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Page 1
TLX: An elusive receptor.
Benod C, Villagomez R, Webb P. Benod C, et al. J Steroid Biochem Mol Biol. 2016 Mar;157:41-7. doi: 10.1016/j.jsbmb.2015.11.001. Epub 2015 Nov 10. J Steroid Biochem Mol Biol. 2016. PMID: 26554934 Review.
A screening cascade to identify ERβ ligands.
Filgueira CS, Benod C, Lou X, Gunamalai PS, Villagomez RA, Strom A, Gustafsson JÅ, Berkenstam AL, Webb P. Filgueira CS, et al. Among authors: Benod C. Nucl Recept Signal. 2014 Nov 4;12:e003. doi: 10.1621/nrs.12003. eCollection 2014. Nucl Recept Signal. 2014. PMID: 25422593 Free PMC article.
The human orphan nuclear receptor tailless (TLX, NR2E1) is druggable.
Benod C, Villagomez R, Filgueira CS, Hwang PK, Leonard PG, Poncet-Montange G, Rajagopalan S, Fletterick RJ, Gustafsson JÅ, Webb P. Benod C, et al. PLoS One. 2014 Jun 17;9(6):e99440. doi: 10.1371/journal.pone.0099440. eCollection 2014. PLoS One. 2014. PMID: 24936658 Free PMC article.
Structure-based discovery of antagonists of nuclear receptor LRH-1.
Benod C, Carlsson J, Uthayaruban R, Hwang P, Irwin JJ, Doak AK, Shoichet BK, Sablin EP, Fletterick RJ. Benod C, et al. J Biol Chem. 2013 Jul 5;288(27):19830-44. doi: 10.1074/jbc.M112.411686. Epub 2013 May 10. J Biol Chem. 2013. PMID: 23667258 Free PMC article.
Discovery of a highly active ligand of human pregnane x receptor: a case study from pharmacophore modeling and virtual screening to "in vivo" biological activity.
Lemaire G, Benod C, Nahoum V, Pillon A, Boussioux AM, Guichou JF, Subra G, Pascussi JM, Bourguet W, Chavanieu A, Balaguer P. Lemaire G, et al. Among authors: Benod C. Mol Pharmacol. 2007 Sep;72(3):572-81. doi: 10.1124/mol.106.033415. Epub 2007 Jun 15. Mol Pharmacol. 2007. PMID: 17573484
N-1H-benzimidazol-5-ylbenzenesulfonamide derivatives as potent hPXR agonists.
Benod C, Subra G, Nahoum V, Mallavialle A, Guichou JF, Milhau J, Roblés S, Bourguet W, Pascussi JM, Balaguer P, Chavanieu A. Benod C, et al. Bioorg Med Chem. 2008 Apr 1;16(7):3537-49. doi: 10.1016/j.bmc.2008.02.020. Epub 2008 Feb 13. Bioorg Med Chem. 2008. PMID: 18304819