and the APOA5-A4-C3-A1 cluster; SNPs associated with HDL cholesterol and apolipoprotein AI were in CETP, LPL, LIPC, AP …
SNPs associated with LDL cholesterol and apolipoprotein B were located in LDLR, PCSK9, APOB, CELSR2, HMGCR, CETP, the TOMM40-APOE-C1-C2-C4 c …
SNPs at the APOA5 gene account for the strong association with hypertriglyceridaemia at the APOA5/A4/C3/A1 locus on chromosome 11q23 in the Northern Irish population.
Wright WT, Young IS, Nicholls DP, Patterson C, Lyttle K, Graham CA. Wright WT, et al. Atherosclerosis. 2006 Apr;185(2):353-60. doi: 10.1016/j.atherosclerosis.2005.06.043. Epub 2005 Aug 25. Atherosclerosis. 2006. PMID: 16125709

The apolipoproteins C-III (apoCIII) and A-V (apoAV) are central to normal TG metabolism and the complete sequence analysis of these genes was carried out in severe cases (TG > 9 mmol/l) and controls (TG < 2 mmol/l). A total of 53 SNPs were identified in these

…
The apolipoproteins C-III (apoCIII) and A-V (apoAV) are central to normal TG metabolism and the complete sequence analysis of these genes wa …
Characteristics of six isoperoxidases from Korean radish root.
Lee MY, Kim SS. Lee MY, et al. Phytochemistry. 1994 Jan;35(2):287-90. doi: 10.1016/s0031-9422(00)94749-6. Phytochemistry. 1994. PMID: 7764479
Two cationic isoperoxidases (designated C1 and C3) and four anionic isoperoxidases (designated A1, A2, A3n and A3) from Korean radish (Raphanus sativus L.) root have been purified to apparent homogeneity, and some of their enzymatic properties were characterized. All six i …
Two cationic isoperoxidases (designated C1 and C3) and four anionic isoperoxidases (designated A1, A2, A3n and A3) from Korean radish (Rapha …