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Low concentrations of interleukin-1 stimulate and high concentrations inhibit insulin release from isolated rat islets of Langerhans.
Spinas GA, Mandrup-Poulsen T, Mølvig J, Baek L, Bendtzen K, Dinarello CA, Nerup J. Spinas GA, et al. Acta Endocrinol (Copenh). 1986 Dec;113(4):551-8. doi: 10.1530/acta.0.1130551. Acta Endocrinol (Copenh). 1986. PMID: 3538741
Liposomal delivery of antioxidant enzymes protects against hydrogen peroxide- but not interleukin-1 beta-induced inhibition of glucose metabolism in rat pancreatic islets.
Welsh N, Margulis B, Bendtzen K, Sandler S. Welsh N, et al. J Endocrinol. 1994 Oct;143(1):151-6. doi: 10.1677/joe.0.1430151. J Endocrinol. 1994. PMID: 7964313
Expression of an insulin/interleukin-1 receptor antagonist hybrid gene in insulin-producing cell lines (HIT-T15 and NIT-1) confers resistance against interleukin-1-induced nitric oxide production.
Welsh N, Bendtzen K, Welsh M. Welsh N, et al. J Clin Invest. 1995 Apr;95(4):1717-22. doi: 10.1172/JCI117848. J Clin Invest. 1995. PMID: 7706480 Free PMC article.
Nicotinamide decreases nitric oxide production and partially protects human pancreatic islets against the suppressive effects of combinations of cytokines.
Eizirik DL, Sandler S, Welsh N, Bendtzen K, Hellerström C. Eizirik DL, et al. Autoimmunity. 1994;19(3):193-8. doi: 10.3109/08916939408995694. Autoimmunity. 1994. PMID: 7605871
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