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Discovery of a potent and dissociated non-steroidal glucocorticoid receptor agonist containing an alkyl carbinol pharmacophore.
Razavi H, Riether D, Harcken C, Bentzien J, Dinallo RM, Souza D, Nelson RM, Kukulka A, Fadra-Khan TN, Pack EJ Jr, Zuvela-Jelaska L, Pelletier J, Panzenbeck M, Torcellini CA, Proudfoot JR, Nabozny GH, Thomson DS. Razavi H, et al. Among authors: Bentzien J. Bioorg Med Chem Lett. 2014 Apr 15;24(8):1934-40. doi: 10.1016/j.bmcl.2014.03.005. Epub 2014 Mar 12. Bioorg Med Chem Lett. 2014. PMID: 24656565
Crowdsourcing in pharma: a strategic framework.
Bentzien J, Bharadwaj R, Thompson DC. Bentzien J, et al. Drug Discov Today. 2015 Jul;20(7):874-83. doi: 10.1016/j.drudis.2015.01.011. Epub 2015 Jan 27. Drug Discov Today. 2015. PMID: 25637169 Review.
In silico predictions of genotoxicity for aromatic amines.
Bentzien J, Muegge I. Bentzien J, et al. Front Biosci (Landmark Ed). 2014 Jan 1;19:649-61. doi: 10.2741/4233. Front Biosci (Landmark Ed). 2014. PMID: 24389210
Identification of highly efficacious glucocorticoid receptor agonists with a potential for reduced clinical bone side effects.
Harcken C, Riether D, Kuzmich D, Liu P, Betageri R, Ralph M, Emmanuel M, Reeves JT, Berry A, Souza D, Nelson RM, Kukulka A, Fadra TN, Zuvela-Jelaska L, Dinallo R, Bentzien J, Nabozny GH, Thomson DS. Harcken C, et al. Among authors: Bentzien J. J Med Chem. 2014 Feb 27;57(4):1583-98. doi: 10.1021/jm4019178. Epub 2014 Feb 7. J Med Chem. 2014. PMID: 24506830
Identification of a potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor with a suitable profile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat.
Huber JD, Bentzien J, Boyer SJ, Burke J, De Lombaert S, Eickmeier C, Guo X, Haist JV, Hickey ER, Kaplita P, Karmazyn M, Kemper R, Kennedy CA, Kirrane T, Madwed JB, Mainolfi E, Nagaraja N, Soleymanzadeh F, Swinamer A, Eldrup AB. Huber JD, et al. Among authors: Bentzien J. J Med Chem. 2012 Aug 23;55(16):7114-40. doi: 10.1021/jm300601d. Epub 2012 Aug 6. J Med Chem. 2012. PMID: 22803959
Function-regulating pharmacophores in a sulfonamide class of glucocorticoid receptor agonists.
Kuzmich D, Bentzien J, Betageri R, DiSalvo D, Fadra-Khan T, Harcken C, Kukulka A, Nabozny G, Nelson R, Pack E, Souza D, Thomson D. Kuzmich D, et al. Among authors: Bentzien J. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6640-4. doi: 10.1016/j.bmcl.2013.10.052. Epub 2013 Oct 31. Bioorg Med Chem Lett. 2013. PMID: 24215891
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