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EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation.
Richter GH, Plehm S, Fasan A, Rössler S, Unland R, Bennani-Baiti IM, Hotfilder M, Löwel D, von Luettichau I, Mossbrugger I, Quintanilla-Martinez L, Kovar H, Staege MS, Müller-Tidow C, Burdach S. Richter GH, et al. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5324-9. doi: 10.1073/pnas.0810759106. Epub 2009 Mar 16. Proc Natl Acad Sci U S A. 2009. PMID: 19289832 Free PMC article.
EWS-FLI1 suppresses NOTCH-activated p53 in Ewing's sarcoma.
Ban J, Bennani-Baiti IM, Kauer M, Schaefer KL, Poremba C, Jug G, Schwentner R, Smrzka O, Muehlbacher K, Aryee DN, Kovar H. Ban J, et al. Cancer Res. 2008 Sep 1;68(17):7100-9. doi: 10.1158/0008-5472.CAN-07-6145. Cancer Res. 2008. PMID: 18757425 Free PMC article.
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