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Rapid chemical antagonism of neuromuscular blockade by L-cysteine adduction to and inactivation of the olefinic (double-bonded) isoquinolinium diester compounds gantacurium (AV430A), CW 002, and CW 011.
Savarese JJ, McGilvra JD, Sunaga H, Belmont MR, Van Ornum SG, Savard PM, Heerdt PM. Savarese JJ, et al. Among authors: belmont mr. Anesthesiology. 2010 Jul;113(1):58-73. doi: 10.1097/ALN.0b013e3181dc1b5b. Anesthesiology. 2010. PMID: 20526187 Free article.
Clinical pharmacology of GW280430A in humans.
Belmont MR, Lien CA, Tjan J, Bradley E, Stein B, Patel SS, Savarese JJ. Belmont MR, et al. Anesthesiology. 2004 Apr;100(4):768-73. doi: 10.1097/00000542-200404000-00004. Anesthesiology. 2004. PMID: 15087609 Free article.
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