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Modifying the protease, antiprotease pattern by elafin overexpression protects mice from colitis.
Motta JP, Magne L, Descamps D, Rolland C, Squarzoni-Dale C, Rousset P, Martin L, Cenac N, Balloy V, Huerre M, Fröhlich LF, Jenne D, Wartelle J, Belaaouaj A, Mas E, Vinel JP, Alric L, Chignard M, Vergnolle N, Sallenave JM. Motta JP, et al. Among authors: belaaouaj a. Gastroenterology. 2011 Apr;140(4):1272-82. doi: 10.1053/j.gastro.2010.12.050. Epub 2011 Jan 1. Gastroenterology. 2011. PMID: 21199654
Neutrophil elastase-mediated increase in airway temperature during inflammation.
Schmidt A, Belaaouaj A, Bissinger R, Koller G, Malleret L, D'Orazio C, Facchinelli M, Schulte-Hubbert B, Molinaro A, Holst O, Hammermann J, Schniederjans M, Meyer KC, Damkiaer S, Piacentini G, Assael B, Bruce K, Häußler S, LiPuma JJ, Seelig J, Worlitzsch D, Döring G. Schmidt A, et al. Among authors: belaaouaj a. J Cyst Fibros. 2014 Dec;13(6):623-31. doi: 10.1016/j.jcf.2014.03.004. Epub 2014 Apr 6. J Cyst Fibros. 2014. PMID: 24713593 Free article.
Neutrophil elastase degrades cystic fibrosis transmembrane conductance regulator via calpains and disables channel function in vitro and in vivo.
Le Gars M, Descamps D, Roussel D, Saussereau E, Guillot L, Ruffin M, Tabary O, Hong SS, Boulanger P, Paulais M, Malleret L, Belaaouaj A, Edelman A, Huerre M, Chignard M, Sallenave JM. Le Gars M, et al. Among authors: belaaouaj a. Am J Respir Crit Care Med. 2013 Jan 15;187(2):170-9. doi: 10.1164/rccm.201205-0875OC. Epub 2012 Dec 6. Am J Respir Crit Care Med. 2013. PMID: 23220915
Structural characterization of mouse neutrophil serine proteases and identification of their substrate specificities: relevance to mouse models of human inflammatory diseases.
Kalupov T, Brillard-Bourdet M, Dadé S, Serrano H, Wartelle J, Guyot N, Juliano L, Moreau T, Belaaouaj A, Gauthier F. Kalupov T, et al. Among authors: belaaouaj a. J Biol Chem. 2009 Dec 4;284(49):34084-91. doi: 10.1074/jbc.M109.042903. Epub 2009 Oct 15. J Biol Chem. 2009. PMID: 19833730 Free PMC article.
Survival and differentiation defects contribute to neutropenia in glucose-6-phosphatase-β (G6PC3) deficiency in a model of mouse neutrophil granulocyte differentiation.
Gautam S, Kirschnek S, Gentle IE, Kopiniok C, Henneke P, Häcker H, Malleret L, Belaaouaj A, Häcker G. Gautam S, et al. Among authors: belaaouaj a. Cell Death Differ. 2013 Aug;20(8):1068-79. doi: 10.1038/cdd.2013.39. Epub 2013 May 17. Cell Death Differ. 2013. PMID: 23686134 Free PMC article.
45 results