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OTX015 (MK-8628), a novel BET inhibitor, displays in vitro and in vivo antitumor effects alone and in combination with conventional therapies in glioblastoma models.
Berenguer-Daizé C, Astorgues-Xerri L, Odore E, Cayol M, Cvitkovic E, Noel K, Bekradda M, MacKenzie S, Rezai K, Lokiec F, Riveiro ME, Ouafik L. Berenguer-Daizé C, et al. Int J Cancer. 2016 Nov 1;139(9):2047-55. doi: 10.1002/ijc.30256. Epub 2016 Jul 30. Int J Cancer. 2016. PMID: 27388964 Free article.
Functional Analysis of the Adrenomedullin Pathway in Malignant Pleural Mesothelioma.
Greillier L, Tounsi A, Berenguer-Daizé C, Dussault N, Delfino C, Benyahia Z, Cayol M, Mabrouk K, Garcia S, Martin PM, Barlesi F, Ouafik L. Greillier L, et al. Among authors: berenguer daize c. J Thorac Oncol. 2016 Jan;11(1):94-107. doi: 10.1016/j.jtho.2015.09.004. J Thorac Oncol. 2016. PMID: 26762744
Adrenomedullin blockade suppresses growth of human hormone-independent prostate tumor xenograft in mice.
Berenguer-Daizé C, Boudouresque F, Bastide C, Tounsi A, Benyahia Z, Acunzo J, Dussault N, Delfino C, Baeza N, Daniel L, Cayol M, Rossi D, El Battari A, Bertin D, Mabrouk K, Martin PM, Ouafik L. Berenguer-Daizé C, et al. Clin Cancer Res. 2013 Nov 15;19(22):6138-50. doi: 10.1158/1078-0432.CCR-13-0691. Epub 2013 Oct 7. Clin Cancer Res. 2013. PMID: 24100627 Free article.
Adrenomedullin blockade induces regression of tumor neovessels through interference with vascular endothelial-cadherin signalling.
Khalfaoui-Bendriss G, Dussault N, Fernandez-Sauze S, Berenguer-Daizé C, Sigaud R, Delfino C, Cayol M, Metellus P, Chinot O, Mabrouk K, Martin PM, Ouafik L. Khalfaoui-Bendriss G, et al. Among authors: berenguer daize c. Oncotarget. 2015 Apr 10;6(10):7536-53. doi: 10.18632/oncotarget.3167. Oncotarget. 2015. PMID: 25924235 Free PMC article.
Adrenomedullin promotes cell cycle transit and up-regulates cyclin D1 protein level in human glioblastoma cells through the activation of c-Jun/JNK/AP-1 signal transduction pathway.
Ouafik L, Berenguer-Daize C, Berthois Y. Ouafik L, et al. Among authors: berenguer daize c. Cell Signal. 2009 Apr;21(4):597-608. doi: 10.1016/j.cellsig.2009.01.001. Epub 2009 Jan 7. Cell Signal. 2009. PMID: 19166930
Stromal fibroblasts present in breast carcinomas promote tumor growth and angiogenesis through adrenomedullin secretion.
Benyahia Z, Dussault N, Cayol M, Sigaud R, Berenguer-Daizé C, Delfino C, Tounsi A, Garcia S, Martin PM, Mabrouk K, Ouafik L. Benyahia Z, et al. Among authors: berenguer daize c. Oncotarget. 2017 Feb 28;8(9):15744-15762. doi: 10.18632/oncotarget.14999. Oncotarget. 2017. PMID: 28178651 Free PMC article.
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