Benchmarking cryo-EM Single Particle Analysis Workflow.
Front Mol Biosci. 2018.
PMID: 29951483
Free PMC article.
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Benchmarking cryo-EM Single Particle Analysis Workflow.
Front Mol Biosci. 2018 Jun 4;5:50. doi: 10.3389/fmolb.2018.00050. eCollection 2018.
Front Mol Biosci. 2018.
PMID: 29951483
Free PMC article.
Cryo electron microscopy facilities running multiple instruments and serving users with varying skill levels need a robust and reliable method for benchmarking both the hardware and software components of their single particle analysis workflow. …
Cryo electron microscopy facilities running multiple instruments and serving users with varying skill levels need a robust and reliable meth …
Roodmus: a toolkit for benchmarking heterogeneous electron cryo-microscopy reconstructions.
IUCrJ. 2024 Nov 1;11(Pt 6):951-965. doi: 10.1107/S2052252524009321.
IUCrJ. 2024.
PMID: 39404610
Free PMC article.
Conformational heterogeneity of biological macromolecules is a challenge in single-particle averaging (SPA). Current standard practice is to employ classification and filtering methods that may allow a discrete number of conformational states to be reconstructed. .. …
Conformational heterogeneity of biological macromolecules is a challenge in single-particle averaging (SPA). Current standard …
AI tools for cryo-EM: Protein particle picking, density map enhancement, and atomic model building.
Prog Mol Biol Transl Sci. 2026;223:71-113. doi: 10.1016/bs.pmbts.2026.03.009. Epub 2026 Apr 14.
Prog Mol Biol Transl Sci. 2026.
PMID: 42463260
Review.
Single-particle cryo-electron microscopy (cryo-EM) has rapidly evolved from largely manual, stepwise workflows to AI-assisted, increasingly automated protein structure determination pipelines. ...Finally, we conclude by outlining open challenges …
Single-particle cryo-electron microscopy (cryo-EM) has rapidly evolved from largely manual, stepwise workflow …
MicrographCleaner: A python package for cryo-EM micrograph cleaning using deep learning.
J Struct Biol. 2020 Jun 1;210(3):107498. doi: 10.1016/j.jsb.2020.107498. Epub 2020 Apr 7.
J Struct Biol. 2020.
PMID: 32276087
Free article.
Cryo-EM Single Particle Analysis workflows require tens of thousands of high-quality particle projections to unveil the three-dimensional structure of macromolecules. Conventional methods for automatic particle picking tend …
Cryo-EM Single Particle Analysis workflows require tens of thousands of high-quality particle …
From molecular dynamics to cryo-EM: Imaging liposomes in silico.
Methods Enzymol. 2026;727:291-319. doi: 10.1016/bs.mie.2026.01.022. Epub 2026 Feb 4.
Methods Enzymol. 2026.
PMID: 41765595
Cryogenic electron microscopy (cryo-EM) has recently emerged as a powerful single-particle approach for characterizing the structure and organization of lipid bilayers at nanometer resolution. ...By enabling controlled, ground-truth comparisons between …
Cryogenic electron microscopy (cryo-EM) has recently emerged as a powerful single-particle approach for characte …
AlignPCA-2D: PCA-reduced Euclidean vector alignment for 2D classification in cryo-EM.
Acta Crystallogr D Struct Biol. 2026 Jul 1;82(Pt 7):727-739. doi: 10.1107/S2059798326004572. Epub 2026 Jun 8.
Acta Crystallogr D Struct Biol. 2026.
PMID: 42257246
Free PMC article.
However, the intrinsic heterogeneity and low signal-to-noise ratio of cryo-EM datasets make 2D classification a critical and computationally demanding step in the processing workflow. Here, we introduce AlignPCA-2D, a principal component analysis (PCA) …
However, the intrinsic heterogeneity and low signal-to-noise ratio of cryo-EM datasets make 2D classification a critical and c …
High-Resolution single particle analysis using a scintillator camera XF416 on CRYOARM300II at 300 kV.
J Struct Biol. 2026 Mar;218(1):108286. doi: 10.1016/j.jsb.2026.108286. Epub 2026 Jan 3.
J Struct Biol. 2026.
PMID: 41491063
The advent of direct electron detectors (DEDs) has driven a major breakthrough in cryo-electron microscopy (cryo-EM), particularly in single-particle analysis (SPA), establishing DEDs as essential tools for achieving near-atomic resolution. ...T …
The advent of direct electron detectors (DEDs) has driven a major breakthrough in cryo-electron microscopy (cryo-EM), particul …
An unattended image-processing pipeline for on-the-fly quality assessment and 3D exploration in cryo-EM.
Acta Crystallogr D Struct Biol. 2026 Aug 1;82(Pt 8):915-939. doi: 10.1107/S205979832600656X. Epub 2026 Jul 28.
Acta Crystallogr D Struct Biol. 2026.
PMID: 42517196
Free PMC article.
Single-particle analysis (SPA) by cryogenic electron microscopy (cryo-EM) has become a cornerstone of structural biology; yet, the workflow from data acquisition to a 3D structure remains a time-consuming, manual and significant task. ... …
Single-particle analysis (SPA) by cryogenic electron microscopy (cryo-EM) has become a cornerstone of str …
GoToCloud: Development and future of the cloud-based platform for cryo-EM structure-based drug DesignDevelopment and future of GoToCloud.
Prog Mol Biol Transl Sci. 2026;223:203-233. doi: 10.1016/bs.pmbts.2026.03.006. Epub 2026 Apr 3.
Prog Mol Biol Transl Sci. 2026.
PMID: 42463256
The "Resolution Revolution" in cryogenic electron microscopy (Cryo-EM) has fundamentally advanced structure-based drug design (SBDD), moving beyond static snapshots to dynamic conformational analysis. ...This design eliminates specialized IT maintenance needs …
The "Resolution Revolution" in cryogenic electron microscopy (Cryo-EM) has fundamentally advanced structure-based drug design …
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