Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

My NCBI Filters
Text availability
Article attribute
Article type
Publication date

Search Results

83 results
Filters applied: . Clear all Results are displayed in a computed author sort order. Results by year timeline is unavailable
Page 1
HGF/scatter factor selectively promotes cell invasion by increasing integrin avidity.
Trusolino L, Cavassa S, Angelini P, Andó M, Bertotti A, Comoglio PM, Boccaccio C. Trusolino L, et al. FASEB J. 2000 Aug;14(11):1629-40. doi: 10.1096/fj.14.11.1629. FASEB J. 2000. PMID: 10928998
Hepatocyte growth factor/scatter factor (HGF/SF) controls a genetic program known as 'invasive growth', which involves as critical steps cell adhesion, migration, and trespassing of basement membranes. ...HGF/SF, but not EGF, selectively promotes cell adhesion on laminins …
Hepatocyte growth factor/scatter factor (HGF/SF) controls a genetic program known as 'invasive growth', which involves as critical st …
A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth.
Trusolino L, Bertotti A, Comoglio PM. Trusolino L, et al. Cell. 2001 Nov 30;107(5):643-54. doi: 10.1016/s0092-8674(01)00567-0. Cell. 2001. PMID: 11733063
Surprisingly, a truncated beta4 unable to bind laminins retains the activity of wild-type alpha6beta4. Such findings invoke an unexpected role for alpha6beta4 in cancer invasion as a functional amplifier of biochemical outputs rather than a mechanical adhesiv …
Surprisingly, a truncated beta4 unable to bind laminins retains the activity of wild-type alpha6beta4. Such findings invoke an unexpe …
Tyrosine kinase signal specificity: lessons from the HGF receptor.
Bertotti A, Comoglio PM. Bertotti A, et al. Trends Biochem Sci. 2003 Oct;28(10):527-33. doi: 10.1016/j.tibs.2003.09.001. Trends Biochem Sci. 2003. PMID: 14559181
Beta4 integrin is a transforming molecule that unleashes Met tyrosine kinase tumorigenesis.
Bertotti A, Comoglio PM, Trusolino L. Bertotti A, et al. Cancer Res. 2005 Dec 1;65(23):10674-9. doi: 10.1158/0008-5472.CAN-05-2827. Cancer Res. 2005. PMID: 16322210
A beta4 nonadhesive variant still cooperates with Met for cellular transformation, confirming the adhesion-independent function of beta4 in magnification of Met biological effects. ...Our findings define beta4 as a signaling accomplice (a "servo-oncogene") of
A beta4 nonadhesive variant still cooperates with Met for cellular transformation, confirming the adhesion-independent function of be
Beta4 integrin activates a Shp2-Src signaling pathway that sustains HGF-induced anchorage-independent growth.
Bertotti A, Comoglio PM, Trusolino L. Bertotti A, et al. J Cell Biol. 2006 Dec 18;175(6):993-1003. doi: 10.1083/jcb.200605114. Epub 2006 Dec 11. J Cell Biol. 2006. PMID: 17158954 Free PMC article.
Despite being a cell-matrix adhesion molecule, beta4 integrin can prompt the multiplication of neoplastic cells dislodged from their substrates (anchorage-independent growth). ...These results unravel a novel pathway whereby beta4 directs tyrosine kinase-based signa …
Despite being a cell-matrix adhesion molecule, beta4 integrin can prompt the multiplication of neoplastic cells dislodged from their …
Met-driven invasive growth involves transcriptional regulation of Arhgap12.
Gentile A, D'Alessandro L, Lazzari L, Martinoglio B, Bertotti A, Mira A, Lanzetti L, Comoglio PM, Medico E. Gentile A, et al. Oncogene. 2008 Sep 18;27(42):5590-8. doi: 10.1038/onc.2008.173. Epub 2008 May 26. Oncogene. 2008. PMID: 18504429
Here, we describe a functional link between HGF and Arhgap12, a gene encoding a previously uncharacterized protein of the RhoGAP family. We identified Arhgap12 as a transcriptional target of HGF, through a novel gene trapping strategy. We found …
Here, we describe a functional link between HGF and Arhgap12, a gene encoding a previously uncharacterized protein of t …
met oncogene activation qualifies spontaneous canine osteosarcoma as a suitable pre-clinical model of human osteosarcoma.
De Maria R, Miretti S, Iussich S, Olivero M, Morello E, Bertotti A, Christensen JG, Biolatti B, Levine RA, Buracco P, Di Renzo MF. De Maria R, et al. J Pathol. 2009 Jul;218(3):399-408. doi: 10.1002/path.2549. J Pathol. 2009. PMID: 19402129
We studied spontaneous canine osteosarcoma (OSA) as a potential pre-clinical model for evaluation of Met-targeted therapies. ...These data implicate Met as a potentially important factor for canine OSA progression and indicate that it represents a viable mode …
We studied spontaneous canine osteosarcoma (OSA) as a potential pre-clinical model for evaluation of Met-targeted therapies. ...These …
Only a subset of Met-activated pathways are required to sustain oncogene addiction.
Bertotti A, Burbridge MF, Gastaldi S, Galimi F, Torti D, Medico E, Giordano S, Corso S, Rolland-Valognes G, Lockhart BP, Hickman JA, Comoglio PM, Trusolino L. Bertotti A, et al. Sci Signal. 2009 Dec 8;2(100):ra80. doi: 10.1126/scisignal.2000643. Sci Signal. 2009. PMID: 19996456 Corrected and republished.
We found that Met blockade affected a limited subset of Met downstream signals: Little or no effect was observed for several pathways downstream of Met; instead, only a restricted and pathway-specific signature of transducers and transcriptional effectors downstream …
We found that Met blockade affected a limited subset of Met downstream signals: Little or no effect was observed for several pathways …
Only a subset of Met-activated pathways are required to sustain oncogene addiction.
Bertotti A, Burbridge MF, Gastaldi S, Galimi F, Torti D, Medico E, Giordano S, Corso S, Rolland-Valognes G, Lockhart BP, Hickman JA, Comoglio PM, Trusolino L. Bertotti A, et al. Sci Signal. 2009;2(102):er11. doi: 10.1126/scisignal.2102er11. Sci Signal. 2009. PMID: 20039471
We found that Met blockade affected a limited subset of Met downstream signals: Little or no effect was observed for several pathways downstream of Met; instead, only a restricted and pathway-specific signature of transducers and transcriptional effectors downstream …
We found that Met blockade affected a limited subset of Met downstream signals: Little or no effect was observed for several pathways …
83 results
Jump to page
Feedback