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MLL-Rearranged Leukemias-An Update on Science and Clinical Approaches.
Winters AC, Bernt KM. Winters AC, et al. Among authors: bernt km. Front Pediatr. 2017 Feb 9;5:4. doi: 10.3389/fped.2017.00004. eCollection 2017. Front Pediatr. 2017. PMID: 28232907 Free PMC article. Review.
The Functional Role of PRC2 in Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) - Mechanisms and Opportunities.
Bernt KM, Hunger SP, Neff T. Bernt KM, et al. Front Pediatr. 2016 May 18;4:49. doi: 10.3389/fped.2016.00049. eCollection 2016. Front Pediatr. 2016. PMID: 27242978 Free PMC article. Review.
Transient potential receptor melastatin-2 (Trpm2) does not influence murine MLL-AF9-driven AML leukemogenesis or in vitro response to chemotherapy.
Haladyna JN, Pastuer T, Riedel SS, Perraud AL, Bernt KM. Haladyna JN, et al. Among authors: bernt km. Exp Hematol. 2016 Jul;44(7):596-602.e3. doi: 10.1016/j.exphem.2016.03.006. Epub 2016 Mar 24. Exp Hematol. 2016. PMID: 27033163 Free PMC article.
Current concepts in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia.
Bernt KM, Hunger SP. Bernt KM, et al. Front Oncol. 2014 Mar 25;4:54. doi: 10.3389/fonc.2014.00054. eCollection 2014. Front Oncol. 2014. PMID: 24724051 Free PMC article. Review.
DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.
Chen CW, Koche RP, Sinha AU, Deshpande AJ, Zhu N, Eng R, Doench JG, Xu H, Chu SH, Qi J, Wang X, Delaney C, Bernt KM, Root DE, Hahn WC, Bradner JE, Armstrong SA. Chen CW, et al. Among authors: bernt km. Nat Med. 2015 Apr;21(4):335-43. doi: 10.1038/nm.3832. Epub 2015 Mar 30. Nat Med. 2015. PMID: 25822366 Free PMC article.
Inactivation of Eed impedes MLL-AF9-mediated leukemogenesis through Cdkn2a-dependent and Cdkn2a-independent mechanisms in a murine model.
Danis E, Yamauchi T, Echanique K, Haladyna J, Kalkur R, Riedel S, Zhu N, Xie H, Bernt KM, Orkin SH, Armstrong SA, Neff T. Danis E, et al. Among authors: bernt km. Exp Hematol. 2015 Nov;43(11):930-935.e6. doi: 10.1016/j.exphem.2015.06.005. Epub 2015 Jun 26. Exp Hematol. 2015. PMID: 26118502 Free PMC article.
Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l.
Deshpande AJ, Chen L, Fazio M, Sinha AU, Bernt KM, Banka D, Dias S, Chang J, Olhava EJ, Daigle SR, Richon VM, Pollock RM, Armstrong SA. Deshpande AJ, et al. Among authors: bernt km. Blood. 2013 Mar 28;121(13):2533-41. doi: 10.1182/blood-2012-11-465120. Epub 2013 Jan 29. Blood. 2013. PMID: 23361907 Free PMC article.
Epigenetic modifiers in normal and malignant hematopoiesis.
Haladyna JN, Yamauchi T, Neff T, Bernt KM. Haladyna JN, et al. Among authors: bernt km. Epigenomics. 2015;7(2):301-20. doi: 10.2217/epi.14.88. Epigenomics. 2015. PMID: 25942537 Review.
Targeting epigenetic programs in MLL-rearranged leukemias.
Bernt KM, Armstrong SA. Bernt KM, et al. Hematology Am Soc Hematol Educ Program. 2011;2011:354-60. doi: 10.1182/asheducation-2011.1.354. Hematology Am Soc Hematol Educ Program. 2011. PMID: 22160057 Review.
Mechanisms of Pinometostat (EPZ-5676) Treatment-Emergent Resistance in MLL-Rearranged Leukemia.
Campbell CT, Haladyna JN, Drubin DA, Thomson TM, Maria MJ, Yamauchi T, Waters NJ, Olhava EJ, Pollock RM, Smith JJ, Copeland RA, Blakemore SJ, Bernt KM, Daigle SR. Campbell CT, et al. Among authors: bernt km. Mol Cancer Ther. 2017 Aug;16(8):1669-1679. doi: 10.1158/1535-7163.MCT-16-0693. Epub 2017 Apr 20. Mol Cancer Ther. 2017. PMID: 28428443 Free article.
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