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Benefit of Preemptive Pharmacogenetic Information on Clinical Outcome.
Roden DM, Van Driest SL, Mosley JD, Wells QS, Robinson JR, Denny JC, Peterson JF. Roden DM, et al. Clin Pharmacol Ther. 2018 May;103(5):787-794. doi: 10.1002/cpt.1035. Epub 2018 Mar 13. Clin Pharmacol Ther. 2018. PMID: 29377064 Free PMC article. Review.
The development of new knowledge around the genetic determinants of variable drug action has naturally raised the question of how this new knowledge can be used to improve the outcome of drug therapy. Two broad approaches have been taken: a point-of-care approach in …
The development of new knowledge around the genetic determinants of variable drug action has naturally raised the question of how this new k …
Preemptive pharmacogenetic testing: exploring the knowledge and perspectives of US payers.
Keeling NJ, Rosenthal MM, West-Strum D, Patel AS, Haidar CE, Hoffman JM. Keeling NJ, et al. Genet Med. 2019 May;21(5):1224-1232. doi: 10.1038/gim.2017.181. Epub 2017 Oct 26. Genet Med. 2019. PMID: 31048813 Free PMC article.
PURPOSE: Preemptive pharmacogenetic testing aims to optimize medication use by having genetic information at the point of prescribing. ...Three concept domains and ten dimensions were developed. Key findings include clinical utility concerns and limite …
PURPOSE: Preemptive pharmacogenetic testing aims to optimize medication use by having genetic information at the point …
CYP2D6 Genotype-guided Metoprolol Therapy in Cardiac Surgery Patients: Rationale and Design of the Pharmacogenetic-guided Metoprolol Management for Postoperative Atrial Fibrillation in Cardiac Surgery (PREEMPTIVE) Pilot Study.
Dunham WC, Weinger MB, Slagle J, Pretorius M, Shah AS, Absi TS, Shotwell MS, Beller M, Thomas E, Vnencak-Jones CL, Freundlich RE, Wanderer JP, Sandberg WS, Kertai MD. Dunham WC, et al. J Cardiothorac Vasc Anesth. 2020 Jan;34(1):20-28. doi: 10.1053/j.jvca.2019.09.003. Epub 2019 Sep 10. J Cardiothorac Vasc Anesth. 2020. PMID: 31606278
OBJECTIVES: The Preemptive Pharmacogenetic-guided Metoprolol Management for Atrial Fibrillation in Cardiac Surgery (PREEMPTIVE) pilot trial aims to use existing institutional resources to develop a process for integrating CYP2D6 pharmacogenetic test re …
OBJECTIVES: The Preemptive Pharmacogenetic-guided Metoprolol Management for Atrial Fibrillation in Cardiac Surgery (PREEMPT
The Integrating Pharmacogenetics in Clinical Care (I-PICC) Study: Protocol for a point-of-care randomized controlled trial of statin pharmacogenetics in primary care.
Vassy JL, Brunette CA, Majahalme N, Advani S, MacMullen L, Hau C, Zimolzak AJ, Miller SJ. Vassy JL, et al. Contemp Clin Trials. 2018 Dec;75:40-50. doi: 10.1016/j.cct.2018.10.010. Epub 2018 Oct 24. Contemp Clin Trials. 2018. PMID: 30367991 Clinical Trial.
DESIGN: The Integrating Pharmacogenetics in Clinical Care (I-PICC) Study is a pseudo-cluster randomized controlled trial of SLCO1B1 genotyping among statin-naive primary care and women's health patients across the Veteran Affairs Boston Healthca …
DESIGN: The Integrating Pharmacogenetics in Clinical Care (I-PICC) Study is a pseudo-cluster randomized controlled tria …
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