Benbrook DM - Search Results

1

High performance liquid chromatographic analysis and preclinical pharmacokinetics of the heteroarotinoid antitumor agent, SHetA2.

Zhang Y, Hua Y, Benbrook DM, Covey JM, Dai G, Liu Z, Chan KK. Zhang Y, et al. Among authors: benbrook dm. Cancer Chemother Pharmacol. 2006 Nov;58(5):561-9. doi: 10.1007/s00280-006-0211-z. Epub 2006 Mar 14. Cancer Chemother Pharmacol. 2006. PMID: 16534614

2

Metabolism of a sulfur-containing heteroarotionoid antitumor agent, SHetA2, using liquid chromatography/tandem mass spectrometry.

Liu Z, Zhang Y, Hua YF, Covey JM, Benbrook DM, Chan KK. Liu Z, et al. Among authors: benbrook dm. Rapid Commun Mass Spectrom. 2008 Nov;22(21):3371-81. doi: 10.1002/rcm.3744. Rapid Commun Mass Spectrom. 2008. PMID: 18837006

3

Pharmacokinetics and interspecies scaling of a novel, orally-bioavailable anti-cancer drug, SHetA2.

Sharma A, Benbrook DM, Woo S. Sharma A, et al. Among authors: benbrook dm. PLoS One. 2018 Apr 10;13(4):e0194046. doi: 10.1371/journal.pone.0194046. eCollection 2018. PLoS One. 2018. PMID: 29634717 Free PMC article.

4

Physiologically Based Pharmacokinetic Modeling and Tissue Distribution Characteristics of SHetA2 in Tumor-Bearing Mice.

Sharma A, Li M, Thavathiru E, Ibrahim M, Garcia-Contreras L, Benbrook DM, Woo S. Sharma A, et al. Among authors: benbrook dm. AAPS J. 2020 Feb 21;22(2):51. doi: 10.1208/s12248-020-0421-z. AAPS J. 2020. PMID: 32086622 Free PMC article.

5

The synthetic heteroarotinoid SHetA2 induces apoptosis in squamous carcinoma cells through a receptor-independent and mitochondria-dependent pathway.

Chun KH, Benbrook DM, Berlin KD, Hong WK, Lotan R. Chun KH, et al. Among authors: benbrook dm. Cancer Res. 2003 Jul 1;63(13):3826-32. Cancer Res. 2003. PMID: 12839980

6

Development of a dietary formulation of the SHetA2 chemoprevention drug for mice.

Benbrook DM, Janakiram NB, Chandra V, Pathuri G, Madka V, Stratton NC, Masamha CP, Farnsworth CN, Garcia-Contreras L, Hatipoglu MK, Lighfoot S, Rao CV. Benbrook DM, et al. Invest New Drugs. 2018 Aug;36(4):561-570. doi: 10.1007/s10637-017-0550-0. Epub 2017 Dec 22. Invest New Drugs. 2018. PMID: 29273857 Free PMC article.

7

Oral toxicity and pharmacokinetic studies of SHetA2, a new chemopreventive agent, in rats and dogs.

Kabirov KK, Kapetanovic IM, Benbrook DM, Dinger N, Mankovskaya I, Zakharov A, Detrisac C, Pereira M, Martín-Jiménez T, Onua E, Banerjee A, van Breemen RB, Nikolić D, Chen L, Lyubimov AV. Kabirov KK, et al. Among authors: benbrook dm. Drug Chem Toxicol. 2013 Jul;36(3):284-95. doi: 10.3109/01480545.2012.710632. Epub 2012 Sep 5. Drug Chem Toxicol. 2013. PMID: 22947079

8

Vaginal Suppositories Containing SHetA2 to Treat Cervical Dysplasia: Pharmacokinetics of Daily Doses and Preliminary Safety Profile.

Mahjabeen S, Hatipoglu MK, Kosanke SD, Garcia-Contreras D, Benbrook DM, Garcia-Contreras L. Mahjabeen S, et al. Among authors: benbrook dm. J Pharm Sci. 2020 Jun;109(6):2000-2008. doi: 10.1016/j.xphs.2020.02.016. Epub 2020 Feb 27. J Pharm Sci. 2020. PMID: 32113976 Free PMC article.

9

Pharmacokinetics and Pharmacodynamics of Escalating Doses of SHetA2 After Vaginal Administration to Mice.

Mahjabeen S, Hatipoglu MK, Benbrook DM, Garcia-Contreras L. Mahjabeen S, et al. Among authors: benbrook dm. J Pharm Sci. 2018 Dec;107(12):3179-3186. doi: 10.1016/j.xphs.2018.08.024. Epub 2018 Sep 6. J Pharm Sci. 2018. PMID: 30196041 Free PMC article.

10

Synthesis and biological evaluation of SHetA2 (NSC-721689) analogs against the ovarian cancer cell line A2780.

Nammalwar B, Bunce RA, Berlin KD, Benbrook DM, Toal C. Nammalwar B, et al. Among authors: benbrook dm. Eur J Med Chem. 2019 May 15;170:16-27. doi: 10.1016/j.ejmech.2019.03.010. Epub 2019 Mar 7. Eur J Med Chem. 2019. PMID: 30878829

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