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An improved and highly selective fluorescence assay for measuring phosphatidylserine decarboxylase activity.
Choi JY, Black R 3rd, Lee H, Di Giovanni J, Murphy RC, Ben Mamoun C, Voelker DR. Choi JY, et al. Among authors: ben mamoun c. J Biol Chem. 2020 Jul 3;295(27):9211-9222. doi: 10.1074/jbc.RA120.013421. Epub 2020 May 19. J Biol Chem. 2020. PMID: 32430397
Anti-PfGARP activates programmed cell death of parasites and reduces severe malaria.
Raj DK, Das Mohapatra A, Jnawali A, Zuromski J, Jha A, Cham-Kpu G, Sherman B, Rudlaff RM, Nixon CE, Hilton N, Oleinikov AV, Chesnokov O, Merritt J, Pond-Tor S, Burns L, Jolly G, Ben Mamoun C, Kabyemela E, Muehlenbachs A, Lambert L, Orr-Gonzalez S, Gnädig NF, Fidock DA, Park S, Dvorin JD, Pardi N, Weissman D, Mui BL, Tam YK, Friedman JF, Fried M, Duffy PE, Kurtis JD. Raj DK, et al. Among authors: ben mamoun c. Nature. 2020 Jun;582(7810):104-108. doi: 10.1038/s41586-020-2220-1. Epub 2020 Apr 22. Nature. 2020. PMID: 32427965
Efficient Single-Gene and Gene Family Editing in the Apicomplexan Parasite Eimeria tenella Using CRISPR-Cas9.
Hu D, Tang X, Ben Mamoun C, Wang C, Wang S, Gu X, Duan C, Zhang S, Suo J, Deng M, Yu Y, Suo X, Liu X. Hu D, et al. Among authors: ben mamoun c. Front Bioeng Biotechnol. 2020 Feb 25;8:128. doi: 10.3389/fbioe.2020.00128. eCollection 2020. Front Bioeng Biotechnol. 2020. PMID: 32158750 Free PMC article.
The yeast pantothenate kinase Cab1 is a master regulator of sterol metabolism and of susceptibility to ergosterol biosynthesis inhibitors.
Chiu JE, Thekkiniath J, Mehta S, Müller C, Bracher F, Ben Mamoun C. Chiu JE, et al. Among authors: ben mamoun c. J Biol Chem. 2019 Oct 4;294(40):14757-14767. doi: 10.1074/jbc.RA119.009791. Epub 2019 Aug 13. J Biol Chem. 2019. PMID: 31409644
High-throughput screening for phosphatidylserine decarboxylase inhibitors using a distyrylbenzene-bis-aldehyde (DSB-3)-based fluorescence assay.
Hendricson A, Umlauf S, Choi JY, Thekkiniath J, Surovtseva YV, Fuller KK, Reynolds TB, Voelker DR, Ben Mamoun C. Hendricson A, et al. Among authors: ben mamoun c. J Biol Chem. 2019 Aug 9;294(32):12146-12156. doi: 10.1074/jbc.RA119.007766. Epub 2019 Jun 21. J Biol Chem. 2019. PMID: 31227523
Evidence for vesicle-mediated antigen export by the human pathogen Babesia microti.
Thekkiniath J, Kilian N, Lawres L, Gewirtz MA, Graham MM, Liu X, Ledizet M, Ben Mamoun C. Thekkiniath J, et al. Among authors: ben mamoun c. Life Sci Alliance. 2019 Jun 13;2(3):e201900382. doi: 10.26508/lsa.201900382. Print 2019 Jun. Life Sci Alliance. 2019. PMID: 31196872 Free PMC article.
Comparative 3D genome organization in apicomplexan parasites.
Bunnik EM, Venkat A, Shao J, McGovern KE, Batugedara G, Worth D, Prudhomme J, Lapp SA, Andolina C, Ross LS, Lawres L, Brady D, Sinnis P, Nosten F, Fidock DA, Wilson EH, Tewari R, Galinski MR, Ben Mamoun C, Ay F, Le Roch KG. Bunnik EM, et al. Among authors: ben mamoun c. Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3183-3192. doi: 10.1073/pnas.1810815116. Epub 2019 Feb 5. Proc Natl Acad Sci U S A. 2019. PMID: 30723152 Free PMC article.
Establishment of a continuous in vitro culture of Babesia duncani in human erythrocytes reveals unusually high tolerance to recommended therapies.
Abraham A, Brasov I, Thekkiniath J, Kilian N, Lawres L, Gao R, DeBus K, He L, Yu X, Zhu G, Graham MM, Liu X, Molestina R, Ben Mamoun C. Abraham A, et al. Among authors: ben mamoun c. J Biol Chem. 2018 Dec 28;293(52):19974-19981. doi: 10.1074/jbc.AC118.005771. Epub 2018 Nov 21. J Biol Chem. 2018. PMID: 30463941 Free PMC article.
A library of recombinant Babesia microti cell surface and secreted proteins for diagnostics discovery and reverse vaccinology.
Elton CM, Rodriguez M, Ben Mamoun C, Lobo CA, Wright GJ. Elton CM, et al. Among authors: ben mamoun c. Int J Parasitol. 2019 Feb;49(2):115-125. doi: 10.1016/j.ijpara.2018.10.003. Epub 2018 Oct 24. Int J Parasitol. 2019. PMID: 30367868 Free PMC article.
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