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Protein disulfide isomerase regulation by nitric oxide maintains vascular quiescence and controls thrombus formation.
Bekendam RH, Iyu D, Passam F, Stopa JD, De Ceunynck K, Muse O, Bendapudi PK, Garnier CL, Gopal S, Crescence L, Chiu J, Furie B, Panicot-Dubois L, Hogg PJ, Dubois C, Flaumenhaft R. Bekendam RH, et al. J Thromb Haemost. 2018 Nov;16(11):2322-2335. doi: 10.1111/jth.14291. Epub 2018 Oct 12. J Thromb Haemost. 2018. PMID: 30207066 Free PMC article.
Inhibition of Protein Disulfide Isomerase in Thrombosis.
Bekendam RH, Flaumenhaft R. Bekendam RH, et al. Basic Clin Pharmacol Toxicol. 2016 Oct;119 Suppl 3:42-48. doi: 10.1111/bcpt.12573. Epub 2016 Mar 23. Basic Clin Pharmacol Toxicol. 2016. PMID: 26919268 Free article. Review.
A substrate-driven allosteric switch that enhances PDI catalytic activity.
Bekendam RH, Bendapudi PK, Lin L, Nag PP, Pu J, Kennedy DR, Feldenzer A, Chiu J, Cook KM, Furie B, Huang M, Hogg PJ, Flaumenhaft R. Bekendam RH, et al. Nat Commun. 2016 Aug 30;7:12579. doi: 10.1038/ncomms12579. Nat Commun. 2016. PMID: 27573496 Free PMC article.
Assays of Thiol Isomerase Enzymatic Activity.
Bekendam RH, Flaumenhaft R. Bekendam RH, et al. Methods Mol Biol. 2019;1967:133-148. doi: 10.1007/978-1-4939-9187-7_8. Methods Mol Biol. 2019. PMID: 31069768
Platelet Dysfunction and Thrombosis in JAK2V617F-Mutated Primary Myelofibrotic Mice.
Matsuura S, Thompson CR, Belghasem ME, Bekendam RH, Piasecki A, Leiva O, Ray A, Italiano J, Yang M, Merill-Skoloff G, Chitalia VC, Flaumenhaft R, Ravid K. Matsuura S, et al. Among authors: bekendam rh. Arterioscler Thromb Vasc Biol. 2020 Oct;40(10):e262-e272. doi: 10.1161/ATVBAHA.120.314760. Epub 2020 Aug 20. Arterioscler Thromb Vasc Biol. 2020. PMID: 32814440 Free PMC article.