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Leoligin, the major lignan from Edelweiss, inhibits intimal hyperplasia of venous bypass grafts.
Reisinger U, Schwaiger S, Zeller I, Messner B, Stigler R, Wiedemann D, Mayr T, Seger C, Schachner T, Dirsch VM, Vollmar AM, Bonatti JO, Stuppner H, Laufer G, Bernhard D. Reisinger U, et al. Among authors: bernhard d. Cardiovasc Res. 2009 Jun 1;82(3):542-9. doi: 10.1093/cvr/cvp059. Epub 2009 Feb 19. Cardiovasc Res. 2009. PMID: 19228707 Free PMC article.
Lead contributes to arterial intimal hyperplasia through nuclear factor erythroid 2-related factor-mediated endothelial interleukin 8 synthesis and subsequent invasion of smooth muscle cells.
Zeller I, Knoflach M, Seubert A, Kreutmayer SB, Stelzmüller ME, Wallnoefer E, Blunder S, Frotschnig S, Messner B, Willeit J, Debbage P, Wick G, Kiechl S, Laufer G, Bernhard D. Zeller I, et al. Among authors: bernhard d. Arterioscler Thromb Vasc Biol. 2010 Sep;30(9):1733-40. doi: 10.1161/ATVBAHA.110.211011. Epub 2010 Jul 1. Arterioscler Thromb Vasc Biol. 2010. PMID: 20595649
Ursolic acid causes DNA-damage, p53-mediated, mitochondria- and caspase-dependent human endothelial cell apoptosis, and accelerates atherosclerotic plaque formation in vivo.
Messner B, Zeller I, Ploner C, Frotschnig S, Ringer T, Steinacher-Nigisch A, Ritsch A, Laufer G, Huck C, Bernhard D. Messner B, et al. Among authors: bernhard d. Atherosclerosis. 2011 Dec;219(2):402-8. doi: 10.1016/j.atherosclerosis.2011.05.025. Epub 2011 Jun 23. Atherosclerosis. 2011. PMID: 21703625
163 results