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Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways.
Larue L, Bellacosa A. Larue L, et al. Among authors: bellacosa a. Oncogene. 2005 Nov 14;24(50):7443-54. doi: 10.1038/sj.onc.1209091. Oncogene. 2005. PMID: 16288291 Review.
Recently, activation of the phosphatidylinositol 3' kinase (PI3K)/AKT axis is emerging as a central feature of EMT. In this review, we discuss the role of PI3K/AKT pathways in EMT during development and cancer with a focus on E-cadherin regulation. Interactions betw …
Recently, activation of the phosphatidylinositol 3' kinase (PI3K)/AKT axis is emerging as a central feature of EMT. In this review, w …
Thymine DNA glycosylase as a novel target for melanoma.
Mancuso P, Tricarico R, Bhattacharjee V, Cosentino L, Kadariya Y, Jelinek J, Nicolas E, Einarson M, Beeharry N, Devarajan K, Katz RA, Dorjsuren DG, Sun H, Simeonov A, Giordano A, Testa JR, Davidson G, Davidson I, Larue L, Sobol RW, Yen TJ, Bellacosa A. Mancuso P, et al. Among authors: bellacosa a. Oncogene. 2019 May;38(19):3710-3728. doi: 10.1038/s41388-018-0640-2. Epub 2019 Jan 23. Oncogene. 2019. PMID: 30674989 Free PMC article.
The proteins encoded by c-akt and v-akt differ in post-translational modification, subcellular localization and oncogenic potential.
Ahmed NN, Franke TF, Bellacosa A, Datta K, Gonzalez-Portal ME, Taguchi T, Testa JR, Tsichlis PN. Ahmed NN, et al. Among authors: bellacosa a. Oncogene. 1993 Jul;8(7):1957-63. Oncogene. 1993. PMID: 8510938
The oncogene carried by this virus, v-akt, arose by recombination between Gag and the 5' untranslated region of the cellular gene c-akt. v-akt encodes a 105 kilodalton (kd) Gag-Akt fusion protein which is phosphorylated on serine and threonine residues. c-akt encodes a
The oncogene carried by this virus, v-akt, arose by recombination between Gag and the 5' untranslated region of the cellular gene c-akt. v-a …
Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implications.
Bellacosa A, Franke TF, Gonzalez-Portal ME, Datta K, Taguchi T, Gardner J, Cheng JQ, Testa JR, Tsichlis PN. Bellacosa A, et al. Oncogene. 1993 Mar;8(3):745-54. Oncogene. 1993. PMID: 8437858
Sequence analysis of a nearly full-length murine c-akt cDNA clone and comparison with v-akt revealed the following: (a) The entire coding region of c-akt is identical to that of v-akt with the exception of five G to A transitions that do not alter the reading …
Sequence analysis of a nearly full-length murine c-akt cDNA clone and comparison with v-akt revealed the following: (a) The en …
The akt kinase: molecular determinants of oncogenicity.
Aoki M, Batista O, Bellacosa A, Tsichlis P, Vogt PK. Aoki M, et al. Among authors: bellacosa a. Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14950-5. doi: 10.1073/pnas.95.25.14950. Proc Natl Acad Sci U S A. 1998. PMID: 9843996 Free PMC article.
The serine-threonine kinase Akt is a downstream target of phosphoinositide 3-kinase (PI 3-kinase); it is activated by the phosphoinositide 3-phosphate-dependent kinases PDK1 and PDK2. ...A transdominant negative form of Akt interferes with oncogenic transformation i …
The serine-threonine kinase Akt is a downstream target of phosphoinositide 3-kinase (PI 3-kinase); it is activated by the phosphoinos …
Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase.
Ahmed NN, Grimes HL, Bellacosa A, Chan TO, Tsichlis PN. Ahmed NN, et al. Among authors: bellacosa a. Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3627-32. doi: 10.1073/pnas.94.8.3627. Proc Natl Acad Sci U S A. 1997. PMID: 9108028 Free PMC article.
Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells.
Datta K, Bellacosa A, Chan TO, Tsichlis PN. Datta K, et al. Among authors: bellacosa a. J Biol Chem. 1996 Nov 29;271(48):30835-9. doi: 10.1074/jbc.271.48.30835. J Biol Chem. 1996. PMID: 8940066
The Akt protooncogene encodes a serine-threonine protein kinase which is activated by growth factor-generated signals that are transduced via the phosphatidylinositol 3'-kinase (PI3-K). ...On the basis of these studies, it was hypothesized that Akt is a direct PI3-K …
The Akt protooncogene encodes a serine-threonine protein kinase which is activated by growth factor-generated signals that are transd …
AKT plays a central role in tumorigenesis.
Testa JR, Bellacosa A. Testa JR, et al. Among authors: bellacosa a. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):10983-5. doi: 10.1073/pnas.211430998. Proc Natl Acad Sci U S A. 2001. PMID: 11572954 Free PMC article. Review. No abstract available.
Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways.
Xiao GH, Jeffers M, Bellacosa A, Mitsuuchi Y, Vande Woude GF, Testa JR. Xiao GH, et al. Among authors: bellacosa a. Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):247-52. doi: 10.1073/pnas.011532898. Proc Natl Acad Sci U S A. 2001. PMID: 11134526 Free PMC article.
Akt is also activated by active tumorigenic forms of Met, i.e., ligand-independent Tpr-Met, a truncated and constitutively dimerized form of Met, and a mutationally activated version of Met corresponding to that found in human hereditary papillary renal carcinoma. . …
Akt is also activated by active tumorigenic forms of Met, i.e., ligand-independent Tpr-Met, a truncated and constitutively dimerized …
Akt activation by growth factors is a multiple-step process: the role of the PH domain.
Bellacosa A, Chan TO, Ahmed NN, Datta K, Malstrom S, Stokoe D, McCormick F, Feng J, Tsichlis P. Bellacosa A, et al. Oncogene. 1998 Jul 23;17(3):313-25. doi: 10.1038/sj.onc.1201947. Oncogene. 1998. PMID: 9690513
Transient transfection of NIH3T3 cells with wild-type Akt, pleckstrin homology (PH) domain mutants, generated on the basis of a PH domain structural model, and phosphorylation site Akt mutants provided evidence for a model of Akt activation consisting of three seque …
Transient transfection of NIH3T3 cells with wild-type Akt, pleckstrin homology (PH) domain mutants, generated on the basis of a PH do …
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