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mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1.
Jia JJ, Lahr RM, Solgaard MT, Moraes BJ, Pointet R, Yang AD, Celucci G, Graber TE, Hoang HD, Niklaus MR, Pena IA, Hollensen AK, Smith EM, Chaker-Margot M, Anton L, Dajadian C, Livingstone M, Hearnden J, Wang XD, Yu Y, Maier T, Damgaard CK, Berman AJ, Alain T, Fonseca BD. Jia JJ, et al. Among authors: berman aj. Nucleic Acids Res. 2021 Apr 6;49(6):3461-3489. doi: 10.1093/nar/gkaa1239. Nucleic Acids Res. 2021. PMID: 33398329 Free PMC article.
Testis formation in XX individuals resulting from novel pathogenic variants in Wilms' tumor 1 (WT1) gene.
Eozenou C, Gonen N, Touzon MS, Jorgensen A, Yatsenko SA, Fusee L, Kamel AK, Gellen B, Guercio G, Singh P, Witchel S, Berman AJ, Mainpal R, Totonchi M, Mohseni Meybodi A, Askari M, Merel-Chali T, Bignon-Topalovic J, Migale R, Costanzo M, Marino R, Ramirez P, Perez Garrido N, Berensztein E, Mekkawy MK, Schimenti JC, Bertalan R, Mazen I, McElreavey K, Belgorosky A, Lovell-Badge R, Rajkovic A, Bashamboo A. Eozenou C, et al. Among authors: berman aj. Proc Natl Acad Sci U S A. 2020 Jun 16;117(24):13680-13688. doi: 10.1073/pnas.1921676117. Epub 2020 Jun 3. Proc Natl Acad Sci U S A. 2020. PMID: 32493750 Free PMC article.
Controversies around the function of LARP1.
Berman AJ, Thoreen CC, Dedeic Z, Chettle J, Roux PP, Blagden SP. Berman AJ, et al. RNA Biol. 2021 Feb;18(2):207-217. doi: 10.1080/15476286.2020.1733787. Epub 2020 Apr 1. RNA Biol. 2021. PMID: 32233986 Free PMC article.
Capturing the Mechanism Underlying TOP mRNA Binding to LARP1.
Cassidy KC, Lahr RM, Kaminsky JC, Mack S, Fonseca BD, Das SR, Berman AJ, Durrant JD. Cassidy KC, et al. Among authors: berman aj. Structure. 2019 Dec 3;27(12):1771-1781.e5. doi: 10.1016/j.str.2019.10.006. Epub 2019 Oct 31. Structure. 2019. PMID: 31676287 Free PMC article.
The LARP1 La-Module recognizes both ends of TOP mRNAs.
Al-Ashtal HA, Rubottom CM, Leeper TC, Berman AJ. Al-Ashtal HA, et al. Among authors: berman aj. RNA Biol. 2021 Feb;18(2):248-258. doi: 10.1080/15476286.2019.1669404. Epub 2019 Oct 10. RNA Biol. 2021. PMID: 31601159 Free PMC article.
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