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1992 3
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Benarthin: a new inhibitor of pyroglutamyl peptidase. III. Synthesis and structure-activity relationships.
Hatsu M, Tuda M, Muraoka Y, Aoyagi T, Takeuchi T. Hatsu M, et al. J Antibiot (Tokyo). 1992 Jul;45(7):1088-95. doi: 10.7164/antibiotics.45.1088. J Antibiot (Tokyo). 1992. PMID: 1355473 Free article.
The structure of benarthin has been determined to be L-(2,3-dihydroxybenzoyl)arginyl-L-threonine. This structure was confirmed by the total synthesis of benarthin. ...The results indicated that the catechol group of benarthin is the essential moiety for the i …
The structure of benarthin has been determined to be L-(2,3-dihydroxybenzoyl)arginyl-L-threonine. This structure was confirmed by the …
Benarthin: a new inhibitor of pyroglutamyl peptidase. I. Taxonomy, fermentation, isolation and biological activities.
Aoyagi T, Hatsu M, Kojima F, Hayashi C, Hamada M, Takeuchi T. Aoyagi T, et al. J Antibiot (Tokyo). 1992 Jul;45(7):1079-83. doi: 10.7164/antibiotics.45.1079. J Antibiot (Tokyo). 1992. PMID: 1355471 Free article.
We found benarthin, a new inhibitor of pyroglutamyl peptidase, in the fermentation broth of Streptomyces xanthophaeus MJ244-SF1. It was purified by column chromatography and centrifugal partition chromatography (CPC) and then was isolated as a colorless powder. The binding …
We found benarthin, a new inhibitor of pyroglutamyl peptidase, in the fermentation broth of Streptomyces xanthophaeus MJ244-SF1. It w …
Benarthin: a new inhibitor of pyroglutamyl peptidase. II. Physico-chemical properties and structure determination.
Hatsu M, Naganawa H, Aoyagi T, Takeuchi T. Hatsu M, et al. J Antibiot (Tokyo). 1992 Jul;45(7):1084-7. doi: 10.7164/antibiotics.45.1084. J Antibiot (Tokyo). 1992. PMID: 1355472 Free article.
Benarthin, a new inhibitor of pyroglutamyl peptidase (PG-peptidase), has been isolated from the culture broth of Streptomyces xanthophaeus MJ244-SF1. The structure of benarthin was determined to be L-(2,3-dihydroxybenzoyl)argininyl-L-threonine by analysis of spectra …
Benarthin, a new inhibitor of pyroglutamyl peptidase (PG-peptidase), has been isolated from the culture broth of Streptomyces xanthop …
Multi-omics Study of Planobispora rosea, Producer of the Thiopeptide Antibiotic GE2270A.
Del Carratore F, Iorio M, Pérez-Bonilla M, Schmidt K, Pérez-Redondo R, Sosio M, Macdonald SJ, Gyulev IS, Tsigkinopoulou A, Thomas GH, Genilloud O, Rodríguez-García A, Donadio S, Breitling R, Takano E. Del Carratore F, et al. mSystems. 2021 Jun 29;6(3):e0034121. doi: 10.1128/mSystems.00341-21. Epub 2021 Jun 22. mSystems. 2021. PMID: 34156292 Free PMC article.
Additionally, we identified and validated a new biosynthetic gene cluster associated with the production of the siderophores benarthin and dibenarthin in P. rosea. Together, the metabolomics and transcriptomics data are used to inform and refine the very first genome-scale …
Additionally, we identified and validated a new biosynthetic gene cluster associated with the production of the siderophores benarthin …
Whole genome analysis of Bacillus amyloliquefaciens TA-1, a promising biocontrol agent against Cercospora arachidicola pathogen of early leaf spot in Arachis hypogaea L.
Wang C, Ahsan T, Ding A, Han D, Zang CQ, Huang YQ, Hussain K. Wang C, et al. BMC Plant Biol. 2023 Sep 4;23(1):410. doi: 10.1186/s12870-023-04423-4. BMC Plant Biol. 2023. PMID: 37667202 Free PMC article.
Gene function was annotated using non-redundant proteins from the National Center for Biotechnology Information (NCBI), Swiss-Prot, the Kyoto Encyclopedia of Genes and Genomes (KEGG), clusters of orthologous groups of proteins, gene ontology, pathogen-host interactions, and carbo …
Gene function was annotated using non-redundant proteins from the National Center for Biotechnology Information (NCBI), Swiss-Prot, the Kyot …
Whole genome analysis of Stenotrophomonas geniculata MK2 and antagonism against Botrytis cinerea in strawberry.
Mahnoor, Noor-Ul-Ain, Arshad F, Ahsan T, Alharbi SA, Ansari MJ, Khan I, Alshiekheid M, Sabour AAA. Mahnoor, et al. Int Microbiol. 2025 Aug;28(6):1255-1268. doi: 10.1007/s10123-024-00612-9. Epub 2024 Nov 27. Int Microbiol. 2025. PMID: 39602005
AntiSMASH analysis for biosynthesis-related gene clusters involved in the production of secondary metabolites showed ten gene clusters coded for 2,3-dihydroxybenzoylserine, griseobactin, fuscachelin, benarthin, mirubactin, myxochelin, and bacillibactin. The MK2 strain coul …
AntiSMASH analysis for biosynthesis-related gene clusters involved in the production of secondary metabolites showed ten gene clusters coded …
Streptobactin, a tricatechol-type siderophore from marine-derived Streptomyces sp. YM5-799.
Matsuo Y, Kanoh K, Jang JH, Adachi K, Matsuda S, Miki O, Kato T, Shizuri Y. Matsuo Y, et al. J Nat Prod. 2011 Nov 28;74(11):2371-6. doi: 10.1021/np200290j. Epub 2011 Oct 20. J Nat Prod. 2011. PMID: 22014204
The structure of streptobactin was determined by NMR and MS analyses and ESIMS/MS experiments to be a cyclic trimer of benarthin. A dibenarthin (2), a tribenarthin (3), and benarthin (4) were also obtained. ...
The structure of streptobactin was determined by NMR and MS analyses and ESIMS/MS experiments to be a cyclic trimer of benarthin. A d …
FASLG Derived from Fibroblasts in Hydroxyapatite-Rich Microenvironment Induces Urothelial Anoikis to Trigger Randall's Plaque Exposure.
Liu M, Wu M, Gao M, Li Y, Yuan M, Liao Z, Liu Z, Wang Y, Cui Y, Chen J, He C, Chen Z, Zeng F, Chen H, Zhu Z. Liu M, et al. Adv Sci (Weinh). 2026 Apr 2:e21605. doi: 10.1002/advs.202521605. Online ahead of print. Adv Sci (Weinh). 2026. PMID: 41926645
Moreover, the upregulated FASLG is identified as the predictor for recurrence in patients with CaOx stones following lithotripsy. Furthermore, Benarthin, a small compound binding to THY1, is found to inhibit HAP-induced FASLG and thus attenuate the anoikis of urothelium in …
Moreover, the upregulated FASLG is identified as the predictor for recurrence in patients with CaOx stones following lithotripsy. Furthermor …