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56 results
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Intense neutral drifts yield robust and evolvable consensus proteins.
Bershtein S, Goldin K, Tawfik DS. Bershtein S, et al. J Mol Biol. 2008 Jun 20;379(5):1029-44. doi: 10.1016/j.jmb.2008.04.024. Epub 2008 Apr 16. J Mol Biol. 2008. PMID: 18495157
Robustness-epistasis link shapes the fitness landscape of a randomly drifting protein.
Bershtein S, Segal M, Bekerman R, Tokuriki N, Tawfik DS. Bershtein S, et al. Nature. 2006 Dec 14;444(7121):929-32. doi: 10.1038/nature05385. Epub 2006 Nov 19. Nature. 2006. PMID: 17122770
Advances in laboratory evolution of enzymes.
Bershtein S, Tawfik DS. Bershtein S, et al. Curr Opin Chem Biol. 2008 Apr;12(2):151-8. doi: 10.1016/j.cbpa.2008.01.027. Epub 2008 Mar 7. Curr Opin Chem Biol. 2008. PMID: 18284924 Review.
Ohno's model revisited: measuring the frequency of potentially adaptive mutations under various mutational drifts.
Bershtein S, Tawfik DS. Bershtein S, et al. Mol Biol Evol. 2008 Nov;25(11):2311-8. doi: 10.1093/molbev/msn174. Epub 2008 Aug 6. Mol Biol Evol. 2008. PMID: 18687656
Soluble oligomerization provides a beneficial fitness effect on destabilizing mutations.
Bershtein S, Mu W, Shakhnovich EI. Bershtein S, et al. Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4857-62. doi: 10.1073/pnas.1118157109. Epub 2012 Mar 12. Proc Natl Acad Sci U S A. 2012. PMID: 22411825 Free PMC article.
Protein quality control acts on folding intermediates to shape the effects of mutations on organismal fitness.
Bershtein S, Mu W, Serohijos AW, Zhou J, Shakhnovich EI. Bershtein S, et al. Mol Cell. 2013 Jan 10;49(1):133-44. doi: 10.1016/j.molcel.2012.11.004. Epub 2012 Dec 6. Mol Cell. 2013. PMID: 23219534 Free PMC article.
Biophysical principles predict fitness landscapes of drug resistance.
Rodrigues JV, Bershtein S, Li A, Lozovsky ER, Hartl DL, Shakhnovich EI. Rodrigues JV, et al. Among authors: bershtein s. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):E1470-8. doi: 10.1073/pnas.1601441113. Epub 2016 Feb 29. Proc Natl Acad Sci U S A. 2016. PMID: 26929328 Free PMC article.
Bridging the physical scales in evolutionary biology: from protein sequence space to fitness of organisms and populations.
Bershtein S, Serohijos AW, Shakhnovich EI. Bershtein S, et al. Curr Opin Struct Biol. 2017 Feb;42:31-40. doi: 10.1016/ Epub 2016 Oct 31. Curr Opin Struct Biol. 2017. PMID: 27810574 Free PMC article. Review.
The interdimeric interface controls function and stability of Ureaplasma urealiticum methionine S-adenosyltransferase.
Kleiner D, Shmulevich F, Zarivach R, Shahar A, Sharon M, Ben-Nissan G, Bershtein S. Kleiner D, et al. Among authors: bershtein s. J Mol Biol. 2019 Dec 6;431(24):4796-4816. doi: 10.1016/j.jmb.2019.09.003. Epub 2019 Sep 12. J Mol Biol. 2019. PMID: 31520601
Delayed commitment to evolutionary fate in antibiotic resistance fitness landscapes.
Palmer AC, Toprak E, Baym M, Kim S, Veres A, Bershtein S, Kishony R. Palmer AC, et al. Among authors: bershtein s. Nat Commun. 2015 Jun 10;6:7385. doi: 10.1038/ncomms8385. Nat Commun. 2015. PMID: 26060115 Free PMC article.
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