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The androgen receptor in LNCaP cells contains a mutation in the ligand binding domain which affects steroid binding characteristics and response to antiandrogens.
Veldscholte J, Berrevoets CA, Ris-Stalpers C, Kuiper GG, Jenster G, Trapman J, Brinkmann AO, Mulder E. Veldscholte J, et al. Among authors: berrevoets ca. J Steroid Biochem Mol Biol. 1992 Mar;41(3-8):665-9. doi: 10.1016/0960-0760(92)90401-4. J Steroid Biochem Mol Biol. 1992. PMID: 1562539 Review.
Studies on the human prostatic cancer cell line LNCaP.
Veldscholte J, Berrevoets CA, Mulder E. Veldscholte J, et al. Among authors: berrevoets ca. J Steroid Biochem Mol Biol. 1994 Jun;49(4-6):341-6. doi: 10.1016/0960-0760(94)90277-1. J Steroid Biochem Mol Biol. 1994. PMID: 8043498 Review.
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