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131 results

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Page 1
Pulsatile Basal Insulin Secretion Is Driven by Glycolytic Oscillations.
Fletcher PA, Marinelli I, Bertram R, Satin LS, Sherman AS. Fletcher PA, et al. Among authors: bertram r. Physiology (Bethesda). 2022 Jul 1;37(4):0. doi: 10.1152/physiol.00044.2021. Epub 2022 Apr 4. Physiology (Bethesda). 2022. PMID: 35378996 Free PMC article. Review.
We propose a possible mechanism for basal insulin oscillations based on oscillations in glycolysis, demonstrated using an established mathematical model. At high glucose, this is superseded by a calcium-dependent mechanism....
We propose a possible mechanism for basal insulin oscillations based on oscillations in glycolysis, demonstrated using an established mat
Mathematical modeling in neuroendocrinology.
Bertram R. Bertram R. Compr Physiol. 2015 Apr;5(2):911-27. doi: 10.1002/cphy.c140034. Compr Physiol. 2015. PMID: 25880518 Review.
Mathematical models are commonly used in neuroscience, both as tools for integrating data and as devices for designing new experiments that test model predictions. ...This article provides an overview of concepts that are useful for understanding mathematical models
Mathematical models are commonly used in neuroscience, both as tools for integrating data and as devices for designing new experiment
Active Licking Shapes Cortical Taste Coding.
Neese C, Bouaichi CG, Needham T, Bauer M, Bertram R, Vincis R. Neese C, et al. Among authors: bertram r. J Neurosci. 2022 Nov 16;42(46):8658-8669. doi: 10.1523/JNEUROSCI.0942-22.2022. Epub 2022 Oct 4. J Neurosci. 2022. PMID: 36195439 Free PMC article.
Oscillations in delayed positive feedback systems.
Ryzowicz CJ, Bertram R, Karamched BR. Ryzowicz CJ, et al. Among authors: bertram r. Phys Chem Chem Phys. 2024 Oct 2;26(38):24861-24869. doi: 10.1039/d4cp01867b. Phys Chem Chem Phys. 2024. PMID: 39291452
Symbiosis of Electrical and Metabolic Oscillations in Pancreatic β-Cells.
Marinelli I, Fletcher PA, Sherman AS, Satin LS, Bertram R. Marinelli I, et al. Among authors: bertram r. Front Physiol. 2021 Dec 3;12:781581. doi: 10.3389/fphys.2021.781581. eCollection 2021. Front Physiol. 2021. PMID: 34925070 Free PMC article. Review.
A key question that remains unresolved is whether the electrical oscillations are responsible for the metabolic oscillations via the effects of Ca(2+), or whether the metabolic oscillations are responsible for the electrical oscillations due to the effects of ATP on ATP-sensitive …
A key question that remains unresolved is whether the electrical oscillations are responsible for the metabolic oscillations via the effects …
Deconstructing the integrated oscillator model for pancreatic β-cells.
Bertram R, Marinelli I, Fletcher PA, Satin LS, Sherman AS. Bertram R, et al. Math Biosci. 2023 Nov;365:109085. doi: 10.1016/j.mbs.2023.109085. Epub 2023 Oct 4. Math Biosci. 2023. PMID: 37802364 Free PMC article.
Electrical bursting oscillations in the beta-cells of pancreatic islets have been a focus of investigation for more than fifty years. This has been aided by mathematical models, which are descendants of the pioneering Chay-Keizer model. This article describes the key bioph …
Electrical bursting oscillations in the beta-cells of pancreatic islets have been a focus of investigation for more than fifty years. This h …
Experience-Dependent Intrinsic Plasticity During Auditory Learning.
Ross MT, Flores D, Bertram R, Johnson F, Wu W, Hyson RL. Ross MT, et al. Among authors: bertram r. J Neurosci. 2019 Feb 13;39(7):1206-1221. doi: 10.1523/JNEUROSCI.1036-18.2018. Epub 2018 Dec 12. J Neurosci. 2019. PMID: 30541908 Free PMC article.
Ca2+ release or Ca2+ entry, that is the question: what governs Ca2+ oscillations in pancreatic β cells?
Fletcher PA, Thompson B, Liu C, Bertram R, Satin LS, Sherman AS. Fletcher PA, et al. Among authors: bertram r. Am J Physiol Endocrinol Metab. 2023 Jun 1;324(6):E477-E487. doi: 10.1152/ajpendo.00030.2023. Epub 2023 Apr 19. Am J Physiol Endocrinol Metab. 2023. PMID: 37074988 Free PMC article. Review.
Though this model, developed over more than 40 years through many cycles of experimentation and mathematical modeling, has been very successful, it has been challenged by a hypothesis that calcium-induced calcium release from the endoplasmic reticulum through ryanodine or …
Though this model, developed over more than 40 years through many cycles of experimentation and mathematical modeling, has been very …
131 results