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Intraoperative transfusion of 1 U to 2 U packed red blood cells is associated with increased 30-day mortality, surgical-site infection, pneumonia, and sepsis in general surgery patients.
Bernard AC, Davenport DL, Chang PK, Vaughan TB, Zwischenberger JB. Bernard AC, et al. J Am Coll Surg. 2009 May;208(5):931-7, 937.e1-2; discussion 938-9. doi: 10.1016/j.jamcollsurg.2008.11.019. Epub 2009 Mar 26. J Am Coll Surg. 2009. PMID: 19476865
Epiploic appendagitis: an emerging diagnosis for general surgeons.
Boulanger BR, Barnes S, Bernard AC. Boulanger BR, et al. Among authors: bernard ac. Am Surg. 2002 Nov;68(11):1022-5. Am Surg. 2002. PMID: 12455800
The open peritoneal cavity: etiology correlates with the likelihood of fascial closure.
Tsuei BJ, Skinner JC, Bernard AC, Kearney PA, Boulanger BR. Tsuei BJ, et al. Among authors: bernard ac. Am Surg. 2004 Jul;70(7):652-6. Am Surg. 2004. PMID: 15279193
Supplemental enteral arginine is metabolized to ornithine in injured patients.
Tsuei BJ, Bernard AC, Barksdale AR, Rockich AK, Meier CF, Kearney PA. Tsuei BJ, et al. Among authors: bernard ac. J Surg Res. 2005 Jan;123(1):17-24. doi: 10.1016/j.jss.2004.07.006. J Surg Res. 2005. PMID: 15652946
Changing the paradigm for transfusing the anemic patient in an acute care environment.
Bernard AC, Winstead PS, Mentzer RM. Bernard AC, et al. J Ky Med Assoc. 2005 Mar;103(3):86-91. J Ky Med Assoc. 2005. PMID: 15816653 Review.
Packed red blood cell-associated arginine depletion is mediated by arginase.
Bernard A, Meier C, Lopez N, May J, Chang P, Boulanger B, Kearney P. Bernard A, et al. J Trauma. 2007 Nov;63(5):1108-12; discussion 1112. doi: 10.1097/TA.0b013e31814b2b17. J Trauma. 2007. PMID: 17993958
Red blood cell arginase suppresses Jurkat (T cell) proliferation by depleting arginine.
Bernard A, Kasten M, Meier C, Manning E, Freeman S, Adams W, Chang P, Boulanger B, Kearney P. Bernard A, et al. Surgery. 2008 Feb;143(2):286-91. doi: 10.1016/j.surg.2007.07.037. Epub 2007 Dec 21. Surgery. 2008. PMID: 18242346
Human polymerized hemoglobin for the treatment of hemorrhagic shock when blood is unavailable: the USA multicenter trial.
Moore EE, Moore FA, Fabian TC, Bernard AC, Fulda GJ, Hoyt DB, Duane TM, Weireter LJ Jr, Gomez GA, Cipolle MD, Rodman GH Jr, Malangoni MA, Hides GA, Omert LA, Gould SA; PolyHeme Study Group. Moore EE, et al. Among authors: bernard ac. J Am Coll Surg. 2009 Jan;208(1):1-13. doi: 10.1016/j.jamcollsurg.2008.09.023. Epub 2008 Nov 7. J Am Coll Surg. 2009. PMID: 19228496 Clinical Trial.
General surgical operative duration is associated with increased risk-adjusted infectious complication rates and length of hospital stay.
Procter LD, Davenport DL, Bernard AC, Zwischenberger JB. Procter LD, et al. Among authors: bernard ac. J Am Coll Surg. 2010 Jan;210(1):60-5.e1-2. doi: 10.1016/j.jamcollsurg.2009.09.034. Epub 2009 Nov 18. J Am Coll Surg. 2010. PMID: 20123333
Strangulated appendix after transabdominal preperitoneal (TAPP) inguinal hernia repair.
Procter LD, Bernard A, Kearney P. Procter LD, et al. Surg Laparosc Endosc Percutan Tech. 2010 Feb;20(1):e42-3. doi: 10.1097/SLE.0b013e3181cd66d3. Surg Laparosc Endosc Percutan Tech. 2010. PMID: 20173610
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