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Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava).
Unger M, Holzgrabe U, Jacobsen W, Cummins C, Benet LZ. Unger M, et al. Among authors: benet lz. Planta Med. 2002 Dec;68(12):1055-8. doi: 10.1055/s-2002-36360. Planta Med. 2002. PMID: 12494328
Antiprogestin-mediated inactivation of cytochrome P450 3A4.
Jang GR, Benet LZ. Jang GR, et al. Among authors: benet lz. Pharmacology. 1998 Mar;56(3):150-7. doi: 10.1159/000028193. Pharmacology. 1998. PMID: 9532615
Moringa oleifera leaf extracts inhibit 6beta-hydroxylation of testosterone by CYP3A4.
Monera TG, Wolfe AR, Maponga CC, Benet LZ, Guglielmo J. Monera TG, et al. Among authors: benet lz. J Infect Dev Ctries. 2008 Oct 1;2(5):379-83. doi: 10.3855/jidc.201. J Infect Dev Ctries. 2008. PMID: 19745507 Free PMC article.
Overlapping substrate specificities of cytochrome P450 3A and P-glycoprotein for a novel cysteine protease inhibitor.
Zhang Y, Guo X, Lin ET, Benet LZ. Zhang Y, et al. Among authors: benet lz. Drug Metab Dispos. 1998 Apr;26(4):360-6. Drug Metab Dispos. 1998. PMID: 9531525
Metabolism of sirolimus and its derivative everolimus by cytochrome P450 3A4: insights from docking, molecular dynamics, and quantum chemical calculations.
Kuhn B, Jacobsen W, Christians U, Benet LZ, Kollman PA. Kuhn B, et al. Among authors: benet lz. J Med Chem. 2001 Jun 7;44(12):2027-34. doi: 10.1021/jm010079y. J Med Chem. 2001. PMID: 11384247
Preliminary evaluation of progestins as inducers of cytochrome P450 3A4 activity in postmenopausal women.
Tsunoda SM, Harris RZ, Mroczkowski PJ, Benet LZ. Tsunoda SM, et al. Among authors: benet lz. J Clin Pharmacol. 1998 Dec;38(12):1137-43. J Clin Pharmacol. 1998. PMID: 11301566 Clinical Trial.
In vitro biotransformation of a novel antimalarial cysteine protease inhibitor in human liver microsomes.
Zhang Y, Guo X, Lin ET, Benet LZ. Zhang Y, et al. Among authors: benet lz. Pharmacology. 1999 Mar;58(3):147-59. doi: 10.1159/000028277. Pharmacology. 1999. PMID: 9925971
Nitroglycerin dinitrate metabolites do not affect the pharmacokinetics and pharmacodynamics of nitroglycerin in the dog: a preliminary report.
Lee FW, Hu J, Metzler CH, Benet LZ. Lee FW, et al. Among authors: benet lz. J Pharmacokinet Biopharm. 1993 Apr;21(2):163-73. doi: 10.1007/BF01059768. J Pharmacokinet Biopharm. 1993. PMID: 8229678
Lactonization is the critical first step in the disposition of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin.
Jacobsen W, Kuhn B, Soldner A, Kirchner G, Sewing KF, Kollman PA, Benet LZ, Christians U. Jacobsen W, et al. Among authors: benet lz. Drug Metab Dispos. 2000 Nov;28(11):1369-78. Drug Metab Dispos. 2000. PMID: 11038166
The Universally Unrecognized Assumption in Predicting Drug Clearance and Organ Extraction Ratio.
Benet LZ, Liu S, Wolfe AR. Benet LZ, et al. Clin Pharmacol Ther. 2018 Mar;103(3):521-525. doi: 10.1002/cpt.802. Epub 2017 Sep 6. Clin Pharmacol Ther. 2018. PMID: 28762489 Free PMC article.
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