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Regulation of TNF-alpha- and IFN-gamma-induced CXCL10 expression: participation of the airway smooth muscle in the pulmonary inflammatory response in chronic obstructive pulmonary disease.
Hardaker EL, Bacon AM, Carlson K, Roshak AK, Foley JJ, Schmidt DB, Buckley PT, Comegys M, Panettieri RA Jr, Sarau HM, Belmonte KE. Hardaker EL, et al. Among authors: belmonte ke. FASEB J. 2004 Jan;18(1):191-3. doi: 10.1096/fj.03-0170fje. Epub 2003 Nov 3. FASEB J. 2004. PMID: 14597565
Discovery of (3-endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide as an efficacious inhaled muscarinic acetylcholine receptor antagonist for the treatment of COPD.
Wan Z, Laine DI, Yan H, Zhu C, Widdowson KL, Buckley PT, Burman M, Foley JJ, Sarau HM, Schmidt DB, Webb EF, Belmonte KE, Palovich M. Wan Z, et al. Among authors: belmonte ke. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4560-2. doi: 10.1016/j.bmcl.2009.07.006. Epub 2009 Jul 8. Bioorg Med Chem Lett. 2009. PMID: 19616944
M3 muscarinic acetylcholine receptor antagonists: SAR and optimization of bi-aryl amines.
Budzik B, Wang Y, Shi D, Wang F, Xie H, Wan Z, Zhu C, Foley JJ, Nuthulaganti P, Kallal LA, Sarau HM, Morrow DM, Moore ML, Rivero RA, Palovich M, Salmon M, Belmonte KE, Laine DI, Jin J. Budzik B, et al. Among authors: belmonte ke. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1686-90. doi: 10.1016/j.bmcl.2009.01.098. Epub 2009 Feb 4. Bioorg Med Chem Lett. 2009. PMID: 19243945
Muscarinic acetylcholine receptor antagonists: SAR and optimization of tyrosine ureas.
Jin J, Wang Y, Shi D, Wang F, Fu W, Davis RS, Jin Q, Foley JJ, Sarau HM, Morrow DM, Moore ML, Rivero RA, Palovich M, Salmon M, Belmonte KE, Busch-Petersen J. Jin J, et al. Among authors: belmonte ke. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5481-6. doi: 10.1016/j.bmcl.2008.09.020. Epub 2008 Sep 10. Bioorg Med Chem Lett. 2008. PMID: 18818072
Discovery of novel and long acting muscarinic acetylcholine receptor antagonists.
Jin J, Wang Y, Shi D, Wang F, Davis RS, Jin Q, Fu W, Foley JJ, Webb EF, Dehaas CJ, Berlanga M, Burman M, Sarau HM, Morrow DM, Rao P, Kallal LA, Moore ML, Rivero RA, Palovich M, Salmon M, Belmonte KE, Busch-Petersen J. Jin J, et al. Among authors: belmonte ke. J Med Chem. 2008 Aug 28;51(16):4866-9. doi: 10.1021/jm800634k. Epub 2008 Aug 5. J Med Chem. 2008. PMID: 18680280
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