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1,400 results
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Rapamycin passes the torch: a new generation of mTOR inhibitors.
Benjamin D, Colombi M, Moroni C, Hall MN. Benjamin D, et al. Nat Rev Drug Discov. 2011 Oct 31;10(11):868-80. doi: 10.1038/nrd3531. Nat Rev Drug Discov. 2011. PMID: 22037041 Review.
mTORC1 Controls Synthesis of Its Activator GTP.
Benjamin D, Hall MN. Benjamin D, et al. Cell Rep. 2017 Jun 27;19(13):2643-2644. doi: 10.1016/j.celrep.2017.06.032. Cell Rep. 2017. PMID: 28658613 Review.
mTORC1: turning off is just as important as turning on.
Benjamin D, Hall MN. Benjamin D, et al. Cell. 2014 Feb 13;156(4):627-8. doi: 10.1016/j.cell.2014.01.057. Cell. 2014. PMID: 24529368
TSC on the peroxisome controls mTORC1.
Benjamin D, Hall MN. Benjamin D, et al. Nat Cell Biol. 2013 Oct;15(10):1135-6. doi: 10.1038/ncb2849. Nat Cell Biol. 2013. PMID: 24084861
Syrosingopine sensitizes cancer cells to killing by metformin.
Benjamin D, Colombi M, Hindupur SK, Betz C, Lane HA, El-Shemerly MY, Lu M, Quagliata L, Terracciano L, Moes S, Sharpe T, Wodnar-Filipowicz A, Moroni C, Hall MN. Benjamin D, et al. Sci Adv. 2016 Dec 23;2(12):e1601756. doi: 10.1126/sciadv.1601756. eCollection 2016 Dec. Sci Adv. 2016. PMID: 28028542 Free PMC article.
Genome-wide shRNA screen reveals increased mitochondrial dependence upon mTORC2 addiction.
Colombi M, Molle KD, Benjamin D, Rattenbacher-Kiser K, Schaefer C, Betz C, Thiemeyer A, Regenass U, Hall MN, Moroni C. Colombi M, et al. Among authors: benjamin d. Oncogene. 2011 Mar 31;30(13):1551-65. doi: 10.1038/onc.2010.539. Epub 2010 Dec 20. Oncogene. 2011. PMID: 21170086
Lactate jump-starts mTORC1 in cancer cells.
Benjamin D, Hall MN. Benjamin D, et al. EMBO Rep. 2019 Jun;20(6):e48302. doi: 10.15252/embr.201948302. Epub 2019 May 27. EMBO Rep. 2019. PMID: 31133599 Free PMC article.
Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells.
Benjamin D, Robay D, Hindupur SK, Pohlmann J, Colombi M, El-Shemerly MY, Maira SM, Moroni C, Lane HA, Hall MN. Benjamin D, et al. Cell Rep. 2018 Dec 11;25(11):3047-3058.e4. doi: 10.1016/j.celrep.2018.11.043. Cell Rep. 2018. PMID: 30540938 Free PMC article.
BRF1 protein turnover and mRNA decay activity are regulated by protein kinase B at the same phosphorylation sites.
Benjamin D, Schmidlin M, Min L, Gross B, Moroni C. Benjamin D, et al. Mol Cell Biol. 2006 Dec;26(24):9497-507. doi: 10.1128/MCB.01099-06. Epub 2006 Oct 9. Mol Cell Biol. 2006. PMID: 17030608 Free PMC article.
mRNA stability and cancer: an emerging link?
Benjamin D, Moroni C. Benjamin D, et al. Expert Opin Biol Ther. 2007 Oct;7(10):1515-29. doi: 10.1517/14712598.7.10.1515. Expert Opin Biol Ther. 2007. PMID: 17916044 Review.
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