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Benefit of Preemptive Pharmacogenetic Information on Clinical Outcome.
Roden DM, Van Driest SL, Mosley JD, Wells QS, Robinson JR, Denny JC, Peterson JF. Roden DM, et al. Clin Pharmacol Ther. 2018 May;103(5):787-794. doi: 10.1002/cpt.1035. Epub 2018 Mar 13. Clin Pharmacol Ther. 2018. PMID: 29377064 Free PMC article. Review.
The development of new knowledge around the genetic determinants of variable drug action has naturally raised the question of how this new knowledge can be used to improve the outcome of drug therapy. Two broad approaches have been taken: a point-of-care approach in …
The development of new knowledge around the genetic determinants of variable drug action has naturally raised the question of how this new k …
Preemptive pharmacogenetic testing: exploring the knowledge and perspectives of US payers.
Keeling NJ, Rosenthal MM, West-Strum D, Patel AS, Haidar CE, Hoffman JM. Keeling NJ, et al. Genet Med. 2019 May;21(5):1224-1232. doi: 10.1038/gim.2017.181. Epub 2017 Oct 26. Genet Med. 2019. PMID: 31048813 Free PMC article.
PURPOSE: Preemptive pharmacogenetic testing aims to optimize medication use by having genetic information at the point of prescribing. ...Three concept domains and ten dimensions were developed. Key findings include clinical utility concerns and limite …
PURPOSE: Preemptive pharmacogenetic testing aims to optimize medication use by having genetic information at the point …
Assessment of the Implementation of Pharmacogenomic Testing in a Pediatric Tertiary Care Setting.
Cohn I, Manshaei R, Liston E, Okello JBA, Khan R, Curtis MR, Krupski AJ, Jobling RK, Kalbfleisch K, Paton TA, Reuter MS, Hayeems RZ, Verstegen RHJ, Goldman A, Kim RH, Ito S. Cohn I, et al. JAMA Netw Open. 2021 May 3;4(5):e2110446. doi: 10.1001/jamanetworkopen.2021.10446. JAMA Netw Open. 2021. PMID: 34037732 Free PMC article.
OBJECTIVES: To assess the implementation outcomes of a PGx testing program comprising both a point-of-care model that examined targeted drugs and a preemptive model informed by whole-genome sequencing that evaluated a broad range of drugs for potential …
OBJECTIVES: To assess the implementation outcomes of a PGx testing program comprising both a point-of-care model that examined …
A Cost-Consequence Analysis of Preemptive SLCO1B1 Testing for Statin Myopathy Risk Compared to Usual Care.
Brunette CA, Dong OM, Vassy JL, Danowski ME, Alexander N, Antwi AA, Christensen KD. Brunette CA, et al. J Pers Med. 2021 Oct 31;11(11):1123. doi: 10.3390/jpm11111123. J Pers Med. 2021. PMID: 34834475 Free PMC article.
We conducted a cost-consequence analysis of preemptive SLCO1B1 testing (PGx+) versus usual care (PGx-) among Veteran patients enrolled in the Integrating Pharmacogenetics in Clinical Care (I-PICC) Study. ...Despite these effects, SLCO1B1 testing …
We conducted a cost-consequence analysis of preemptive SLCO1B1 testing (PGx+) versus usual care (PGx-) among Veteran patients …
CYP2D6 Genotype-guided Metoprolol Therapy in Cardiac Surgery Patients: Rationale and Design of the Pharmacogenetic-guided Metoprolol Management for Postoperative Atrial Fibrillation in Cardiac Surgery (PREEMPTIVE) Pilot Study.
Dunham WC, Weinger MB, Slagle J, Pretorius M, Shah AS, Absi TS, Shotwell MS, Beller M, Thomas E, Vnencak-Jones CL, Freundlich RE, Wanderer JP, Sandberg WS, Kertai MD. Dunham WC, et al. J Cardiothorac Vasc Anesth. 2020 Jan;34(1):20-28. doi: 10.1053/j.jvca.2019.09.003. Epub 2019 Sep 10. J Cardiothorac Vasc Anesth. 2020. PMID: 31606278 Free PMC article.
OBJECTIVES: The Preemptive Pharmacogenetic-guided Metoprolol Management for Atrial Fibrillation in Cardiac Surgery (PREEMPTIVE) pilot trial aims to use existing institutional resources to develop a process for integrating CYP2D6 pharmacogenetic test re …
OBJECTIVES: The Preemptive Pharmacogenetic-guided Metoprolol Management for Atrial Fibrillation in Cardiac Surgery (PREEMPT
The Integrating Pharmacogenetics in Clinical Care (I-PICC) Study: Protocol for a point-of-care randomized controlled trial of statin pharmacogenetics in primary care.
Vassy JL, Brunette CA, Majahalme N, Advani S, MacMullen L, Hau C, Zimolzak AJ, Miller SJ. Vassy JL, et al. Contemp Clin Trials. 2018 Dec;75:40-50. doi: 10.1016/j.cct.2018.10.010. Epub 2018 Oct 24. Contemp Clin Trials. 2018. PMID: 30367991 Free PMC article. Clinical Trial.
DESIGN: The Integrating Pharmacogenetics in Clinical Care (I-PICC) Study is a pseudo-cluster randomized controlled trial of SLCO1B1 genotyping among statin-naive primary care and women's health patients across the Veteran Affairs Boston Healthca …
DESIGN: The Integrating Pharmacogenetics in Clinical Care (I-PICC) Study is a pseudo-cluster randomized controlled tria …